CoChat
Sign Up
Cited by 622Microbial Natural Products and BiosynthesisAntimicrobial agents and applicationsAntimicrobial Peptides and Activities

Natural Products as Platforms To Overcome Antibiotic Resistance

Open access
Rossiter, Sean E., Fletcher, Madison H., Wuest, William M.·2017·Chemical Reviews
DOI 10.1021/acs.chemrev.7b00283PMC PMC5869711
Open this paper in CoChat — free account

Abstract

Natural products have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics of the mid-20th century. However, the increasing frequency of antibiotic-resistant infections clearly demonstrates that new antibiotics are critical for modern medicine. Because combinatorial approaches have not yielded effective drugs, we propose that the development of new antibiotics around proven natural scaffolds is the best short-term solution to the rising crisis of antibiotic resistance. We analyze herein synthetic approaches aiming to reengineer natural products into potent antibiotics. Furthermore, we discuss approaches in modulating quorum sensing and biofilm formation as a nonlethal method, as well as narrow-spectrum pathogen-specific antibiotics, which are of interest given new insights into the implications of disrupting the microbiome.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1021/acs.chemrev.7b00283

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • PDT utilizing next-generation metal-based photosensitizers with extended excitation and emission spectra holds significant promise for antibacterial applications.

    “PDT utilizing next-generation metal-based photosensitizers with extended excitation and emission spectra holds significant promise for antibacterial applications16,241.”

    From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [241]

    The supplied passages and searches of the paper’s full text for photodynamic therapy, metal-based photosensitizers, and excitation and emission spectra found no passage addressing this claim. Section 6.3 discusses antibacterial phenazine and quinoline analogs, but not their use in PDT or the claimed spectral properties. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 236

  1. [1]Patridge E Gareiss P Kinch MS Hoyer D An Analysis of FDA-Approved Drugs: Natural Products and Their Derivatives Drug Discovery Today 2016 21 204 207 25617672
  2. [2]Neu H Crisis in Antibiotic Resistance Science 1992 257 1064 1073 1509257
  3. [3]Spellberg B Gilbert DN The Future of Antibiotics and Resistance: A Tribute to a Career of Leadership by John Bartlett Clin Infect Dis 2014 59 Suppl 2 71 75 25151481 PMC4176319
  4. [4]Viswanathan VK Off-Label Abuse of Antibiotics by Bacteria Gut Microbes 2014 5 3 4 24637595 PMC4049933
  5. [6]Goossens H Ferech M Coenen S Stephens P the European Sureillance of Antimicrobial Consumption Project Group Comparison of Outpatient Systemic Antibacterial Use in 2004 in the United States and 27 European Countries Clin Infect Dis 2007 44 1091 1095 17366456
  6. [7]Boeckel TPVan Gandra S Ashok A Caudron Q Grenfell BT Levin SA Laxminarayan R Global Antibiotic Consumption 2000 to 2010: An Analysis of National Pharmaceutical Sales Data Lancet Infect Dis 2014 14 742 750 25022435
  7. [8]Levy SB Marshall B Antibacterial Resistance Worldwide: Causes, Challenges and Responses Nat Med 2004 10 S122 S129 15577930
  8. [9]Barber M Rozwadowska-dowzenko M Infection by Penicillin Resistant Staphylococci Lancet 1948 252 641 644 18890505
  9. [10]Levy SB Microbial Resistance to Antibiotics: An Evolving and Persistant Problem Lancet 1982 320 83 88 6123819
  10. [12]White DG Zhao S Sudler R Ayers S Friedman S Chen S McDermott PF McDermott S Wagner DD Meng J The Isolation of Antibiotic-Resistant Salmonella from Retail Ground Meats N Engl J Med 2001 345 1147 1154 11642230
  11. [13]Chiu C-H Wu T-L Su L-H Chu C Chia J-H Kuo A-J Chien M-S Lin T-Y The Emergence in Taiwan of Fluoroquinolone Resistance in Salmonella Enterica Serotype Choleraesuis N Engl J Med 2002 346 413 419 11832529
  12. [14]O’Neill J Tackling Drug-Resistant Infections Globally: Final Report and Recommendations the Review on Antimicrobial Resistance 2016
  13. [15]McCullough AR Parekh S Rathbone J Del Mar CB Hoffmann TC A Systematic Review of the Public’s Knowledge and Beliefs about Antibiotic Resistance J Antimicrob Chemother 2016 71 27 33 26459555
  14. [16]WHO Antimicrobial Resistance Bull World Health Organ 2014 61 383 394 PMC2536104 6603914
  15. [17]Johnning A Kristiansson E Angelin M Marathe N Shouche YS Johansson A Larsson DGJ Quinolone Resistance Mutations in the Faecal Microbiota of Swedish Travellers to India BMC Microbiol 2015 15 235 242 26498929 PMC4619388
  16. [18]Walsh C Antibiotics: Actions, Origins, Resistance ASM Press Washington, DC 2003
  17. [19]Walsh CT Wencewicz TA Antibiotics: Challenges, Mechanisms, Opportunities ASM Press Washington, DC 2016
  18. [20]Bourne CR Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery Antibiotics 2014 3 1 28 27025730 PMC4790348
  19. [21]Wright PM Seiple IB Myers AG The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery Angew Chem, Int Ed 2014 53 8840 8869 PMC4536949 24990531
