The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular Simulation Studies of Protein Interactions with Zwitterionic Phosphorylcholine Self-Assembled Monolayers in the Presence of Water
Abstract
Molecular simulations were performed to study the interactions between a protein (lysozyme, LYZ) and phosphorylcholine-terminated self-assembled monolayers (PC-SAMs) in the presence of explicit water molecules and ions. The results show that the water molecules above the PC-SAM surface create a strong repulsive force on the protein as it approaches the surface. The structural and dynamic properties of the water molecules above the PC-SAM surface were analyzed to provide information regarding the role of hydration in surface resistance to protein adsorption. It can be seen from residence time dynamics that the water molecules immediately above the PC-SAM surface are significantly slowed down as compared to bulk water, suggesting that the PC-SAM surface generates a tightly bound, structured water layer around its head groups. Moreover, the orientational distribution and reorientational dynamics of the interfacial water molecules near the PC-SAM surface were found to have the ionic solvation nature of the PC head groups. These properties were also compared to those obtained previously for an oligo(ethylene glycol) (OEG) SAM system and bulk water.
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Citations
Cites
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
Ostuni, E., Chapman, R. G., Holmlin, R. E., Takayama, S., & Whitesides, G. M. (2001) · Langmuir · doi:10.1021/la010384m · Cited by 1,799
Biomaterials: Where We Have Been and Where We Are Going
Ratner, B. D., & Bryant, S. J. (2004) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.6.040803.140027 · Cited by 1,507
The Structure of Zwitterionic Phosphocholine Surfactant Monolayers
Yaseen, M., Lu, J. R., Webster, J. R. P., & Penfold, J. (2006) · Langmuir · doi:10.1021/la053316z · Cited by 92
Cited by
Zhao, J., Shi, Q., Luan, S., Song, L., Yang, H., Shi, H., Jin, J., Li, X., Yin, J., & Stagnaro, P. (2011) · Journal of Membrane Science · doi:10.1016/j.memsci.2010.10.046 · Cited by 208
The Foreign Body Response Demystified
Chandorkar, Y., K, R., & Basu, B. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00252 · Cited by 201
Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction
Noskovicova, N., Hinz, B., & Pakshir, P. (2021) · Cells · doi:10.3390/cells10071794 · Cited by 184
Metadata
- Authors
- He, Y., Hower, J., Chen, S., Bernards, M. T., Chang, Y., & Jiang, S.
- Venue
- Langmuir
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-08-09
- Volume
- 24
- Issue
- 18
- Pages
- 10358-10364
- ISSN
- 0743-7463 (ISSN-L)
- 1520-5827
- OpenAlex
- W1982044972
- Cited by
- 365
- References
- 3
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- He, Y., Hower, J., Chen, S., Bernards, M. T., Chang, Y., & Jiang, S. (2008). Molecular Simulation Studies of Protein Interactions with Zwitterionic Phosphorylcholine Self-Assembled Monolayers in the Presence of Water. Langmuir. https://doi.org/10.1021/la8013046
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