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Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters

Halperin, A.·1999·Langmuir

Abstract

The adsorption of model proteins onto brush-coated surfaces can occur via two modes. Primary adsorption at the surface, where short range attraction is dominant, is important for small proteins and may be repressed by increasing the grafting density. Secondary adsorption, due to van der Waals attraction, occurs at the outer edge of the brush. Large rodlike proteins are likely to adsorb in this fashion. This mode may be repressed by increasing the brush thickness. The thermodynamics and kinetics of adsorption of model proteins are considered within a simple analytical theory distinguishing between the different adsorption mechanisms of small and big proteins.

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Metadata

Authors
Halperin, A.
Venue
Langmuir
Published
1999-03-01
Volume
15
Issue
7
Pages
2525-2533
ISSN
  • 0743-7463 (ISSN-L)
  • 1520-5827
OpenAlex
W2044000481
Cited by
482
References
0
FWCI
10.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters. https://app.cochat.ai/papers/10.1021/la981356f
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Halperin, A. (1999). Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters. Langmuir. https://doi.org/10.1021/la981356f

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