  20. [24]Coates A Antibiotic Resistance Coates A Springer Heidelberg 2012
  21. [25]Dever LA Mechanisms of Bacterial Resistance to Antibiotics Arch Intern Med 1991 151 886 2025137
  22. [26]Crofts TS Gasparrini AJ Dantas G Next-Generation Approaches to Understand and Combat the Antibiotic Resistome Nat Rev Microbiol 2017 15 422 434 28392565 PMC5681478
  23. [28]Coates A Antibiotic Resistance Coates A Springer Heidelberg 2012 211
  24. [29]Munita JM Arias CA Unit AR Santiago A De Mechanisms of Antibiotic Resistance Microb Spectr 2016 4 1 37 PMC4888801 27227291
  25. [30]Blair JMA Webber MA Baylay AJ Ogbolu DO Piddock LJV Molecular Mechanisms of Antibiotic Resistance Nat Rev Microbiol 2015 13 42 51 25435309
  26. [31]Langton KP Henderson PJF Herbert RB Antibiotic Resistance: Multidrug Efflux Proteins, a Common Transport Mechanism? Nat Prod Rep 2005 22 439 451 16047044
  27. [32]McMurry LM Petrucci REJ Levy SB Active Efflux of Tetracycline Encoded by Four Genetically Different Tetracycline Resistance Determinants in Escherichia Coli Proc Natl Acad Sci U S A 1980 77 3974 3977 7001450 PMC349750
  28. [33]Blair JMA Webber MA Baylay AJ Ogbolu DO Piddock LJV Molecular Mechanisms of Antibiotic Resistance Nat Rev Microbiol 2015 13 42 51 25435309
  29. [34]Nikaido H Multidrug Resistance in Bacteria Annu Rev Biochem 2009 78 119 146 19231985 PMC2839888
  30. [36]Langton KP Henderson PJF Herbert RB Antibiotic Resistance: Multidrug Efflux Proteins, a Common Transport Mechanism? Nat Prod Rep 2005 22 439 451 16047044
  31. [38]Mingeot-Leclercq MP Glupczynski Y Tulkens PM Aminoglycosides: Activity and Resistance Antimicrob Agents Chemother 1999 43 727 737 10103173 PMC89199
  32. [39]Phillips I Acar J Bergan T Degener J Baquero F Forsgren A Schito G-C Wiedemann B Methods for the Determination of Susceptibility of Bacteria to Antimicrobial Agents. Terminology Clin Microbiol Infect 1998 4 291 296 11864348
  33. [40]Mendelson M Balasegaram M Jinks T Pulcini C Sharland M Antibiotic Resistance Has a Language Problem Nature 2017 545 23 25 28470219
  34. [41]Repka LM Chekan JR Nair SK van der Donk WA Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes Chem Rev 2017 117 5457 5520 28135077 PMC5408752
  35. [42]Lovering F Bikker J Humblet C Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success J Med Chem 2009 52 6752 6756 19827778
  36. [44]Pawlowski AC Johnson JW Wright GD Evolving Medicinal Chemistry Strategies in Antibiotic Discovery Curr Opin Biotechnol 2016 42 108 117 27116217
  37. [45]Lipinski CA Lombardo F Dominy BW Feeney PJ Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings Adv Drug Delivery Rev 2001 46 3 26 11259830
  38. [46]Galloway WRJD Bender A Welch M Spring DR The Discovery of Antibacterial Agents Using Diversity-Oriented Synthesis Chem Commun 2009 18 2446 2462 19532856
  39. [47]Schreiber SL Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery Science 2000 287 1964 1969 10720315
  40. [48]Huigens RW III Morrison KC Hicklin RW Flood TA Jr Richter MF Hergenrother PJ A Ring-Distortion Strategy to Construct Stereochemically Complex and Structurally Diverse Compounds from Natural Products Nat Chem 2013 5 195 202 23422561 PMC3965367
  41. [49]Rafferty RJ Hicklin RW Maloof KA Hergenrother PJ Synthesis of Complex and Diverse Compounds through Ring Distortion of Abietic Acid Angew Chem, Int Ed 2014 53 220 224 24273016
  42. [50]Morrison KC Hergenrother PJ Natural Products as Starting Points for the Synthesis of Complex and Diverse Compounds Nat Prod Rep 2014 31 6 14 24219884
  43. [51]Allred TK Manoni F Harran PG Exploring the Boundaries of “ Practical ”: De Novo Syntheses of Complex Natural Product-Based Drug Candidates Chem Rev 2017 10.1021/acs.chemrev.7b00126 28603978 · DOI
  44. [52]Chou T-C Dong H Rivkin A Yoshimura F Gabarda AE Cho YS Tong WP Danishefsky SJ Design and Total Synthesis of a Superior Family of Epothilone Analogues which Eliminate Xenograft Tumors to a Nonrelapsable State Angew Chem 2003 115 4910 4915 14562342
  45. [53]Rivkin A Chou T-C Danishefsky SJ On the Remarkable Antitumor Properties of Fludelone: How we Got There Angew Chem, Int Ed 2005 44 2838 2850 15880547
  46. [54]Danishefsky S On the potential of natural products in the discovery of pharma leads: A case for reassessment Nat Prod Rep 2010 27 1114 1116 20383353
  47. [55]Wender PA Quiroz RV Stevens MC Function through Synthesis-Informed Design Acc Chem Res 2015 48 752 760 25742599 PMC4415040
  48. [56]Wender PA Verma VA Paxton TJ Pillow TH Function-Oriented Synthesis, Step Economy, and Drug Design Acc Chem Res 2008 41 40 49 18159936
  49. [57]Cordier C Morton D Murrison S Nelson A O’Leary-Steele C Natural Products as an Inspiration in the Diversity-Oriented Synthesis of Bioactive Compound Libraries Nat Prod Rep 2008 25 719 737 18663392 PMC2496956
  50. [58]Thomas GL Spandl RJ Glansdorp FG Welch M Bender A Cockfield J Lindsay JA Bryant C Brown DFJ Loiseleur O Anti-MRSA Agent Discovery Using Diversity-Oriented Synthesis Angew Chem, Int Ed 2008 47 15 2808 2812 18307176
