The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase
Open accessAbstract
A set of 17 coumarin and 2 chromone derivatives with known inhibitory activity toward monoamine oxidase (MAO) A and B were tested as acetylcholinesterase (AChE) inhibitors. All compounds inhibited AChE with values in the micromolar range (3-100 microM). A kinetic study showed that most compounds acted as noncompetitive AChE inhibitors. This finding may be of interest in the context of Alzheimer's disease because recent observations suggest that MAO and AChE inhibition might decrease beta-amyloid deposition.
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Citations
Cites
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The cholinergic hypothesis of geriatric memory dysfunction
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Self-citationThe role of neurotrophic factors in regulating the development of inner ear innervation
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Binda, C., Wang, J., Pisani, L., Caccia, C., Carotti, A., Salvati, P., Edmondson, D. E., & Mattevi, A. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070677y · Cited by 607
Self-citationA review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease
Anand, P., Singh, B., & Singh, N. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.12.042 · Cited by 527
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Metadata
- Authors
- Brühlmann, C., Ooms, F., Carrupt, P.-A., Testa, B., Catto, M., Leonetti, F., Altomare, C., & Carotti, A.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2001-08-21
- Volume
- 44
- Issue
- 19
- Pages
- 3195-3198
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1998253336
- Cited by
- 290
- References
- 10
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
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