The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Adsorption of Proteins to Hydrophobic Sites on Mixed Self-Assembled Monolayers
Abstract
This paper describes a technique that uses mixed self-assembled monolayers of two alkanethiolates ( - S(CH 2 ) 11 (OCH 2 CH 2 ) 6 OR, R = a hydrophobic group, and - S(CH 2 ) 11 (OCH 2 CH 2 ) n OH, n = 3, 6, EG n OH), in combination with surface plasmon resonance spectroscopy, to study the influence of the size and shape of R, and its density at the surface, on the hydrophobic adsorption of proteins at solid−liquid interfaces. Detailed results were obtained for β-galactosidase, carbonic anhydrase, lysozyme, and RNase A using R = C(C 6 H 5 ) 3, CH(C 6 H 5 ) 2, and CH 2 (C 6 H 5 ). A hard-sphere model is used to rationalize the adsorption; this model, although very approximate, helps to interpret qualitative trends in the data. Using this model, the extent to which adsorbed proteins undergo conformational rearrangements appears to depend on the density of the hydrophobic groups at the surface and on the concentration of protein in solution. This paper describes the first step toward the development of a system that will allow the study of hydrophobic interactions of proteins with surfaces presenting organic groups of well-defined shape.
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Cites
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Printing Proteins as Microarrays for High-Throughput Function Determination
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Self-Assembled Organic Monolayers: Model Systems for Studying Adsorption of Proteins at Aurfaces
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Self-citationEffect of Surface Wettability on the Adsorption of Proteins and Detergents
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Self-citationArginine-Mediated RNA Recognition: the Arginine Fork
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Cited by
Protein adsorption in three dimensions
Vogler, E. A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.059 · Cited by 585
Nanomaterials for Neural Interfaces
Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504
Gironès, M., Bolhuis-Versteeg, L. A. M., Lammertink, R. G. H., & Wessling, M. (2006) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2006.03.006 · Cited by 22
Metadata
- Authors
- Ostuni, E., Grzybowski, B. A., Mrksich, M., Roberts, C. S., & Whitesides, G. M.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-01-17
- Volume
- 19
- Issue
- 5
- Pages
- 1861-1872
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2082912875
- Cited by
- 261
- References
- 32
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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