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Mesoporous Silica Nanoparticle-Supported Lipid Bilayers (Protocells) for Active Targeting and Delivery to Individual Leukemia Cells
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Lipid-coated mesoporous silica particles have been loaded with a variety of imaging agents, chemotherapeutics, and phototherapy agents for both in vitro and in vivo work.
“To date, lipid-coated mesoporous silica particles have been loaded with a variety of imaging agents, chemotherapeutics, and phototherapy agents for both in vitro and in vivo work (Mackowiak et al., 2013; Wang et al., 2013; Durfee et al., 2016; Su et al., 2017).”
From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Durfee et al., 2016
The Protocell Cargo Loading and Delivery to Targeted Cells section reports fluorescent cargo delivery in vitro and in a live chick-embryo model, and the Conclusions report delivery of the chemotherapeutic gemcitabine in vitro. The cited paper does not establish loading with phototherapy agents, and it distinguishes its ex ovo embryo work from future in vivo leukemia studies. (LLM, conf=0.88)
Experimental — accuracy not yet measuredPore size, pore chemistry, and overall particle size can be individually tailored, allowing for the loading of various types of cargo.
“In addition, pore size, pore chemistry, and overall particle size can be individually tailored, allowing for the loading of various types of cargo (Du et al., 2014; Durfee et al., 2016).”
From Delivering CRISPR: a review of the challenges and approaches (2018) · cites this paper as Durfee et al., 2016
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Sorted by citations
Delivering CRISPR: a review of the challenges and approaches
Lino, C. A., Harper, J. C., Carney, J. P., & Timlin, J. A. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1474964 · Cited by 1,185
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Metadata
- Authors
- Durfee, P. N., Lin, Y.-S., Dunphy, D. R., Muñiz, A. J., Butler, K. S., Humphrey, K. R., Lokke, A. J., Agola, J. O., Chou, S. S., Chen, I.-M., Wharton, W., Townson, J. L., Willman, C. L., & Brinker, C. J.
- Affiliations
- Chemical and Biological Engineering, University of New Mexico, 210 University Blvd NE, Albuquerque, New Mexico 87131-0001, United States
- Internal Medicine, University of New Mexico, MSC10 5550, 1 University of New Mexico, Albuquerque, New Mexico 87131, United States
- Center for Micro-Engineered Materials, Advanced Materials Laboratory, University of New Mexico, MSC04 2790, 1001 University Blvd SE, Suite 103, Albuquerque, New Mexico 87106, United States
- Health Sciences Center, Biochemistry and Molecular Biology, University of New Mexico, MSC08 4670, 1 University of New Mexico, Albuquerque, New Mexico 87131-5001, United States
- Biomedical Engineering, Vanderbilt University, 2301 Vanderbilt Place, Nashville, Tennessee 37235-1826, United States
- Advanced Materials Laboratory, Sandia National Laboratories, 1001 University Blvd. SE, Suite 100, Albuquerque, New Mexico 87106, United States
- Department of Pathology, University of New Mexico, MSC08 4640, 1 University of New Mexico, Albuquerque, New Mexico 87131-0001, United States
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2016-07-25
- Volume
- 10
- Issue
- 9
- Pages
- 8325-8345
- ISSN
- 1936-0851
- 1936-086X
- Cited by
- 219
- References
- 11
- Language
- en
- Funders
- National Cancer Institute (U01 CA151792-01)
- Division of Biological Infrastructure (DBI-1266377)
- Air Force Office of Scientific Research (FA 9550-1-14-066)
- University of New Mexico
- Laboratory Directed Research and Development
- Division of Chemical, Bioengineering, Environmental, and Transport Systems (1344298)
- Leukemia and Lymphoma Society (7010-14)
- Gabrielle’s Angel Foundation
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