  51. [59]Socha AM Tan NY Laplante KL Sello JK Diversity-Oriented Synthesis of Cyclic Acyldepsipeptides Leads to the Discovery of a Potent Antibacterial Agent Bioorg Med Chem 2010 18 7193 7202 20833054
  52. [60]Paciaroni NG Ratnayake R Matthews JH Norwood VM IV Arnold AC Dang LH Luesch H Huigens RW III A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine Chem – Eur J 2017 23 4327 4335 27900785 PMC5378593
  53. [61]McGuire JM Bunch RL Anderson RC Boaz HE Flynn EH Powell HM Smith JW Ilotycin, a New Antibiotic Antibiot Chemother 1952 2 281 283 24541924
  54. [62]Erythromycin: Another Antibiotic Lancet 1952 260 232 233 10.1016/S0140-6736(52)91557-2 14939901 · DOI
  55. [63]Erythromycin, New and Promising Antibiotic N Engl J Med 1952 247 267 269 10.1056/NEJM195208142470710 14947939 · DOI
  56. [64]Wiley PF Gerzon K Flynn EH Sigal MV Jr Weaver O Quarck UC Chauvette RR Monahan R Erythromycin. X. Structure of Erythromycin J Am Chem Soc 1957 79 6062 6070
  57. [65]Harris DR McGeachin SG Mills HH The Structure and Stereochemistry of Erythromycin A Tetrahedron Lett 1965 6 679 685 14295195
  58. [66]Celmer WD Stereochemical Problems in Macrolide Antibiotics Pure Appl Chem 1971 28 413 453 4947320
  59. [67]Contreras A Vázquez D Cooperative and Antagonistic Interactions of Peptidyl-tRNA and Antibiotics with Bacterial Ribosomes Eur J Biochem 1977 74 539 547 323015
  60. [68]Andersson S Kurland CG Elongating Ribosomes in Vivo Are Refractory to Erythromycin Biochimie 1987 69 901 904 3122850
  61. [69]Dunkle JA Xiong L Mankin AS Cate JHD Structures of the Escherichia coli Ribosome with Antibiotics Bound near the Peptidyl Transferase Center Explain Spectra of Drug Action Proc Natl Acad Sci U S A 2010 107 17152 17157 20876128 PMC2951456
  62. [70]Sutcliffe J Tait-Kamradt A Wondrack L Streptococcus pneumoniae and Streptococcus pyogenes Resistant to Macrolides but Sensitive to Clindamycin: A Common Resistance Pattern Mediated by an Efflux System Antimicrob Agents Chemother 1996 40 1817 1824 8843287 PMC163423
  63. [71]Felmingham D Cantón R Jenkins SG Regional Trends in Beta-Lactam, Macrolide, Fluoroquinolone and Telithromycin Resistance among Streptococcus pneumoniae Isolates 2001–2004 J Infect 2007 55 111 118 17568680
  64. [72]Wierzbowski AK Nichol K Laing N Hisanaga T Nikulin A Karlowsky JA Hoban DJ Zhanel GG Macrolide Resistance Mechanisms among Streptococcus pneumoniae Isolated over 6 Years of Canadian Respiratory Organism Susceptibility Study (CROSS) (1998–2004) J Antimicrob Chemother 2007 60 733 740 17673477
  65. [73]Lubelski J Konings WN Driessen AJM Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria Microbiol Mol Biol Rev 2007 71 463 476 17804667 PMC2168643
  66. [74]Kobayashi N Nishino K Yamaguchi A Novel Macrolide-Specific ABC-Type Efflux Transporter in Escherichia coli J Bacteriol 2001 183 5639 5644 11544226 PMC95455
  67. [75]Ojo KK Striplin MJ Ulep CC Close NS Zittle J Luis H Bernardo M Leitao J Roberts MC Staphylococcus Efflux msr(A) Gene Characterized in Streptococcus, Enterococcus, Corynebacterium, and Pseudomonas Isolates Antimicrob Agents Chemother 2006 50 1089 1091 16495276 PMC1426440
  68. [76]Blair JMA Piddock LJV Structure, Function, and Inhibition of RND Efflux Pumps in Gram-Negative Bacteria: An Update Curr Opin Microbiol 2009 12 512 519 19664953
  69. [77]Chollet R Chevalier J Bryskier A Pagès JM The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux in Enterobacter aerogenes and Escherichia coli Antimicrob Agents Chemother 2004 48 3621 3624 15328143 PMC514773
  70. [78]Wehmeier C Schuster S Fähnrich E Kern WV Bohnert JA Site-Directed Mutagenesis Reveals Amino Acid Residues in the Escherichia coli RND Efflux Pump AcrB That Confer Macrolide Resistance Antimicrob Agents Chemother 2009 53 329 330 18936189 PMC2612153
  71. [79]Canu A Malbruny B Coquemont M Davies TA Appelbaum PC Leclercq R Diversity of Ribosomal Mutations Conferring Resistance to Macrolides, Clindamycin, Streptogramin, and Telithromycin in Streptococcus pneumoniae Antimicrob Agents Chemother 2002 46 125 131 11751122 PMC126998
  72. [80]Björkholm B Sjölund M Falk PG Berg OG Engstrand L Andersson DI Mutation Frequency and Biological Cost of Antibiotic Resistance in Helicobacter pylori Proc Natl Acad Sci U S A 2001 98 14607 14612 11717398 PMC64729
  73. [81]Allen NE Macrolide Resistance in Staphylococcus aureus: Induction of Macrolide-Resistant Protein Synthesis Antimicrob Agents Chemother 1977 11 661 668 856017 PMC352046
  74. [82]Allen NE Macrolide Resistance in Staphylococcus aureus: Inducers of Macrolide Resistance Antimicrob Agents Chemother 1977 11 669 674 856018 PMC352047
  75. [83]Pestka S Vince R Lemahieu R Weiss F Fern L Unowsky J Induction of Erythromycin Resistance in Staphylococcus aureus by Erythromycin Derivatives Antimicrob Agents Chemother 1976 9 128 130 1259386 PMC429486
  76. [84]Weisblum B Insights into Erythromycin Action from Studies of Its Activity as Inducer of Resistance Antimicrob Agents Chemother 1995 39 797 805 7785974 PMC162632
  77. [85]Weisblum B Siddhikol C Lai CJ Demohn V Erythromycin-Inducible Resistane in Staphylococcus aureus: Requirements for Induction J Bacteriol 1971 106 835 847 4397638 PMC248701
