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Zwitterion-Stabilized Silica Nanoparticles: Toward Nonstick Nano
Open accessAbstract
Using a short-chain zwitterionic organosiloxane, silica nanoparticles were stabilized against aggregation by high ionic strength and/or proteins. Turbidimetry and dynamic light scattering showed that "zwitterated" nanoparticles did not exhibit a significant increase in hydrodynamic radius. When challenged with 3 M NaCl or 50% fetal bovine serum, aggregation was inhibited for at least 24 h, longer with mild heat treatment, which produced nanoparticles with zero net surface charge. These findings suggest "zwitteration" of silica-capped nanoparticles provides excellent stability for in vivo circulation diagnostics and therapies.
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Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Luk, Y.-Y., Kato, M., & Mrksich, M. (2000) · Langmuir · doi:10.1021/la0004653 · Cited by 414
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Nanoparticle decoration with surfactants: Molecular interactions, assembly, and applications
Heinz, H., Pramanik, C., Heinz, O., Ding, Y., Mishra, R. K., Marchon, D., Flatt, R. J., Estrela-Lopis, I., Llop, J., Moya, S., et al. (2017) · Surface Science Reports · doi:10.1016/j.surfrep.2017.02.001 · Cited by 608
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Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine
Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., & Chen, C. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02277 · Cited by 284
Durfee, P. N., Lin, Y.-S., Dunphy, D. R., Muñiz, A. J., Butler, K. S., Humphrey, K. R., Lokke, A. J., Agola, J. O., Chou, S. S., Chen, I.-M., et al. (2016) · ACS Nano · doi:10.1021/acsnano.6b02819 · Cited by 219
Metadata
- Authors
- Estephan, Z. G., Jaber, J. A., & Schlenoff, J. B.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-10-13
- Volume
- 26
- Issue
- 22
- Pages
- 16884-16889
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1969532160
- Cited by
- 172
- References
- 2
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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