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Gold Nanoparticle Based FRET Asssay for the Detection of DNA Cleavage
Abstract
We report gold nanoparticle based FRET assay to monitor the cleavage of DNA by nucleases. Fluorescence signal enhancement is observed by a factor of 120 after the cleavage reaction in the presence of S1 nuclease. The mechanism of distant dependent fluorescence quenching has been discussed. Our experimental results on distance dependent fluorescence quenching match quite well with theoretical findings obtained from the fluorescence quenching model by Gersten and Nitzan (Surf. Sci. 1985, 158, 165). Our experimental observation paradigm for the design of optical based molecular ruler strategies at distances more than double the distances achievable using traditional dipole-dipole Columbic energy transfer based methods.
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Cited by
Gold Nanoparticles in Chemical and Biological Sensing
Saha, K., Agasti, S. S., Kim, C., Li, X., & Rotello, V. M. (2012) · Chemical Reviews · doi:10.1021/cr2001178 · Cited by 4,620
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs
RAY, P. C., YU, H., & FU, P. P. (2009) · Journal of Environmental Science and Health, Part C · doi:10.1080/10590500802708267 · Cited by 936
Self-citationNoble Metal Nanoparticles for Biosensing Applications
Doria, G., Conde, J., Veigas, B., Giestas, L., Almeida, C., Assunção, M., Rosa, J., & Baptista, P. V. (2012) · Sensors · doi:10.3390/s120201657 · Cited by 708
Nanostructured Sensors for Detection of Heavy Metals: A Review
Li, M., Gou, H., Al-Ogaidi, I., & Wu, N. (2013) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc400019a · Cited by 606
Selective Detection of Mercury (II) Ion Using Nonlinear Optical Properties of Gold Nanoparticles
Darbha, G. K., Singh, A. K., Rai, U. S., Yu, E., Yu, H., & Chandra Ray, P. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801412b · Cited by 434
Self-citationConde, J., Dias, J. T., Grazú, V., Moros, M., Baptista, P. V., & de la Fuente, J. M. (2014) · Frontiers in Chemistry · doi:10.3389/fchem.2014.00048 · Cited by 425
Adsorption of DNA onto gold nanoparticles and graphene oxide: surface science and applications
Liu, J. (2012) · Physical Chemistry Chemical Physics · doi:10.1039/c2cp41186e · Cited by 408
Gold nanoparticle-based signal amplification for biosensing
Cao, X., Ye, Y., & Liu, S. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.05.027 · Cited by 393
Schäferling, M., & Nagl, S. (2011) · Methods in Molecular Biology · doi:10.1007/978-1-61779-043-0_19 · Cited by 22
Metadata
- Authors
- Ray, P. C., Fortner, A., & Darbha, G. K.
- Venue
- The Journal of Physical Chemistry B
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-10-01
- Volume
- 110
- Issue
- 42
- Pages
- 20745-20748
- ISSN
- 1520-5207 (ISSN-L)
- 1520-6106
- OpenAlex
- W2044076113
- Cited by
- 171
- References
- 0
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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