The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)
Open accessAbstract
Memapsin 2 (beta-secretase) is one of two proteases that cleave the beta-amyloid precursor protein (APP) to produce the 40-42 residue amyloid-beta peptide (Abeta) in the human brain, a key event in the progression of Alzheimer's disease. On the basis of the X-ray crystal structure of our lead inhibitor (2, OM99-2 with eight residues) bound to memapsin, we have reduced the molecular weight and designed potent memapsin inhibitors. Structure-based design and preliminary structure-activity studies have been presented.
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Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876
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Selkoe, D. J., & Schenk, D. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140248 · Cited by 818
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
Xiao, W., Jiang, W., Chen, Z., Huang, Y., Mao, J., Zheng, W., Hu, Y., & Shi, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02107-5 · Cited by 449
Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases
Dunn, B. M. (2002) · Chemical Reviews · doi:10.1021/cr010167q · Cited by 372
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Ghosh, A. K., & Osswald, H. L. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60460h · Cited by 358
Self-citationDeveloping β‐secretase inhibitors for treatment of Alzheimer’s disease
Ghosh, A. K., Brindisi, M., & Tang, J. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07476.x · Cited by 272
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Metadata
- Authors
- Ghosh, A. K., Bilcer, G., Harwood, C., Kawahama, R., Shin, D., Hussain, K. A., Hong, L., Loy, J. A., Nguyen, C., Koelsch, G., Ermolieff, J., & Tang, J.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-08-01
- Volume
- 44
- Issue
- 18
- Pages
- 2865-2868
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2016584130
- Cited by
- 224
- References
- 1
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Ghosh, A. K., Bilcer, G., Harwood, C., Kawahama, R., Shin, D., Hussain, K. A., Hong, L., Loy, J. A., Nguyen, C., Koelsch, G., Ermolieff, J., & Tang, J. (2001). Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase). Journal of Medicinal Chemistry. https://doi.org/10.1021/jm0101803
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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