The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection
Abstract
Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.
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Citations
Cites
Natural products as sources of new drugs over the period 1981–2002
Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082
The influence of natural products upon drug discovery (Antiquity to late 1999)
Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293
Roe, S. M., Prodromou, C., O'Brien, R., Ladbury, J. E., Piper, P. W., & Pearl, L. H. (1999) · Journal of Medicinal Chemistry · doi:10.1021/jm980403y · Cited by 1,004
Halichondrins-antitumor polyether macrolides from a marine sponge
Hirata, Y., & Uemura, D. (1986) · Pure and Applied Chemistry · doi:10.1351/pac198658050701 · Cited by 519
Cited by
Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds
Rosen, B. M., Quasdorf, K. W., Wilson, D. A., Zhang, N., Resmerita, A.-M., Garg, N. K., & Percec, V. (2011) · Chemical Reviews · doi:10.1021/cr100259t · Cited by 1,371
Impact of Natural Products on Developing New Anti-Cancer Agents
Cragg, G. M., Grothaus, P. G., & Newman, D. J. (2009) · Chemical Reviews · doi:10.1021/cr900019j · Cited by 1,302
Natural products to drugs: natural product-derived compounds in clinical trials
Butler, M. S. (2008) · Natural Product Reports · doi:10.1039/b514294f · Cited by 1,075
Natural Products as Platforms To Overcome Antibiotic Resistance
Rossiter, S. E., Fletcher, M. H., & Wuest, W. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00283 · Cited by 622
Synthesis at the molecular frontier
Wender, P. A., & Miller, B. L. (2009) · Nature · doi:10.1038/460197a · Cited by 579
Natural products: A lead for drug discovery and development
Chopra, B., & Dhingra, A. K. (2021) · Phytotherapy Research · doi:10.1002/ptr.7099 · Cited by 469
Plant natural products: Back to the future or into extinction?
McChesney, J. D., Venkataraman, S. K., & Henri, J. T. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.04.032 · Cited by 377
Rishton, G. M. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.007 · Cited by 276
Metadata
- Authors
- Wilson, R. M., & Danishefsky, S. J.
- Venue
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-08-03
- Volume
- 71
- Issue
- 22
- Pages
- 8329-8351
- ISSN
- 0022-3263 (ISSN-L)
- 1520-6904
- OpenAlex
- W2949332675
- Cited by
- 387
- References
- 4
- FWCI
- 17.35
- Type
- journal article
- Language
- en
- Open access
- closed
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