The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Adenosine A 2A Receptor as a Drug Discovery Target
Open accessAbstract
The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacology, and molecular structure, followed by a summary and SAR discussion of the most relevant series of adenosine A2A agonists and antagonists. This review also provides an update of the A2A ligands that are undergoing or have undergone clinical studies, including the two currently marketed agonists adenosine and regadenoson.
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Citations
Cites
Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431
Are Methylxanthine Effects Due to Antagonism of Endogenous Adenosine?
Fredholm, B. B. (1979) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(79)90046-4 · Cited by 409
Adenosine: does it have a neuroprotective role after all?
de Mendonça, A., Sebastião, A. M., & Ribeiro, J. A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00033-3 · Cited by 248
Cited by
Pharmacology of Adenosine Receptors: The State of the Art
Borea, P. A., Gessi, S., Merighi, S., Vincenzi, F., & Varani, K. (2018) · Physiological Reviews · doi:10.1152/physrev.00049.2017 · Cited by 783
Adenosine 2A Receptor Blockade as an Immunotherapy for Treatment-Refractory Renal Cell Cancer
Fong, L., Hotson, A., Powderly, J. D., Sznol, M., Heist, R. S., Choueiri, T. K., George, S., Hughes, B. G. M., Hellmann, M. D., Shepard, D. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0980 · Cited by 352
Lu, Y., Qin, S., Zhang, B., Dai, A., Cai, X., Ma, M., Gao, Z.-G., Yang, D., Stevens, R. C., Jacobson, K. A., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00477 · Cited by 39
Lowe, P. T., Dall'Angelo, S., Mulder‐Krieger, T., IJzerman, A. P., Zanda, M., & O'Hagan, D. (2017) · ChemBioChem · doi:10.1002/cbic.201700382 · Cited by 19
Metadata
- Authors
- de Lera Ruiz, M., Lim, Y.-H., & Zheng, J.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-11-15
- Volume
- 57
- Issue
- 9
- Pages
- 3623-3650
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1979019662
- Cited by
- 276
- References
- 3
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- green
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- de Lera Ruiz, M., Lim, Y.-H., & Zheng, J. (2014). Adenosine A 2A Receptor as a Drug Discovery Target. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm4011669
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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