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Logic Gates and Elementary Computing by Enzymes
Abstract
Different selected enzymes, glucose oxidase (GOx), catalase (Cat), glucose dehydrogenase (GDH), horseradish peroxidase (HRP), and formaldehyde dehydrogenase (FDH), are used alone or coupled to construct eight different logic gates. The added substrates for the respective enzymes, glucose and H(2)O(2), act as the gate inputs, while the biocatalytically generated gluconic acid or NADH are the output signals that follow the operation of the gates. Different enzyme-based gates are XOR, INHIBIT A, INHIBIT B, AND, OR, NOR, Identity and Inverter gates. By combining the AND and XOR or the XOR and INHIBIT A gates, the half-adder and half-subtractor are constructed, respectively, opening the way to elementary computing by the use of enzymes.
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Cited by
Materials learning from life: concepts for active, adaptive and autonomous molecular systems
Merindol, R., & Walther, A. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00738d · Cited by 533
All-photonic multifunctional molecular logic device
Andréasson, J., Pischel, U., Straight, S. D., Moore, T. A., Moore, A. L., & Gust, D. (2011) · Journal of the American Chemical Society · doi:10.1021/ja203456h · Cited by 350
Credi, A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200700879 · Cited by 314
Liu, Y., Zeng, Y., Liu, L., Zhuang, C., Fu, X., Huang, W., & Cai, Z. (2014) · Nature Communications · doi:10.1038/ncomms6393 · Cited by 223
Small steps towards the development of chemical artificial intelligent systems
Gentili, P. L. (2013) · RSC Advances · doi:10.1039/c3ra44657c · Cited by 70
Metadata
- Authors
- Baron, R., Lioubashevski, O., Katz, E., Niazov, T., & Willner, I.
- Venue
- The Journal of Physical Chemistry A
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-04-13
- Volume
- 110
- Issue
- 27
- Pages
- 8548-8553
- ISSN
- 1089-5639 (ISSN-L)
- 1520-5215
- OpenAlex
- W2020156614
- Cited by
- 170
- References
- 0
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baron, R., Lioubashevski, O., Katz, E., Niazov, T., & Willner, I. (2006). Logic Gates and Elementary Computing by Enzymes. The Journal of Physical Chemistry A. https://doi.org/10.1021/jp0568327
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