The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide−Silica Core Suitable for Both MR Imaging and Photothermal Therapy
Open accessAbstract
We describe the synthesis, characterization, and use of hybrid nanoparticles with a superparamagnetic iron oxide (SPIO)−silica core and a gold nanoshell. These multifunctional nanoparticles, designated SPIO−Au nanoshells, displayed superparamagnetic characteristics and a significant absorbance in the near-infrared (NIR) region of the electromagnetic spectrum. In addition, they exhibited high transverse relaxivities, R 2, and a large R 2 / R 1 ratio, and therefore, they could be imaged by MRI to obtain T 2 -weighted images. Moreover, the SPIO−Au nanoshells showed efficient photothermal effects when exposed to NIR light. The use of SPIO−Au nanoshells, with their combination of unique magnetic and optical properties, should enhance the efficacy of nanoshell-mediated photothermal therapy by making it possible to direct more nanoparticles to tumors through the application of external magnetic field and by permitting real-time in vivo MRI imaging of the distribution of the nanoparticles before, during, and after photothermal therapy.
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Cites
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Metadata
- Authors
- Ji, X., Shao, R., Elliott, A. M., Stafford, R. J., Esparza-Coss, E., Bankson, J. A., Liang, G., Luo, Z.-P., Park, K., Markert, J. T., & Li, C.
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-04-06
- Volume
- 111
- Issue
- 17
- Pages
- 6245-6251
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W2083876006
- Cited by
- 326
- References
- 25
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