  78. [86]Ounissi H Courvalin P Nucleotide Sequence of the Gene ereA Encoding the Erythromycin Esterase in Escherichia coli Gene 1985 35 271 278 3899861
  79. [87]Arthur M Autissier D Courvalin P Analysis of the Nucleotide Sequence of the ereB Gene Encoding the Erythromycin Esterase Type II Nucleic Acids Res 1986 14 4987 4999 3523438 PMC311505
  80. [88]Yong D Toleman MA Giske CG Cho HS Sundman K Lee K Walsh TR Characterization of a New Metallo-β-Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella pneumoniae Sequence Type 14 from India Antimicrob Agents Chemother 2009 53 5046 5054 19770275 PMC2786356
  81. [89]Morar M Pengelly K Koteva K Wright GD Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes Biochemistry 2012 51 1740 1751 22303981
  82. [91]Kurath P Jones PH Egan RS Perun TJ Acid Degradation of Erythromycin A and Erythromycin B Experientia 1971 27 362 5581079
  83. [92]Morimoto S Takahashi T Watanabe Y Omura S Chemical Modification of Erythromycins. I. Synthesis and Antibacterial Activity of 6-O-Methylerythromycins A J Antibiot 1984 37 187 189 6706855
  84. [94]Farrell DJ Flamm RK Sader HS Jones RN Results from the Solithromycin International Surveillance Program (2014) Anti-microb Agents Chemother 2016 60 3662 3668 PMC4879362 27044551
  85. [96]Bertrand D Bertrand S Neveu E Fernandes P Molecular Characterization of Off-Target Activities of Telithroycin: A Potential Role for Nicotinic Acetycholine Receptors Antimicrob Agents Chemo-ther 2010 54 5399 5402 PMC2981250 20855733
  86. [98]Owens B Solithromycin Rejection Chills Antibiotic Sector Nat Biotechnol 2017 35 187 188 28267725
  87. [105]Hergenrother PJ Hodgson A Judd AS Lee W-C Martin SF An Abiotic Strategy for the Enantioselective Synthesis of Erythromycin B Angew Chem, Int Ed 2003 42 3278 3281 12876743
  88. [107]Kim HC Kang SH Total Synthesis of Azithromycin Angew Chem, Int Ed 2009 48 1827 1829 19173267
  89. [108]Seiple IB Zhang Z Jakubec P Langlois-Mercier A Wright PM Hog DT Yabu K Allu SR Fukuzaki T Carlsen PN A Platform for the Discovery of New Macrolide Antibiotics Nature 2016 533 338 345 27193679 PMC6526944
  90. [110]Morales MR Mellem KT Myers AG Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis Angew Chem, Int Ed 2012 51 4568 4571 PMC3854953 22461381
  91. [113]Zhang Z Fukuzaki T Myers AG Synthesis of -Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars Angew Chem, Int Ed 2016 55 523 527 26612347
  92. [114]Tu D Blaha G Moore PB Steitz TA Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance Cell 2005 121 257 270 15851032
  93. [116]Velvadapu V Glassford I Lee M Paul T Debrosse C Klepacki D Small MC MacKerell AD Andrade RB Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin ACS Med Chem Lett 2012 3 211 215 22708010 PMC3374412
  94. [117]Velvadapu V Paul T Wagh B Klepacki D Guvench O MacKerell A Andrade RB Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Telithromycin ACS Med Chem Lett 2011 2 68 72 21643527 PMC3105755
  95. [118]Wagh B Paul T Glassford I Debrosse C Klepacki D Small MC MacKerell AD Andrade RB Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin ACS Med Chem Lett 2012 3 1013 1018 24015325 PMC3763958
  96. [119]Glassford I Lee M Wagh B Velvadapu V Paul T Sandelin G DeBrosse C Klepacki D Small MC Mackerell AD Desmethyl Macrolides: Synthesis and Evaluation of 4-Desmethyl Telithromycin ACS Med Chem Lett 2014 5 1021 1026 25221660 PMC4160760
  97. [120]Gumbart J Schreiner E Wilson DN Beckmann R Schulten K Mechanisms of SecM-Mediated Stalling in the Ribosome Biophys J 2012 103 331 341 22853911 PMC3400775
  98. [121]Washington AZ Tapadar S George A Oyelere AK Exploiting Translational Stalling Peptides in an Effort to Extend Azithromycin Interaction Within the Prokaryotic Ribosome Nascent Peptide Exit Tunnel Bioorg Med Chem 2015 23 5198 5209 26037612 PMC4536091
  99. [122]Liu F Myers AG Development of a Platform for the Discovery and Practical Synthesis of New Tetracycline Antibiotics Curr Opin Chem Biol 2016 32 48 57 27043373
  100. [124]Chopra I Roberts M Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance Microbiol Mol Biol Rev 2001 65 232 260 11381101 PMC99026
  101. [128]Burdett V Tet(M)-Promoted Release of Tetracycline from Ribosomes Is GTP Dependent J Bacteriol 1996 178 3246 3251 8655505 PMC178077
  102. [129]Trieber CA Burkhardt N Nierhaus KH Taylor DE Ribosomal Protection from Tetracycline Mediated by Tet(O): Tet(O) Interaction with Ribosomes Is GTP-Dependent Biol Chem 1998 379 847 856 9705148
  103. [130]Dönhöfer A Franckenberg S Wickles S Berninghausen O Beckmann R Wilson DN Structural Basis for TetM-Mediated Tetracycline Resistance Proc Natl Acad Sci U S A 2012 109 16900 16905 23027944 PMC3479509
  104. [132]Speer BS Bedzyk L Salyers AA Evidence That a Novel Tetracycline Resistance Gene Found on Two Bacteroides Transposons Encodes an NADP-Requiring Oxidoreductase J Bacteriol 1991 173 176 183 1846135 PMC207172
  105. [133]Caryl JA Cox G Trimble S O’Neill AJ tet(U)” is Not a Tetracycline Resistance Determinant Antimicrob Agents Chemother 2012 56 3378 3379 22491689 PMC3370814
