The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks
Abstract
A theoretical model has been developed to describe the bulk-degradation behavior of model PEG- b -PLA hydrogels. Utilizing a statistical approach to predict the cleavage of cross-links within these networks, the model accounts for both structural and kinetic issues during the degradation and, from direct comparison, can accurately predict the complex erosion profiles of the cross-linked hydrogels. The mass loss profiles of the cross-linked networks are shown to depend on parameters such as the order of the hydrolysis reaction, the value of the kinetic rate constant, the number of cross-links per backbone chain, and the mass fraction of network contained in the backbone as opposed to the rest of the network. Such an accurate degradation model based on fundamental parameters allows a greater understanding of the bulk-degradation process and its controlling factors.
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Citations
Cites
Erosion kinetics of hydrolytically degradable polymers.
Tamada, J. A., & Langer, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.552 · Cited by 356
Chain-end scission in acid catalyzed hydrolysis of poly (d,l-lactide) in solution
Shih, C. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(94)00100-9 · Cited by 159
Cited by
Hydrogels in controlled release formulations: Network design and mathematical modeling
Lin, C.-C., & Metters, A. T. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.004 · Cited by 1,768
Self-citationLutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., & Hubbell, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737381100 · Cited by 1,508
Self-citationDesigning degradable hydrogels for orthogonal control of cell microenvironments
Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717
Environmental biodegradation of synthetic polymers I. Test methodologies and procedures
Eubeler, J. P., Zok, S., Bernhard, M., & Knepper, T. P. (2009) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2009.06.007 · Cited by 214
Hemicellulose-based pH-sensitive and biodegradable hydrogel for controlled drug delivery
Sun, X.-F., Wang, H.-H., Jing, Z.-X., & Mohanathas, R. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2012.10.032 · Cited by 204
Metadata
- Authors
- Metters, A. T., Bowman, C. N., & Anseth, K. S.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2000-07-12
- Volume
- 104
- Issue
- 30
- Pages
- 7043-7049
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2025581853
- Cited by
- 188
- References
- 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks. https://app.cochat.ai/papers/10.1021/jp000523t
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- Metters, A. T., Bowman, C. N., & Anseth, K. S. (2000). A Statistical Kinetic Model for the Bulk Degradation of PLA-b-PEG-b-PLA Hydrogel Networks. The Journal of Physical Chemistry B. https://doi.org/10.1021/jp000523t
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