The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo‐controlled clinical trials
Open accessAbstract
BACKGROUND: Skin dryness and an accelerated fragmentation of the collagen network in the dermis are hallmarks of skin aging. Nutrition is a key factor influencing skin health and consequently its appearance. A wide range of dietary supplements is offered to improve skin health. Collagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration. Our aim was to investigate the effect of oral supplementation with specific collagen peptides on skin hydration and the dermal collagen network in a clinical setting. METHODS: Two placebo-controlled clinical trials were run to assess the effect of a daily oral supplementation with collagen peptides on skin hydration by corneometry, on collagen density by high-resolution ultrasound and on collagen fragmentation by reflectance confocal microscopy. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo. RESULTS: Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Both effects persisted after 12 weeks. Ex vivo experiments demonstrated that collagen peptides induce collagen as well as glycosaminoglycan production, offering a mechanistic explanation for the observed clinical effects. CONCLUSION: The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging.
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Preclinical and pharmacokinetic studies indicate that triterpenoid-rich extracts exhibit dose-dependent biological activity despite inherently low bioavailability, supporting the rationale for a moderate dosing strategy.
“In addition, preclinical and pharmacokinetic studies indicate that triterpenoid-rich extracts exhibit dose-dependent biological activity despite inherently low bioavailability, supporting the rationale for a moderate dosing strategy [25,53,54,55,56,57].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [57]
The skin-explant results report a dose-dependent increase in collagen with Peptan, a collagen peptide preparation, not a triterpenoid-rich extract. The Clinical study sections describe Peptan dosing; searches for triterpenoids, pharmacokinetics, low bioavailability, and a moderate-dose rationale found no passage addressing the attributed claim. Page numbers were not available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measuredOral administration of collagen peptide (fish or porcine origin) significantly increased skin hydration and collagen density in facial skin and upregulated glycosaminoglycan production in ex vivo experiments.
“Oral administration of collagen peptide (a specific mixture of collagen peptides of fish origin or porcine origin) significantly increased skin hydration and collagen density in facial skin and upregulated glycosaminoglycan production in ex vivo experiments [123].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [123]
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- Authors
- Asserin, J., Lati, E., Shioya, T., & Prawitt, J.
- Affiliations
- COSderma Laboratory Bordeaux France
- BIO‐EC Laboratory Longjumeau France
- Unitec Foods Tokyo Japan
- Rousselot BVBA (Belgium) (BE)
- Corresponding author
- Prawitt, Janne
- Venue
- Journal of Cosmetic Dermatology
- Publisher
- Wiley
- Published
- 2015-09-12
- Volume
- 14
- Issue
- 4
- Pages
- 291-301
- ISSN
- 1473-2130 (ISSN-L)
- 1473-2165
- OpenAlex
- W1833910122
- Cited by
- 260
- References
- 38
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 40 · 2023: 35 · 2022: 31 · 2021: 34 · 2020: 26 · 2019: 13 · 2018: 16 · 2017: 12 · 2016: 1
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Cosmetic Dermatology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- collagen peptides, oral supplementation, skin hydration, dry skin, collagen fragmentation, skin aging, nutricosmetics, collagen density, glycosaminoglycans, extracellular matrix, skin barrier function, human skin explants
- MeSH terms
- Adult, Aged, Collagen, Double-Blind Method, Female, Glycosaminoglycans, Humans, Hyaluronic Acid, Middle Aged, Skin, Water Loss, Insensible, Skin Aging
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