  106. [135]Church FR Weiss J Synthesis of 7-Dimethylamino-6-Demethyl-6-Deoxytetracycline (Minocycline) via 9-Nitro-6-Demethyl-6-Deoxytetracycline J Org Chem 1971 36 723 725 5545572
  107. [136]Martell MJ Boothe JH The 6-Deoxytetracyclines. VII. Alkylated Aminotetracyclines Possessing Unique Antibacterial Activity J Med Chem 1967 10 44 46 6031702
  108. [137]Sum PE Lee VJ Testa RT Hlavka JJ Ellestad GA Bloom JD Gluzman Y Tally FP Glycylcyclines. 1. A New Generation of Potent Antibacterial Agents through Modification of 9-Aminotetracyclines J Med Chem 1994 37 184 188 8289194
  109. [138]Olson MW Ruzin A Feyfant E Rush TS III O’Connell J Bradford PA Functional, Biophysical, and Structural Bases for Antibacterial Activity of Tigecycine Antimicrob Agents Chemother 2006 50 2156 2166 16723578 PMC1479133
  110. [139]Honeyman L Ismail M Nelson ML Bhatia B Bowser TE Chen J Mechiche R Ohemeng K Verma AK Cannon EP Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline Antimicrob Agents Chemother 2015 59 7044 7053 26349824 PMC4604364
  111. [142]Gurevich AI Karapetyan MG Kolosov MN Korobko V Onoprienko VV Popravko SA Shemyakin M Synthesis of 12a-Deoxy-5a, 6-Anhydrotetracycline. The First Total Synthesis of the Naturally Occurring Tetracycline Tetrahedron Lett 1967 8 131 134 6044791
  112. [144]Muxfeldt H Haas G Hardtmann G Kathawala F Mooberry JB Vedejs E Tetracyclines. 9. Total Synthesis of Dl-Terramycin J Am Chem Soc 1979 101 689 701 5682455
  113. [148]Charest MG Lerner CD Brubaker JD Siegel DR Myers AG A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics Science 2005 308 395 398 15831754
  114. [149]Wilson RM Danishefsky SJ Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection J Org Chem 2006 71 8329 8351 17064003
  115. [151]Brubaker JD Myers AG A Practical, Enantioselective Synthetic Route to a Key Precursor to the Tetracycline Antibiotics Org Lett 2007 9 3523 3525 17691796 PMC3178443
  116. [152]Kummer DA Li D Dion A Myers AG A Practical, Convergent Route to the Key Precursor to the Tetracycline Antibiotics Chem Sci 2011 2 1710 1718 21949588 PMC3176682
  117. [155]Sun C Wang Q Brubaker JD Wright PM Lerner CD Noson K Charest M Siegel DR Wang Y Myers AG A Robust Platform for the Synthesis of New Tetracycline Antibiotics J Am Chem Soc 2008 130 17913 17927 19053822 PMC2681267
  118. [156]Sun C Hunt DK Chen CL Deng Y He M Clark RB Fyfe C Grossman TH Sutcliffe JA Xiao XY Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents J Med Chem 2015 58 4703 4712 25927406
  119. [157]Liu F Wright PM Myers AG Diastereoselective Michael–Claisen Cyclizations of γ-Oxa-A,β-Unsaturated Ketones En Route to 5-Oxatetracyclines Org Lett 2017 19 206 209 27996275
  120. [158]Xiao X-Y Hunt DK He M Achorn C Chen CL Deng Y Fyfe C Grossman TH Hogan PC O’Brien WJ Clark RB Fluorocyclines. 1. 7-Fluoro-9-Pyrrolidinoacetamido-6-Demethyl-6- Deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent J Med Chem 2012 55 597 22148514
  121. [159]Clark RB Hunt DK He M Achorn C Chen C-L Deng Y Fyfe C Grossman TH Hogan PC O’Brien WJ Fluorocyclines. 2. Optimization of the C-9 Side-Chain for Antibacterial Activity and Oral Efficacy J Med Chem 2012 55 606 622 22148555
  122. [162]Solomkin J Evans D Slepavicius A Lee P Marsh A Tsai L Sutcliffe JA Horn P Assessing the Efficacy and Safety of Eravacycline vs Ertapenem in Complicated Intra-Abdominal Infections in the Investigating Gram-Negative Infections Treated With Eravacycline (IGNITE 1) Trial: A Randomized Clinical Trial JAMA Surg 2017 152 E1 E9 27851857
  123. [163]Hutchison RD Steyn PS van Rensburg SJ Viridicatumtoxin, a New Mycotoxin from Penicillium Viridicatum Westling Toxicol Appl Pharmacol 1973 24 507 509 4122267
  124. [164]Zheng C-J Yu H-E Kim E-H Kim W-G Viridicatumtoxin B, a New Anti-MRSA Agent from Penicillium Sp. FR11 J Antibiot 2008 61 633 637 19168978
  125. [165]Inokoshi J Nakamura Y Hongbin Z Uchida R Nonaka K Masuma R Tomoda H Spirohexalines, New Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase, Produced by Penicillium Brasilianum FKI-3368 J Antibiot 2013 66 37 41 23168407
  126. [166]Nicolaou KC Nilewski C Hale CRH Ioannidou HA Elmarrouni A Koch LG Total Synthesis and Structural Revision of Viridicatumtoxin B Angew Chem, Int Ed 2013 52 8736 8741 PMC3835450 23893651
  127. [167]Nicolaou KC Hale CRH Nilewski C Ioannidou HA Elmarrouni A Nilewski LG Beabout K Wang TT Shamoo Y Total Synthesis of Viridicatumtoxin B and Analogues Thereof: Strategy Evolution, Structural Revision, and Biological Evaluation J Am Chem Soc 2014 136 12137 12160 25317739 PMC4210137
  128. [168]Nicolaou KC Liu G Beabout K McCurry MD Shamoo Y Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (−)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents J Am Chem Soc 2017 139 3736 3746 28256128 PMC5826551
  129. [169]McCormick MH Stark WM Pittenger GE Pittenger RC McGuire JM Vancomycin, a New Antibiotic. I. Chemical and Biologic Properties Antibiot Annu 1955 3 606 611 13355336
  130. [172]Levine DP Vancomycin: A History Clin Infect Dis 2006 42 S5 12 16323120
