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Directed Movement of Vascular Smooth Muscle Cells on Gradient-Compliant Hydrogels
Abstract
Current solutions in the treatment of cardiovascular disease include angioplasty and the insertion of stents, but a large number of these cases result in restenosis. Biomaterial coatings that control vascular smooth muscle cell migration are therefore desirable. In this study, we describe a novel method to create substrata with defined gradients in mechanical compliance using photopolymerization and patterning. Cell speed was found to be 53 ± 2.6 μm/h on a substrate with a Young's modulus of 15 kPa compared to 40 ± 3.1 μm/h for a 28 kPa substratum ( P < 0.005). We demonstrate that vascular smooth muscle cells undergo direct migration on radial-gradient-compliant substrata from soft to stiff regions of the substrate and that cells accumulate in the stiff regions after 24 h. Our results show that the pattern of the compliance gradient is important and that substrate compliance may be a key design parameter for modulation of cell migration for vascular tissue engineering applications.
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Citations
Cites
Cell Movement Is Guided by the Rigidity of the Substrate
Lo, C.-M., Wang, H.-B., Dembo, M., & Wang, Y.-L. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76279-5 · Cited by 3,289
Introduction to Physical Polymer Science
Sperling, L. H. (2005) · doi:10.1002/0471757128 · Cited by 2,917
Cited by
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569
Preparation of Hydrogel Substrates with Tunable Mechanical Properties
Tse, J. R., & Engler, A. J. (2010) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb1016s47 · Cited by 1,070
Wong, J. Y., Leach, J. B., & Brown, X. Q. (2004) · Surface Science · doi:10.1016/j.susc.2004.06.186 · Cited by 323
Self-citationSynthetic Materials in the Study of Cell Response to Substrate Rigidity
Nemir, S., & West, J. L. (2010) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9811-1 · Cited by 318
Gavara, N., & Chadwick, R. S. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.163 · Cited by 317
Metadata
- Authors
- Wong, J. Y., Velasco, A., Rajagopalan, P., & Pham, Q.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2003-01-09
- Volume
- 19
- Issue
- 5
- Pages
- 1908-1913
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1984724534
- Cited by
- 455
- References
- 2
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wong, J. Y., Velasco, A., Rajagopalan, P., & Pham, Q. (2003). Directed Movement of Vascular Smooth Muscle Cells on Gradient-Compliant Hydrogels. Langmuir. https://doi.org/10.1021/la026403p
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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