Collagen peptides and the related synthetic peptides: A review on improving skin health
Open accessAbstract
With the emergence of social aging problem, people's demand for active ingredients for skin health protection and therapeutic efficacy increases. Bioactive peptides are the optimal substances for skin anti-aging with its great diversity of biological activities and high security, such as antioxidation, anti-aging, anti-diabetes, anti-hypertension, and antibacterial. In recent years, natural and synthetic anti-aging peptides have been extensively studied in vitro, in vivo and clinically. Anti-aging peptides, such as collagen peptides, can affect various physiological pathways of skin, and have significant skin protection effect when applied locally and eaten. These characteristics show that bioactive peptides can improve skin health by providing specific physiological functions. In this review, we summarized the research of anti-aging peptides and the finishing of anti-aging peptides on improving skin health which is mainly based on the collagen peptides and the related synthetic peptides.
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Zhao et al.'s review fails to address potential side effects or limitations of collagen and synthetic peptides.
“Furthermore, while the review highlights the potential benefits of collagen and synthetic peptides for skin health, it fails to address potential side effects or limitations of these interventions.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [52]
The review does address limitations. Section 3.2, “Synthetic peptide,” discusses poor skin permeability and instability, while the Conclusions note that some findings lack clinical trials and that mechanisms remain unclear. The cited claim is therefore contrary to the review on limitations, even if it does not provide a detailed discussion of adverse effects. (LLM, conf=0.90)
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Experimental — accuracy not yet measuredZhao et al.'s review on collagen and synthetic peptides has relatively low level of evidence because it primarily relies on previous studies and reviews with limited original research.
“However, the level of evidence presented in this review is relatively low. The authors primarily rely on previous studies and reviews to support their claims, with limited original research cited throughout the article.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [52]
The Introduction describes the article as a summary of prior in vitro, in vivo, and clinical research, and the Ethics statement says the review involved no human or animal experiments. That supports its reliance on existing research, but the paper does not rate its own level of evidence as relatively low. Its table of synthetic peptides also cites original clinical studies, so the assertion that original research is cited only sparingly is not established by our copy. (LLM, conf=0.83)
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Cited by
Sorted by citations
Cosmeceuticals in photoaging: A review.
Chan, L. K. W., Lee, K. W. A., Lee, C. H., Lam, K. W. P., Lee, K. F. V., Wu, R., Wan, J., Shivananjappa, S., Sky, W. T. H., Choi, H., et al. (2024) · Skin Research and Technology · doi:10.1111/srt.13730 · Cited by 23 · see citing works
“The article by Zhao et al. 52 provides a comprehensive review on the use of collagen peptides and synthetic peptides for improving skin health.”
BackgroundBiomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
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- Authors
- Zhao, X., Zhang, X., & Liu, D.
- Affiliations
- Bohai University (CN)
- Corresponding author
- Liu, Dengyong
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 86
- Pages
- 104680
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W3195978212
- Cited by
- 133
- References
- 81
- Citations by year
- 2026: 28 · 2025: 36 · 2024: 35 · 2023: 24 · 2022: 9 · 2021: 1
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Natural Science Foundation of Liaoning Province (2019-MS-006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Keywords
- collagen peptides, synthetic peptides, bioactive peptides, skin health, skin anti-aging, antioxidant activity, antidiabetic peptides, antibacterial peptides, topical application, dietary supplementation
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