  131. [173]Courvalin P Vancomycin Resistance in Gram-Positive Cocci Clin Infect Dis 2006 42 Suppl 1 S25 34 16323116
  132. [174]Anderson S Biosynthesis of the Peptidoglycan of Bacterial Cell Walls J Biol Chem 1967 242 3180 3190 6027793
  133. [175]Sham L-T Butler EK Lebar MD Kahne D Bernhardt TG Ruiz N MurJ Is the Flippase of Lipid-Linked Precursors for Peptidoglycan Biogenesis Science (Washington, DC, U S) 2014 345 220 222 PMC4163187 25013077
  134. [176]Williams DH Waltho JP Molecular Basis of the Activity of Antibiotics of the Vancomycin Group Biochem Pharmacol 1988 37 133 141 3276316
  135. [177]Nitanai Y Kikuchi T Kakoi K Hanamaki S Fujisawa I Aoki K Crystal Structures of the Complexes between Vancomycin and Cell-Wall Precursor Analogs J Mol Biol 2009 385 1422 1432 18976660
  136. [178]Périchon B Courvalin P VanA-Type Vancomycin-Resistant Staphylococcus aureus Antimicrob Agents Chemother 2009 53 4580 4587 19506057 PMC2772335
  137. [180]Wright GD Holman TR Walsh CT Purification and Characterization of VanR and the Cytosolic Domain of VanS: A Two-Component Regulatory System Required for Vancomycin Resistance in Enterococcus faecium BM4147 Biochemistry 1993 32 5057 5063 8494882
  138. [181]Kahne D Leimkuhler C Lu W Walsh C Glycopeptide and Lipoglycopeptide Antibiotics Chem Rev 2005 105 425 448 15700951
  139. [182]McComas CC Crowley BM Boger DL Partitioning the Loss in Vancomycin Binding Affinity for D-Ala-D-Lac into Lost H-Bond and Repulsiv Lone Pair Contributions J Am Chem Soc 2003 125 9314 9315 12889959
  140. [183]Judice JK Pace JL Semi-Synthetic Glycopeptide Antibacterials Bioorg Med Chem Lett 2003 13 4165 4168 14622994
  141. [184]Leadbetter MR Adams SM Bazzini B Fatheree PR Karr DE Krause KM Lam BMT Linsell MS Nodwell MB Pace JL Hydrophobic Vancomycin Derivatives with Improved ADME Properties: Discovery of Telavancin J Antibiot 2004 57 326 336 15303493
  142. [185]Krause KM Renelli M Difuntorum S Wu TX Debabov DV Benton BM In Vitro Activity of Telavancin against Resistant Gram-Positive Bacteria Antimicrob Agents Chemother 2008 52 2647 2652 18443122 PMC2443888
  143. [186]Stryjewski ME Graham DR Wilson SE O’Riordan W Young D Lentnek A Ross DP Fowler VG Hopkins A Friedland HD Telavancin Versus Vancomycin for the Treatment of Complicated Skin and Skin-Structure Infections Caused by Gram-Positive Organisms Clin Infect Dis 2008 46 1683 1693 18444791
  144. [188]Sosio M Stinchi S Beltrametti F Lazzarini A Donadio S The Gene Cluster for the Biosynthesis of the Glycopeptide Antibiotic A40926 by Nonmuraea Species Chem Biol 2003 10 541 549 12837387
  145. [189]Candiani G Abbondi M Borgonovi M Romanò G Parenti F In-Vitro and in-Vivo Antibacterial Activity of BI 397, a New Semi-Synthetic Glycopeptide Antibiotic J Antimicrob Chemother 1999 44 179 192 10473224
  146. [190]Seltzer E Dorr MB Goldstein BP Perry M Dowell Ja Henkel T Once-Weekly Dalbavancin versus Standard-of-Care Antimicrobial Regimens for Treatment of Skin and Soft-Tissue Infections Clin Infect Dis 2003 37 1298 1303 14583862
  147. [191]Boucher HW Wilcox M Talbot GH Puttagunta S Das AF Dunne MW Once-Weekly Dalbavancin versus Daily Conventional Therapy for Skin Infection N Engl J Med 2014 370 2169 2179 24897082
  148. [193]Nicolaou KC Hughes R Cho SY Winssinger N Smethurst C Labischinski H Endermann R Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria Angew Chem, Int Ed 2000 39 3823 3828 29711708
  149. [194]Ge M Chen Z Onishi HR Kohler J Silver LL Kerns R Fukuzawa S Thompson C Kahne D Vancomycin Derivatives That Inhibit Peptidoglycan Biosynthesis Without Binding D-Ala-D-Ala Science 1999 284 507 511 10205063
  150. [195]Williams DH Bardsley B The Vancomycin Group of Antibiotics and the Fight against Resistant Bacteria Angew Chem, Int Ed 1999 38 1172 1193 29711719
  151. [196]Okano A Isley NA Boger DL Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues Chem Rev 2017 10.1021/acs.chemrev.6b00820 PMC5617763 28437097 · DOI
  152. [197]Evans DA Wood MR Trotter BW Richardson TI Barrow JC Katz JL Total Syntheses of Vancomcin and Eremomycin Aglycons Angew Chem, Int Ed 1998 37 2700 2704 29711601
  153. [204]Nicolaou KC Natarajan S Li H Jain NF Hughes R Solomon ME Ramanjulu JM Boddy CNC Takayanagi M Total Synthesis of Vancomycin Aglycon-Part 1: Synthesis of Amino Acids 4–7 and Construction of the AB-COD Ring Skeleton Angew Chem, Int Ed 1998 37 19 2708 2714 29711605
  154. [206]Nicolaou KC Jain NF Natarajan S Hughes R Solomon ME Li H Ramanjulu JM Takayanagi M Koumbis AE Bando T Total Synthesis of Vancomycin Aglycon—Part 2: Synthesis of Amino Acids 1–3 and Construction of the AB-COD-DOE Ring Skeleton Angew Chem, Int Ed 1998 37 2714 2716 29711613
  155. [207]Nicolaou KC Takayanagi M Jain NF Natarajan S Koumbis AE Bando T Ramanjulu JM Total Synthesis of Vancomycin Aglycon—Part 3: Final Stages Angew Chem, Int Ed 1998 37 2717 2719 29711623
  156. [211]Nicolaou KC Cho SY Hughes R Winssinger N Smethurst C Labischinski H Endermann R Solid- and Solution-Phase Synthesis of Vancomycin and Vancomycin Analogues with Activity against Vancomycin-Resistant Bacteria Chem – Eur J 2001 7 3798 3823 11575782
