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Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
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ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTNitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile PharmacophoreFraser F. Fleming*†, Lihua Yao†, P. C. Ravikumar†, Lee Funk‡, and Brian C. Shook§View Author Information† Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530‡ Mylan Pharmaceuticals Inc., 781 Chestnut Ridge Road, Morgantown, West Virginia 26505§ Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean Roads, P.O. Box 776, Spring House, Pennsylvania 19477*To whom correspondence should be addressed. Phone: (412) 396 6031. Fax: (412) 396 5683. E-mail: [email protected]Cite this: J. Med. Chem. 2010, 53, 22, 7902–7917Publication Date (Web):August 30, 2010Publication History Received23 June 2010Published online30 August 2010Published inissue 25 November 2010https://pubs.acs.org/doi/10.1021/jm100762rhttps://doi.org/10.1021/jm100762rreview-articleACS PublicationsCopyright © 2010 American Chemical SocietyRequest reuse permissionsArticle Views24169Altmetric-Citations1285LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inhibitors,Nitrogen compounds,Noncovalent interactions,Peptides and proteins,Pharmaceuticals Get e-Alerts
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Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00129-0 · Cited by 18,139
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An Extremely Potent Inhibitor of Xanthine Oxidoreductase
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Cited by
Ertl, P., Altmann, E., & McKenna, J. M. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00754 · Cited by 429
Covalent inhibitors design and discovery.
De Cesco, S., Kurian, J., Dufresne, C., Mittermaier, A. K., & Moitessier, N. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.06.019 · Cited by 315
Stimulated Raman scattering microscopy: an emerging tool for drug discovery
Tipping, W. J., Lee, M., Serrels, A., Brunton, V. G., & Hulme, A. N. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00693g · Cited by 266
HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design
Zhan, P., Chen, X., Li, D., Fang, Z., De Clercq, E., & Liu, X. (2013) · Medicinal Research Reviews · doi:10.1002/med.20241 · Cited by 192
Niu, G., Zheng, X., Zhao, Z., Zhang, H., Wang, J., He, X., Chen, Y., Shi, X., Ma, C., Kwok, R. T. K., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b06196 · Cited by 183
Metadata
- Authors
- Fleming, F. F., Yao, L., Ravikumar, P. C., Funk, L., & Shook, B. C.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-08-30
- Volume
- 53
- Issue
- 22
- Pages
- 7902-7917
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2045809294
- Cited by
- 1,754
- References
- 6
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- green
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