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Assessing Atropisomer Axial Chirality in Drug Discovery and Development
Abstract
ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTAssessing Atropisomer Axial Chirality in Drug Discovery and DevelopmentSteven R. LaPlante*†, Lee D. Fader†, Keith R. Fandrick‡, Daniel R. Fandrick‡, Oliver Hucke†, Ray Kemper‡, Stephen P. F. Miller§, and Paul J. Edwards*†View Author Information† Department of Chemistry, Boehringer Ingelheim (Canada) Ltd., 2100 Cunard Street, Laval, Quebec, H7S 2G5, Canada‡ Chemical Development, Non-Clinical Drug Safety, Boehringer Ingelheim Pharmaceutical Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States§ Office of New Drug Quality Assessment, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Avenue, Building 22, Room 1446, Silver Spring, Maryland 20993, United States*For S.R.L.: phone, 1-450-682-4640; fax, 1-450-682-8434; e-mail, [email protected]. For P.J.E.: phone, 1-450-682-4640; e-mail, [email protected]Cite this: J. Med. Chem. 2011, 54, 20, 7005–7022Publication Date (Web):August 17, 2011Publication History Received10 May 2011Published online15 September 2011Published inissue 27 October 2011https://pubs.acs.org/doi/10.1021/jm200584ghttps://doi.org/10.1021/jm200584greview-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views17317Altmetric-Citations577LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chirality,Drug discovery,Mixtures,Molecular structure,Pharmaceuticals Get e-Alerts
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Citations
Cites
Putting chirality to work: the strategy of chiral switches
Agranat, I., Caner, H., & Caldwell, J. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd915 · Cited by 637
Are Oral Contraceptives a Significant Contributor to the Estrogenicity of Drinking Water?
Wise, A., O’Brien, K., & Woodruff, T. (2011) · Environmental Science & Technology · doi:10.1021/es1014482 · Cited by 150
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Metadata
- Authors
- LaPlante, S. R., Fader, L. D., Fandrick, K. R., Fandrick, D. R., Hucke, O., Kemper, R., Miller, S. P. F., & Edwards, P. J.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-09-15
- Volume
- 54
- Issue
- 20
- Pages
- 7005-7022
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2335442430
- Cited by
- 861
- References
- 2
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- LaPlante, S. R., Fader, L. D., Fandrick, K. R., Fandrick, D. R., Hucke, O., Kemper, R., Miller, S. P. F., & Edwards, P. J. (2011). Assessing Atropisomer Axial Chirality in Drug Discovery and Development. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm200584g
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