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Direct Evidence for Hydroxyl Radical Scavenging Activity of Cerium Oxide Nanoparticles
Abstract
Cerium oxide (CeO 2 ) nanoparticles have been considered as excellent antioxidants and have become a focus of numerous studies. However, the mechanism behind the antioxidant role in the complex biological system has not been well-understood. In this work, direct evidence for the hydroxyl radical (•OH) scavenging activity of CeO 2 nanoparticles was established by a simple photometric system in vitro. When methyl violet (MV) reacted with hydroxyl radical, the absorbance change indicated the hydroxyl radical level. The presence of CeO 2 nanoparticles protected MV by competitively reacting with the •OH, so their hydroxyl radical scavenging activity was directly seen through the absorbance change. This activity was also proved to be size-dependent and was believed to have a close correlation with Ce 3+ at the surface of the particles.
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Cited by
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
Wei, H., & Wang, E. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35486e · Cited by 3,779
Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine
Das, S., Dowding, J. M., Klump, K. E., McGinnis, J. F., Self, W., & Seal, S. (2013) · Nanomedicine · doi:10.2217/nnm.13.133 · Cited by 561
Wu, H., Tito, N., & Giraldo, J. P. (2017) · ACS Nano · doi:10.1021/acsnano.7b05723 · Cited by 533
Cerium Oxide Nanoparticles: A Brief Review of Their Synthesis Methods and Biomedical Applications
Dhall, A., & Self, W. (2018) · Antioxidants · doi:10.3390/antiox7080097 · Cited by 482
Zatoń, M., Rozière, J., & Jones, D. J. (2017) · Sustainable Energy & Fuels · doi:10.1039/c7se00038c · Cited by 435
Metadata
- Authors
- Xue, Y., Luan, Q., Yang, D., Yao, X., & Zhou, K.
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-03-01
- Volume
- 115
- Issue
- 11
- Pages
- 4433-4438
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W2331230472
- Cited by
- 377
- References
- 0
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xue, Y., Luan, Q., Yang, D., Yao, X., & Zhou, K. (2011). Direct Evidence for Hydroxyl Radical Scavenging Activity of Cerium Oxide Nanoparticles. The Journal of Physical Chemistry C. https://doi.org/10.1021/jp109819u
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