Cited by 90Photochemistry and Electron Transfer StudiesPhotodynamic Therapy Research StudiesLuminescence and Fluorescent Materials

Triplet Formation of 4-Thiothymidine and Its Photosensitization to Oxygen Studied by Time-Resolved Thermal Lensing Technique

Harada, Yosuke, Suzuki, Tadashi, Ichimura, Teijiro, Xu, Yao-Zhong·2007·The Journal of Physical Chemistry B

Abstract

Excited-state dynamics of 4-thiothymidine (S4-TdR) and its photosensitization to molecular oxygen in solution with UVA irradiation were investigated. Absorption and emission spectra measurements revealed that UVA photolysis of S4-TdR gives rise to a population of T1(pipi*), following S2(pipi*) --> S1(npi*) internal conversion. In transient absorption measurement, the 355 nm laser photolysis gave broad absorption (380-600 nm) bands of triplet S4-TdR. The time-resolved thermal lensing (TRTL) signal of S4-TdR containing the thermal component due to decay of triplet S4-TdR was clearly observed by the 355 nm laser excitation. The quantum yield for S1 --> T1 intersystem crossing was estimated to be unity by a triplet quenching experiment with potassium iodide. In the presence of molecular oxygen, the photosensitization from triplet S4-TdR gave rise to singlet oxygen O2 (1Deltag) with a quantum yield of 0.50. Therapeutic implications of such singlet oxygen formation are discussed.

Integrity signals

Registry

Crossref · 10.1021/jp0678094

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • High phototoxicity is rationalized by oxygen-independent formation of DNA photoproducts including S5 thietane derivative, a 6-4PP analogue, through photocycloaddition with vicinal thymine and putative ICLs.

    “This was rationalized in terms of oxygenindependent formation of DNA photoproducts including an expected S5 thietane derivative, a 6-4PP analogue (227), through photocycloaddition with vicinal thymine and putative ICLs (228) that however remain to be characterized.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Harada, Y., Suzuki, T., Ichimura, T., & Xu, Y.-Z.
Affiliations
Tokyo Institute of Technology (JP)
Corresponding author
Suzuki, Tadashi
Venue
The Journal of Physical Chemistry B
Published
2007-04-18
Volume
111
Issue
19
Pages
5518-5524
ISSN
  • 1520-5207 (ISSN-L)
  • 1520-6106
OpenAlex
W2072509880
Cited by
90
References
29
Citations by year
2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 2
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Physical Chemistry B (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research Online (The Open University) (submittedVersion)
Topics
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Keywords
4-thiothymidine, triplet formation, intersystem crossing, singlet oxygen, photosensitization, excited-state dynamics, triplet quenching, potassium iodide, transient absorption spectroscopy, quantum yield
MeSH terms
Hot Temperature, Oxygen, Photochemistry, Thymidine, Time Factors, Molecular Structure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review