The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Developing β‐secretase inhibitors for treatment of Alzheimer’s disease
Open accessAbstract
J. Neurochem. (2012) 120 (Suppl. 1), 71–83. β‐Secretase (memapsin 2; BACE‐1) is the first protease in the processing of amyloid precursor protein leading to the production of amyloid‐β (Aβ) in the brain. It is believed that high levels of brain Aβ are responsible for the pathogenesis of Alzheimer’s disease (AD). Therefore, β‐secretase is a major therapeutic target for the development of inhibitor drugs. During the past decade, steady progress has been made in the evolution of β‐secretase inhibitors toward better drug properties. Recent inhibitors are potent, selective and have been shown to penetrate the blood‐brain barrier to inhibit Aβ levels in the brains of experimental animals. Moreover, continuous administration of a β‐secretase inhibitor was shown to rescue age‐related cognitive decline in transgenic AD mice. A small number of β‐secretase inhibitors have also entered early phase clinical trials. These developments offer some optimism for the clinical development of a disease‐modifying drug for AD.
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1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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RetractedBACE1 is the major β-secretase for generation of Aβ peptides by neurons
Cai, H., Wang, Y., McCarthy, D., Wen, H., Borchelt, D. R., Price, D. L., & Wong, P. C. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 1,064
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Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
Selkoe, D. J., & Schenk, D. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.140248 · Cited by 818
Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., & Tang, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1456 · Cited by 776
Self-citationThe Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease
Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., & Ashe, K. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01858.2002 · Cited by 718
Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor
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Methods and Principles in Medicinal Chemistry
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Current and future treatments for Alzheimer's disease
Yiannopoulou, K. G., & Papageorgiou, S. G. (2013) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285612461679 · Cited by 677
Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease
Barage, S. H., & Sonawane, K. D. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.06.008 · Cited by 579
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
Morris, G. P., Clark, I. A., & Vissel, B. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0135-5 · Cited by 522
The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy
McGeer, P. L., & McGeer, E. G. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1177-7 · Cited by 467
Metadata
- Authors
- Ghosh, A. K., Brindisi, M., & Tang, J.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2011-11-28
- Volume
- 120
- Issue
- s1
- Pages
- 71-83
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1816679421
- Cited by
- 272
- References
- 71
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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