The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gold Nanoparticles as Carriers for Efficient Transmucosal Insulin Delivery
Abstract
Nanomaterials have gained tremendous importance in biology and medicine because they can be used as carriers for delivering small molecules such as drugs, proteins, and genes. We report herein the binding of the hormone insulin to gold nanoparticles and its application in transmucosal delivery for the therapeutic treatment of diabetes mellitus. Insulin was loaded onto bare gold nanoparticles and aspartic acid-capped gold nanoparticles and delivered in diabetic Wistar rats by both oral and intranasal (transmucosal) routes. Our principle observations are that there is a significant reduction of blood glucose levels (postprandial hyperglycemia) when insulin is delivered using gold nanoparticles as carriers by the transmucosal route in diabetic rats. Furthermore, control of postprandial hyperglycemia by the intranasal delivery protocol is comparable to that achieved using the standard subcutaneous administration used for type I diabetes mellitus, thus showing considerable promise for further development.
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Citations
Cites
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Cited by
Gold nanoparticles: opportunities and challenges in nanomedicine
Arvizo, R., Bhattacharya, R., & Mukherjee, P. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425241003777010 · Cited by 538
Emerging micro- and nanotechnology based synthetic approaches for insulin delivery
Mo, R., Jiang, T., Di, J., Tai, W., & Gu, Z. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60436e · Cited by 386
Nanomedicine and drug delivery: a mini review
Mirza, A. Z., & Siddiqui, F. A. (2014) · International Nano Letters · doi:10.1007/s40089-014-0094-7 · Cited by 353
Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment.
Wong, C. Y., Al-Salami, H., & Dass, C. R. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.003 · Cited by 257
Metadata
- Authors
- Joshi, H. M., Bhumkar, D. R., Joshi, K., Pokharkar, V., & Sastry, M.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-03
- Volume
- 22
- Issue
- 1
- Pages
- 300-305
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W2048893269
- Cited by
- 232
- References
- 1
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
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