The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Depsides and Depsidones as Inhibitors of HIV-1 Integrase: Discovery of Novel Inhibitors through 3D Database Searching
Open accessAbstract
Seventeen lichen acids comprising despides, depsidones, and their synthetic derivatives have been examined for their inhibitory activity against HIV-1 integrase, and two pharmacophores associated with inhibition of this enzyme have been identified. A search of the NCI 3D database of approximately 200,000 structures yielded some 800 compounds which contain one or the other pharmacophore. Forty-two of these compounds were assayed for HIV-1 integrase inhibition, and of these, 27 had inhibitory IC50 values of less than 100 microM; 15 were below 50 microM. Several of these compounds were also examined for their activity against HIV-2 integrase and mammalian topoisomerase I.
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Citations
Cites
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
Engelman, A., Mizuuchi, K., & Craigie, R. (1991) · Cell · doi:10.1016/0092-8674(91)90297-c · Cited by 655
Inhibition of HIV Infection by Caffeoylquinic Acid Derivatives
Mahmood, N., Moore, P. S., De Tommasi, N., De Simone, F., Colman, S., Hay, A. J., & Pizza, C. (1993) · Antiviral Chemistry and Chemotherapy · doi:10.1177/095632029300400406 · Cited by 119
Cited by
Integrase inhibitors to treat HIV/Aids
Pommier, Y., Johnson, A. A., & Marchand, C. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1660 · Cited by 688
Self-citationLichens as a potential natural source of bioactive compounds: a review
Shukla, V., Joshi, G. P., & Rawat, M. S. M. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9189-6 · Cited by 277
Developing a Dynamic Pharmacophore Model for HIV-1 Integrase
Carlson, H. A., Masukawa, K. M., Rubins, K., Bushman, F. D., Jorgensen, W. L., Lins, R. D., Briggs, J. M., & McCammon, J. A. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990322h · Cited by 259
McDougall, B., King, P. J., Wu, B. W., Hostomsky, Z., Reinecke, M. G., & Robinson, W. E. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.1.140 · Cited by 210
Metadata
- Authors
- Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Nicklaus, M. C., Milne, G. W. A., Proksa, B., & Pommier, Y.
- Venue
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-03-01
- Volume
- 40
- Issue
- 6
- Pages
- 942-951
- ISSN
- 0022-2623 (ISSN-L)
- 1520-4804
- OpenAlex
- W1976872345
- Cited by
- 208
- References
- 2
- FWCI
- 18.23
- Type
- journal article
- Language
- en
- Open access
- green
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