  157. [212]Boger DL Castle SL Miyazaki S Wu JH Beresis RT Loiseleur O Vancomycin CD and DE Macrocyclization and Atropisomerism Studies J Org Chem 1999 64 70 80 11674087
  158. [216]Crowley BM Boger DL Total Synthesis and Evaluation of [Ψ[CH2NH]Tpg4]Vancomycin Aglycon: Reengineering Vancomycin for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding J Am Chem Soc 2006 128 2885 2892 16506767 PMC2586002
  159. [217]Xie J Okano A Pierce JG James RC Stamm S Crane CM Boger DL Total Synthesis of [Ψ[C(=S)NH]Tpg4]-Vancomycin Aglycon, [Ψ[C(= NH)NH]Tpg4]Vancomycin Aglycon, and Related Key Compounds: Reengineering Vancomycin for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding J Am Chem Soc 2012 134 1284 1297 22188323 PMC3262083
  160. [218]Okano A Nakayama A Schammel AW Boger DL Total Synthesis of [Ψ[C(=NH)NH]Tpg4]Vancomycin and Its 4-Chlorobiphenyl)methyl Derivative: Impact of Peripheral Modifications on Vancomycin Analogues Redesigned for Dual D-Ala-D-Ala and D-Ala-D-Lac Binding J Am Chem Soc 2014 136 13522 13525 25211770 PMC4183650
  161. [219]Okano A Nakayama A Wu K Lindsey EA Schammel AW Feng Y Collins KC Boger DL Total Syntheses and Initial Evaluation of [Ψ[C(=S)NH]Tpg4]vancomycin, [Ψ[=NH)NH]Tpg4]-vancomycin, [Ψ[CH2NH]Tpg4]vancomycin, and Their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modificat J Am Chem Soc 2015 137 3693 3704 25750995 PMC4376669
  162. [220]Losey HC Jiang J Biggins JB Oberthur M Ye XY Dong SD Kahne D Thorson JS Walsh CT Incorporation of Glucose Analogs by GtfE and GtfD from the Vancomycin Biosynthetic Pathway to Generate Variant Glycopeptides Chem Biol 2002 9 1305 1314 12498883
  163. [221]Okano A Isley NA Boger DL Peripheral Modifications of [Ψ[CH2NH]Tpg4]vancomycin with Added Synergistic Mechanisms of Action Provide Durable and Potent Antibiotics Proc Natl Acad Sci U S A 2017 E5053 E5061 PMC5495262 28559345
  164. [222]Nealson KH Platt T Hastings JW Cellular Control of the Synthesis and Activity of the Bacterial Luminescent System J Bacteriol 1970 104 313 322 5473898 PMC248216
  165. [223]Eberhard A Burlingame AL Eberhard C Kenyon GL Nealson KH Oppenheimer NJ Structural Identification of Autoinducer of Photobacterium Fischeri Luciferase Biochemistry 1981 20 2444 2449 7236614
  166. [224]Fuqua WC Winans SC Greenberg EP Quorum Sensing in Bacteria: The LuxR-LuxI Family of Cell Density-Responsive Transcriptional Regulators J Bacteriol 1994 176 269 275 8288518 PMC205046
  167. [225]Fuqua C Winans SC Greenberg EP CENSUS AND CONSENSUS IN BACTERIAL ECOSYSTEMS: The LuxR-LuxI Family of Quorum-Sensing Transcriptional Regulators Annu Rev Microbiol 1996 50 727 751 8905097
  168. [226]Surette MG Miller MB Bassler BL Quorum Sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A New Family of Genes Responsible for Autoinducer Production Proc Natl Acad Sci U S A 1999 96 1639 1644 9990077 PMC15544
  169. [227]Bassler BL How Bacteria Talk to Each Other: Regulation of Gene Expression by Quorum Sensing Curr Opin Microbiol 1999 2 582 587 10607620
  170. [228]Bassler BL Losick R Bacterially Speaking Cell 2006 125 237 246 16630813
  171. [229]Waters CM Bassler BL Quorum Sensing: Communication in Bacteria Annu Rev Cell Dev Biol 2005 21 319 346 16212498
  172. [230]Bassler BL Small Talk: Cell-to-Cell Communication in Bacteria Cell 2002 109 421 424 12086599
  173. [231]Diggle SP Matthijs S Wright VJ Fletcher MP Chhabra SR Lamont IL Kong X Hider RC Cornelis P Cámara M The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment Chem Biol 2007 14 87 96 17254955
  174. [232]Withers H Swift S Williams P Quorum Sensing as an Integral Component of Gene Regulatory Networks in Gram-Negative Bacteria Curr Opin Microbiol 2001 4 186 193 11282475
  175. [233]Wilson JW Schurr MJ LeBlanc CL Ramamurthy R Buchanan KL Nickerson CA Mechanisms of Bacterial Pathogenicity Postgrad Med J 2002 78 216 224 11930024 PMC1742320
  176. [234]Winzer K Williams P Quorum Sensing and the Regulation of Virulence Gene Expression in Pathogenic Bacteria Int J Med Microbiol 2001 291 131 143 11437336
  177. [235]Cámara M Williams P Hardman A Controlling Infection by Tuning in and Turning down the Volume of Bacterial Small-Talk Lancet Infect Dis 2002 2 667 676 12409047
  178. [236]Geske GD O’Neill JC Blackwell HE Expanding Dialogues: From Natural Autoinducers to Non-Natural Analogues That Modulate Quorum Sensing in Gram-Negative Bacteria Chem Soc Rev 2008 37 1432 1447 18568169 PMC2590586
  179. [237]Praneenararat T Palmer AG Blackwell HE Chemical Methods to Interrogate Bacterial Quorum Sensing Pathways Org Biomol Chem 2012 10 8189 8199 22948815 PMC3480174
  180. [238]Galloway WRJD Hodgkinson JT Bowden SD Welch M Spring DR Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways Chem Rev 2011 111 28 67 21182299
  181. [239]Stevens AM Queneau Y Soulère L Bodman SVon Doutheau A Mechanisms and Synthetic Modulators of AHL-Dependent Gene Regulation Chem Rev 2011 111 4 27 21142091
  182. [240]Welsh MA Eibergen NR Moore JD Blackwell HE Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes J Am Chem Soc 2015 137 1510 1519 25574853 PMC4372995
