The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Pharmaceutical Processing with Supercritical Carbon Dioxide
Abstract
Replacement of traditional solvents with "environmentally benign" carbon dioxide is receiving increased attention in pharmaceutical processing. Among the reported applications, particle formation with dense carbon dioxide and the "clean" synthesis of drug compounds using carbon dioxide as a reaction medium hold immense potential for large-scale application in the pharmaceutical industry. This paper provides an overview of these rapidly emerging technologies along with examples of the wide variety of relatively contaminant-free pharmaceutical compounds that have been processed via these technologies on a laboratory scale. Challenges facing successful implementation in practice include demonstration of continuous production and harvesting of particles with desired and reproducible product characteristics. Mathematical models aimed at a better fundamental understanding of the underlying thermophysical phenomena are essential for rational design and scale-up of these technologies.
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Citations
Cites
Supercritical Fluid Extraction
(2017) · Natural Food Flavors and Colorants · doi:10.1002/9781119114796.ch9 · Cited by 772
Dispersion Polymerizations in Supercritical Carbon Dioxide
DeSimone, J. M., Maury, E. E., Menceloglu, Y. Z., McClain, J. B., Romack, T. J., & Combes, J. R. (1994) · Science · doi:10.1126/science.265.5170.356 · Cited by 647
Water-in-Carbon Dioxide Microemulsions: An Environment for Hydrophiles Including Proteins
Johnston, K. P., Harrison, K. L., Clarke, M. J., Howdle, S. M., Heitz, M. P., Bright, F. V., Carlier, C., & Randolph, T. W. (1996) · Science · doi:10.1126/science.271.5249.624 · Cited by 555
Supercritical fluid extraction
Clifford, A. A., & Bartle, K. D. (1993) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.280580320 · Cited by 357
Polymeric materials formed by precipitation with a compressed fluid antisolvent
Dixon, D. J., Johnston, K. P., & Bodmeier, R. A. (1993) · AIChE Journal · doi:10.1002/aic.690390113 · Cited by 308
Formation of microparticulate protein powder using a supercritical fluid antisolvent
Yeo, S., Lim, G., Debendetti, P. G., & Bernstein, H. (1993) · Biotechnology and Bioengineering · doi:10.1002/bit.260410308 · Cited by 305
Design of Nonionic Surfactants for Supercritical Carbon Dioxide
McClain, J. B., Betts, D. E., Canelas, D. A., Samulski, E. T., DeSimone, J. M., Londono, J. D., Cochran, H. D., Wignall, G. D., Chillura-Martino, D., & Triolo, R. (1996) · Science · doi:10.1126/science.274.5295.2049 · Cited by 278
Enzymatic catalysis in a supercritical fluid
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Cited by
Polar Attributes of Supercritical Carbon Dioxide
Raveendran, P., Ikushima, Y., & Wallen, S. L. (2005) · Accounts of Chemical Research · doi:10.1021/ar040082m · Cited by 316
Hile, D. D., Amirpour, M. L., Akgerman, A., & Pishko, M. V. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00268-0 · Cited by 210
Metadata
- Authors
- Subramaniam, B., Rajewski, R. A., & Snavely, K.
- Venue
- Journal of Pharmaceutical Sciences
- Publisher
- American Geophysical Union (AGU)
- Published
- 1997-08
- Volume
- 86
- Issue
- 8
- Pages
- 885-890
- ISSN
- 0022-3549 (ISSN-L)
- OpenAlex
- W2058979628
- Cited by
- 444
- References
- 16
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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