The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress: Miniperspective
Open accessAbstract
Protein structure underlies essential biological processes and provides a blueprint for molecular mimicry that drives drug discovery. Although small molecules represent the lion's share of agents that target proteins for therapeutic benefit, there remains no substitute for the natural properties of proteins and their peptide subunits in the majority of biological contexts. The peptide α-helix represents a common structural motif that mediates communication between signaling proteins. Because peptides can lose their shape when taken out of context, developing chemical interventions to stabilize their bioactive structure remains an active area of research. The all-hydrocarbon staple has emerged as one such solution, conferring α-helical structure, protease resistance, cellular penetrance, and biological activity upon successful incorporation of a series of design and application principles. Here, we describe our more than decade-long experience in developing stapled peptides as biomedical research tools and prototype therapeutics, highlighting lessons learned, pitfalls to avoid, and keys to success.
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Self-citationActivation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix
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Self-citationMDM4 is a key therapeutic target in cutaneous melanoma
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Self-citationStructure of the Stapled p53 Peptide Bound to Mdm2
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Cited by
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
Scott, D. E., Bayly, A. R., Abell, C., & Skidmore, J. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.29 · Cited by 1,137
Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges
Vinogradov, A. A., Yin, Y., & Suga, H. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13178 · Cited by 848
Peptide stapling techniques based on different macrocyclisation chemistries
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Orally Absorbed Cyclic Peptides
Nielsen, D. S., Shepherd, N. E., Xu, W., Lucke, A. J., Stoermer, M. J., & Fairlie, D. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00838 · Cited by 445
Systematic Targeting of Protein–Protein Interactions
Modell, A. E., Blosser, S. L., & Arora, P. S. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.008 · Cited by 184
Metadata
- Authors
- Walensky, L. D., & Bird, G. H.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-03-06
- Volume
- 57
- Issue
- 15
- Pages
- 6275-6288
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2042061022
- Cited by
- 795
- References
- 12
- FWCI
- 27.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
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