Erosion kinetics of hydrolytically degradable polymers.
Open accessAbstract
Degradable polymers are beginning to play an increasing role as materials for environmental and medical applications. Understanding factors that control erosion, such as bond cleavage and the dissolution and diffusion of degradation products, will be critical to the future development of these materials. Erosion kinetics, photomicroscopy, and infrared spectroscopy were used to understand the erosion mechanism of two families of degradable polymers, polyanhydrides and polyesters. Polyanhydrides exhibit behavior more characteristic of surface erosion, whereas the polyesters exhibit bulk erosion patterns. Control of erosion times from a few days to several years can be achieved by a judicious choice of monomer units and bond selection.
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The overall degradation process is a complicated interplay between the intrinsic degradation kinetics and the diffusive rate of water to the polymer.
“The overall degradation process is a complicated interplay between the intrinsic degradation kinetics and the diffusive rate of water to the polymer.419,420”
From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [420]
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- Authors
- Tamada, J. A., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- ORCID
- Langer, R
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-01-15
- Volume
- 90
- Issue
- 2
- Pages
- 552-556
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC45701
- OpenAlex
- W2048567398
- Cited by
- 356
- References
- 8
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 8 · 2023: 16 · 2022: 20 · 2021: 10 · 2020: 19 · 2019: 12 · 2018: 13 · 2017: 13 · 2016: 15 · 2015: 13 · 2014: 14 · 2013: 11 · 2012: 12
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01gm044884-09a1)
- National Cancer Institute (CA52857)
- National Institute of General Medical Sciences (GM 44884)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Environmental Science › Ecological Modeling › Erosion and Abrasive Machining
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- hydrolytic degradation, degradable polymers, polyanhydrides, polyesters, surface erosion, bulk erosion, bond cleavage
- MeSH terms
- Anhydrides, Polyesters, Polymers, Refuse Disposal
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