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Cited by 258

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Film Thickness Dependence of Protein Adsorption from Blood Serum and Plasma onto Poly(sulfobetaine)-Grafted Surfaces

Yang, Wei, Chen, Shengfu, Cheng, Gang, Vaisocherová, Hana, Xue, Hong, Li, Wei, Zhang, Jinli, Jiang, Shaoyi·2008·Langmuir

Abstract

In this work, we investigate protein adsorption from single protein solutions and complex media such as 100% blood serum and plasma onto poly(sulfobetaine methacrylate) (polySBMA)-grafted surfaces via atom transfer radical polymerization (ATRP) at varying film thicknesses. It is interesting to observe that protein adsorption exhibits a minimum at a medium film thickness. Results show that the surface with 62 nm polySBMA brushes presents the best nonfouling character in 100% blood serum and plasma although all of these surfaces are highly resistant to nonspecific protein adsorption from single fibrinogen and lysozyme solutions. Surface resistance to 100% blood serum or plasma is necessary for many applications from blood-contacting devices to drug delivery. This work provides a new in vitro evaluation standard for the application of biomaterials in vivo.

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Metadata

Authors
Yang, W., Chen, S., Cheng, G., Vaisocherová, H., Xue, H., Li, W., Zhang, J., & Jiang, S.
Venue
Langmuir
Published
2008-08-02
Volume
24
Issue
17
Pages
9211-9214
ISSN
  • 0743-7463 (ISSN-L)
  • 1520-5827
OpenAlex
W2012806326
Cited by
258
References
2
FWCI
7.83
Type
journal article
Language
en
Open access
closed

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