  183. [241]Stacy DM Welsh Ma Rather PN Blackwell HE Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-Native N-Acyl Homoserine Lactonres ACS Chem Biol 2012 7 1719 1728 22853441 PMC3477293
  184. [242]Huse H Whiteley M 4-Quinolones: Smart Phones of the Microbial World Chem Rev 2011 111 152 159 20701272 PMC3147023
  185. [243]Williams P Cámara M Quorum Sensing and Environmental Adaptation in Pseudomonas aeruginosa: A Tale of Regulatory Networks and Multifunctional Signal Molecules Curr Opin Microbiol 2009 12 182 191 19249239
  186. [244]Borrero NV Bai F Perez C Duong BQ Rocca JR Jin S Huigens RW Phenazine Antibiotic Inspired Discovery of Potent Bromophenazine Antibacterial Agents against Staphylococcus aureus and Staphylococcus epidermidis Org Biomol Chem 2014 12 881 886 24389824
  187. [245]Garrison AT Abouelhassan Y Norwood VM Kallifidas D Bai F Nguyen MT Rolfe M Burch GM Jin S Luesch H Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis J Med Chem 2016 59 3808 3825 27018907
  188. [246]Abouelhassan Y Garrison AT Burch GM Wong W Norwood VM Huigens RW Discovery of Quinoline Small Molecules with Potent Dispersal Activity against Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis Biofilms Using a Scaffold Hopping Strategy Bioorg Med Chem Lett 2014 24 5076 5080 25264073
  189. [247]Garrison AT Abouelhassan Y Yang H Yousaf HH Nguyen TJ Huigens RW III Microwave-Enhanced Friedländer Synthesis for the Rapid Assembly of Halogenated Quinolines with Antibacterial and Biofilm Eradication Activities against Drug Resistant and Tolerant Bacteria MedChemComm 2017 8 720 724 PMC6072483 30108790
  190. [248]Thoendel M Kavanaugh JS Flack CE Horswill AR Peptide Signaling in the Staphylococci Chem Rev 2011 111 117 151 21174435 PMC3086461
  191. [249]Novick RP Geisinger E Quorum Sensing in Staphylococci Annu Rev Genet 2008 42 541 564 18713030
  192. [250]Gripenland J Netterling S Loh E Tiensuu T Toledo-Arana A Johansson J RNAs: Regulators of Bacterial Virulence Nat Rev Microbiol 2010 8 857 866 21079634
  193. [251]Mayville P Ji G Beavis R Yang H Goger M Novick RP Muir TW Structure-Activity Analysis of Synthetic Autoinducing Thiolactone Peptides from Staphylococcus aureus Responsible for Virulence Proc Natl Acad Sci U S A 1999 96 1218 1223 9990004 PMC15443
  194. [252]Wright JS Lyon GJ George Ea Muir TW Novick RP Hydrophobic Interactions Drive Ligand-Receptor Recognition for Activation and Inhibition of Staphylococcal Quorum Sensing Proc Natl Acad Sci U S A 2004 101 16168 16173 15528279 PMC528941
  195. [253]George EA Muir TW Molecular Mechanisms of Agr Quorum Sensing in Virulent ChemBioChem 2007 8 847 855 17457814
  196. [254]Wang B Muir TW Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles Cell Chem Biol 2016 23 214 224 26971873 PMC4847544
  197. [255]Tal-Gan Y Stacy DM Foegen MK Koenig DW Blackwell HE Highly Potent Inhibitors of Quorum Sensing in Staphylococcus aureus Revealed Through a Systematic Synthetic Study of the Group-III Autoinducing Peptide J Am Chem Soc 2013 135 7869 7882 23647400
  198. [256]Tal-Gan Y Ivancic M Cornilescu G Cornilescu CC Blackwell HE Structural Characterization of Native Autoinducing Peptides and Abiotic Analogues Reveals Key Features Essential for Activation and Inhibition of an AgrC Quorum Sensing Receptor in Staphylococcus aureus J Am Chem Soc 2013 135 18436 18444 24219181 PMC3887510
  199. [257]Tal-Gan Y Ivancic M Cornilescu G Yang T Blackwell HE Highly Stable, Amide-Bridged Autoinducing Peptide Analogues That Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus Angew Chem, Int Ed 2016 55 8913 8917 PMC4972187 27276693
  200. [258]Vasquez JK Tal-Gan Y Cornilescu G Tyler KA Blackwell HE Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors ChemBioChem 2017 18 413 423 28006082 PMC5505641

200 of 236 shown

Cited by

Sorted by citations

Authors
Rossiter, S. E., Fletcher, M. H., & Wuest, W. M.
Affiliations
  • Emory University (US)
  • Temple University (US)
Corresponding author
Wuest, William M.
ORCID
Venue
Chemical Reviews
Publisher
American Chemical Society (ACS)
Published
2017-09-27
Volume
117
Issue
19
Pages
12415-12474
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
DOI
10.1021/acs.chemrev.7b00283
PMC
PMC5869711
OpenAlex
W2756935148
Cited by
622
References
13
Citations by year
2026: 43 · 2025: 79 · 2024: 96 · 2023: 80 · 2022: 79 · 2021: 78 · 2020: 71 · 2019: 56 · 2018: 33 · 2017: 5 · 2016: 1
FWCI
5.73
Type
journal article
Language
en
Open access
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Division of Chemistry (CHE-1454116)
  • Temple University
  • National Institute of General Medical Sciences (R35 GM119426)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords
antibiotic resistance, natural products, total synthesis, quorum sensing inhibition, biofilm formation, narrow-spectrum antibiotics, microbiome disruption, novel antibiotics
MeSH terms
Anti-Bacterial Agents, Bacteria, Biological Products, Drug Resistance, Microbial, Microbial Sensitivity Tests, Biofilms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review