Halichondrins-antitumor polyether macrolides from a marine sponge
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Conference International Symposium on Organic Chemistry of Medicinal Natural Products, Shanghai, China, 1985-11-10–1985-11-14 Published Online: 2009-01-01 Published in Print: 1986-01-01 © 2013 Walter de Gruyter GmbH, Berlin/Boston
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Eribulin, a truncated synthetic version of halichondrin B, derived from the sponge Halichondria okadai, has clinically potential activity against pretreated metastatic breast cancer cells.
“Eribulin, a truncated synthetic version of halichondrin B, derived from the sponge Halichondria okadai [149], has clinically potential activity against pretreated metastatic breast cancer cells [150,151].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [149]
The Introduction and Structure–Activity Relationship sections identify Halichondria okadai as the sponge from which halichondrins, including halichondrin B, were isolated. The paper does not identify eribulin or describe it as a truncated synthetic version of halichondrin B. The clinical-activity clause is attached to citations [150,151], not this source. (LLM, conf=0.87)
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- Authors
- Hirata, Y., & Uemura, D.
- Affiliations
- Shizuoka University (JP)
- ORCID
- Uemura, D.
- Venue
- Pure and Applied Chemistry
- Publisher
- Walter de Gruyter GmbH
- Published
- 1986-01-01
- Volume
- 58
- Issue
- 5
- Pages
- 701-710
- ISSN
- 0033-4545 (ISSN-L)
- 1365-3075
- OpenAlex
- W2105183657
- Cited by
- 519
- References
- 0
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 22 · 2023: 18 · 2022: 15 · 2021: 24 · 2020: 22 · 2019: 28 · 2018: 25 · 2017: 20 · 2016: 27 · 2015: 41 · 2014: 31 · 2013: 19 · 2012: 31
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pure and Applied Chemistry (publishedVersion)
- Funders
- Ono Pharmaceutical
- Japan Society for the Promotion of Science (60540350)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- marine sponges, anticancer agents, natural products
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