The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents
Open accessAbstract
Chemonociception represents an important signaling mechanism of acute pain, but it may also contribute to persistent pain, especially in the context of peripheral tissue injury and inflammation. The primary role of TRPA1 as a general and non-specific sensor of a variety of chemical species, generated by diverse enzymatic or non-enzymatic proinflammatory pathways, underlines the hypothesis that compounds that block channel activity represent a new class of analgesic medicine. The emerging role of neuronal TRPA1 in the orchestration of the inflammatory response in animal models of airway diseases, including asthma and COPD is of much interest and TRPA1 antagonists could be regarded as novel antitussive medicines.
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Citations
Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
TRPA1 regulates gastrointestinal motility through serotonin release from enterochromaffin cells
Nozawa, K., Kawabata-Shoda, E., Doihara, H., Kojima, R., Okada, H., Mochizuki, S., Sano, Y., Inamura, K., Matsushime, H., Koizumi, T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805323106 · Cited by 399
Cited by
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
Alexander, S. P. H., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 606
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
Nassini, R., Gees, M., Harrison, S., De Siena, G., Materazzi, S., Moretto, N., Failli, P., Preti, D., Marchetti, N., Cavazzini, A., et al. (2011) · Pain · doi:10.1016/j.pain.2011.02.051 · Cited by 324
Self-citationParacetamol – An old drug with new mechanisms of action
Przybyła, G. W., Szychowski, K. A., & Gmiński, J. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13392 · Cited by 190
Metadata
- Authors
- Baraldi, P. G., Preti, D., Materazzi, S., & Geppetti, P.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-04-01
- Volume
- 53
- Issue
- 14
- Pages
- 5085-5107
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1999470879
- Cited by
- 176
- References
- 2
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- green
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- Baraldi, P. G., Preti, D., Materazzi, S., & Geppetti, P. (2010). Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm100062h
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