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3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin
Open accessAbstract
Modification of the 2(S)-methylbutyryl moiety of mevinolin led to a series of side chain ester derivatives. A systematic exploration of the structure-activity relationships showed that the introduction of an additional aliphatic group on the carbon alpha to the carbonyl group increased potency. This observation led to the synthesis of compound 16, which has about 2.5 times the intrinsic inhibitory activity of mevinolin.
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Metadata
- Authors
- Hoffman, W. F., Alberts, A. W., Anderson, P. S., Chen, J. S., Smith, R. L., & Willard, A. K.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1986-05
- Volume
- 29
- Issue
- 5
- Pages
- 849-852
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2100458911
- Cited by
- 266
- References
- 0
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- green
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