The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Iso combretastatins A versus Combretastatins A: The Forgotten iso CA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent
Abstract
Herein is reported a convergent synthesis of isocombretastatins A, a novel class of potent antitubulin agents. These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry. The discovery of isoCA-4 with biological activities comparable to that of CA-4 represents a major progress in this field.
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Cites
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Cited by
Nepali, K., Sharma, S., Sharma, M., Bedi, P. M. S., & Dhar, K. L. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.03.018 · Cited by 435
Direct electrochemical defluorinative carboxylation of α-CF 3 alkenes with carbon dioxide
Gao, X.-T., Zhang, Z., Wang, X., Tian, J.-S., Xie, S.-L., Zhou, F., & Zhou, J. (2020) · Chemical Science · doi:10.1039/d0sc04091f · Cited by 142
Metadata
- Authors
- Messaoudi, S., Tréguier, B., Hamze, A., Provot, O., Peyrat, J.-F., De Losada, J. R., Liu, J.-M., Bignon, J., Wdzieczak-Bakala, J., Thoret, S., Dubois, J., Brion, J.-D., & Alami, M.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-06-16
- Volume
- 52
- Issue
- 14
- Pages
- 4538-4542
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W2092352405
- Cited by
- 287
- References
- 18
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Iso combretastatins A versus Combretastatins A: The Forgotten iso CA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent. https://app.cochat.ai/papers/10.1021/jm900321u
- The paper
- Messaoudi, S., Tréguier, B., Hamze, A., Provot, O., Peyrat, J.-F., De Losada, J. R., Liu, J.-M., Bignon, J., Wdzieczak-Bakala, J., Thoret, S., Dubois, J., Brion, J.-D., & Alami, M. (2009). Iso combretastatins A versus Combretastatins A: The Forgotten iso CA-4 Isomer as a Highly Promising Cytotoxic and Antitubulin Agent. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm900321u
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
