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Cited by 356

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Polymeric Thin Films That Resist the Adsorption of Proteins and the Adhesion of Bacteria

Chapman, Robert G., Ostuni, Emanuele, Liang, Michael N., Meluleni, Gloria, Kim, Enoch, Yan, Lin, Pier, Gerald, Warren, H. Shaw, Whitesides, George M.·2001·Langmuir

Abstract

This paper describes the design and preparation of thin polymeric films that resist the adsorption of proteins and the adhesion of bacteria to an extent comparable to, or better than, self-assembled monolayers (SAMs) that present tri(ethylene glycol) groups. These polymeric films were prepared by the reaction of a polyamine, for example, poly(ethylenimine), with a SAM that presented interchain carboxylic anhydride groups, and by the subsequent conversion of the amino groups of the polymer to amido groups on reaction with acyl chlorides. Polyamines functionalized with acetyl chloride produced films that resisted the adsorption of protein and the adhesion of bacteria to a useful extent. Functionalization of the polyamine with acyl chlorides that were derivatives of oligo(ethylene glycol) resulted in films that were 1−10 times more resistant than those obtained by acetylation. The removal of hydrogen bond donor groups from the surface of the polyamines upon acylation seems to be important for the generation of films that resist the attachment of proteins and bacteria.

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Metadata

Authors
Chapman, R. G., Ostuni, E., Liang, M. N., Meluleni, G., Kim, E., Yan, L., Pier, G., Warren, H. S., & Whitesides, G. M.
Venue
Langmuir
Published
2001-01-26
Volume
17
Issue
4
Pages
1225-1233
ISSN
  • 0743-7463 (ISSN-L)
  • 1520-5827
OpenAlex
W1977054660
Cited by
356
References
28
FWCI
12.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Polymeric Thin Films That Resist the Adsorption of Proteins and the Adhesion of Bacteria. https://app.cochat.ai/papers/10.1021/la001222d
The paper
Chapman, R. G., Ostuni, E., Liang, M. N., Meluleni, G., Kim, E., Yan, L., Pier, G., Warren, H. S., & Whitesides, G. M. (2001). Polymeric Thin Films That Resist the Adsorption of Proteins and the Adhesion of Bacteria. Langmuir. https://doi.org/10.1021/la001222d

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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