The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus
Abstract
In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
Coronavirus Spike Proteins in Viral Entry and Pathogenesis
Gallagher, T. M., & Buchmeier, M. J. (2001) · Virology · doi:10.1006/viro.2000.0757 · Cited by 658
Forskolin as a Tool for Examining Adenylyl Cyclase Expression, Regulation, and G Protein Signaling
Insel, P. A., & Ostrom, R. S. (2003) · Cellular and Molecular Neurobiology · doi:10.1023/a:1023684503883 · Cited by 277
Cited by
Zhang, D.-H., Wu, K.-L., Zhang, X., Deng, S.-Q., & Peng, B. (2020) · Journal of Integrative Medicine · doi:10.1016/j.joim.2020.02.005 · Cited by 482
Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease
Kandeel, M., & Al-Nazawi, M. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117627 · Cited by 412
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics
Ghosh, A. K., Brindisi, M., Shahabi, D., Chapman, M. E., & Mesecar, A. D. (2020) · ChemMedChem · doi:10.1002/cmdc.202000223 · Cited by 306
Antiinflammatory Activities of Curcumin and Spirulina: Focus on Their Role against COVID-19
Perna, A., Hay, E., Sellitto, C., Del Genio, E., De Falco, M., Guerra, G., De Luca, A., De Blasiis, P., & Lucariello, A. (2023) · Journal of Dietary Supplements · doi:10.1080/19390211.2023.2173354 · Cited by 12
Metadata
- Authors
- Wen, C.-C., Kuo, Y.-H., Jan, J.-T., Liang, P.-H., Wang, S.-Y., Liu, H.-G., Lee, C.-K., Chang, S.-T., Kuo, C.-J., Lee, S.-S., Hou, C.-C., Hsiao, P.-W., Chien, S.-C., Shyur, L.-F., & Yang, N.-S.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-07-31
- Volume
- 50
- Issue
- 17
- Pages
- 4087-4095
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2102380386
- Cited by
- 576
- References
- 3
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wen, C.-C., Kuo, Y.-H., Jan, J.-T., Liang, P.-H., Wang, S.-Y., Liu, H.-G., Lee, C.-K., Chang, S.-T., Kuo, C.-J., Lee, S.-S., Hou, C.-C., Hsiao, P.-W., Chien, S.-C., Shyur, L.-F., & Yang, N.-S. (2007). Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm070295s
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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