Direct inhibition of the NOTCH transcription factor complex

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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Mutations in NOTCH1 cause aortic valve disease

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Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

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Notch1 functions as a tumor suppressor in mouse skin

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Notch signals control the fate of immature progenitor cells in the intestine

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

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MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors

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Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

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γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

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Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

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Crystal Structure of the CSL-Notch-Mastermind Ternary Complex Bound to DNA

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Growth Suppression of Pre-T Acute Lymphoblastic Leukemia Cells by Inhibition of Notch Signaling

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Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

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Essential Roles for Ankyrin Repeat and Transactivation Domains in Induction of T-Cell Leukemia by Notch1

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Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines

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Notch3 Gene Amplification in Ovarian Cancer

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γ-Secretase Inhibitor Prevents Notch3 Activation and Reduces Proliferation in Human Lung Cancers

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

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Mastermind is a putative activator for Notch

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A Novel Noninvasive Model of Endometriosis for Monitoring the Efficacy of Antiangiogenic Therapy

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Therapeutic antibody targeting of individual Notch receptors

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Notch Signaling in the Immune System

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Modulators of Protein–Protein Interactions

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Notch Signaling and the Skeleton.

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RNA Display Methods for the Discovery of Bioactive Macrocycles

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Stapled Helical Peptides Bearing Different Anchoring Residues

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An orthosteric inhibitor of the Ras-Sos interaction

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Hydrocarbon Stapled Peptides as Modulators of Biological Function

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Targeting Transcription Factors in Cancer

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Targeting Notch in oncology: the path forward

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Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

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Interfacial inhibitors: targeting macromolecular complexes

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Emerging roles of TEAD transcription factors and its coactivators in cancers

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Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

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The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia

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Design and Structure of Stapled Peptides Binding to Estrogen Receptors

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Evolving the use of peptides as components of biomaterials

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In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

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Notch: The Past, the Present, and the Future

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GSEA-InContext: identifying novel and common patterns in expression experiments

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What makes a good drug target?

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Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

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D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms

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Therapeutic Strategies to Inhibit MYCPreprint

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Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints

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Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer

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Towards understanding cell penetration by stapled peptides

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Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming

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Functionalised staple linkages for modulating the cellular activity of stapled peptides

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Cell-Permeable Cyclic Peptides from Synthetic Libraries Inspired by Natural Products

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Mechanistic Insights into Notch Receptor Signaling from Structural and Biochemical Studies

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Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia

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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

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Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics

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Protein-protein interaction modulators: advances, successes and remaining challenges

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DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes

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Targeting Protein-Protein Interaction by Small Molecules

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Precision medicine for human cancers with Notch signaling dysregulation (Review)

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Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy

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Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

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A complex task? Direct modulation of transcription factors with small molecules

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A Thiol–Ene Coupling Approach to Native Peptide Stapling and Macrocyclization

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Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

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New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

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How Chemoproteomics Can Enable Drug Discovery and Development

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Structural biology and drug discovery for protein–protein interactions

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Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products

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Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

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Comparative α‐Helicity of Cyclic Pentapeptides in Water

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Notch signaling: Emerging molecular targets for cancer therapy

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Stapled Peptides Inhibitors: A New Window for Target Drug Discovery

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The N otch pathway in colorectal cancer

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Expanding the Number of ‘Druggable’ Targets: Non‐Enzymes and Protein–Protein Interactions

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The Notch signaling pathway: a potential target for cancer immunotherapy

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Molecular Pathways: Translational and Therapeutic Implications of the Notch Signaling Pathway in Cancer

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Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination

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Computational design of peptide ligands

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A Notch above other inhibitors

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Direct inhibition of the Notch transactivation complex with stapled peptides in T-ALL

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Direct Inhibition of the Notch Transactivation Complex with Synthetic Constrained Peptides in T-Cell Acute Lymphoblastic Leukemia.

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