The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP
Open accessAbstract
Graft-through ring-opening metathesis polymerization (ROMP) using ruthenium N-heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control. Here we report the first bivalent-brush polymers; these materials were prepared by graft-through ROMP of drug-loaded polyethylene-glycol (PEG) based macromonomers (MMs). Anticancer drugs doxorubicin (DOX) and camptothecin (CT) were attached to a norbornene-alkyne-PEG MM via a photocleavable linker. ROMP of either or both drug-loaded MMs generated brush homo- and co-polymers with low polydispersities and defined molecular weights. Release of free DOX and CT from these materials was initiated by exposure to 365 nm light. All of the CT and DOX polymers were at least 10-fold more toxic to human cancer cells after photoinitiated drug release while a copolymer carrying both CT and DOX displayed 30-fold increased toxicity upon irradiation. Graft-through ROMP of drug-loaded macromonomers provides a general method for the systematic study of structure-function relationships for stimuli-responsive polymers in biological systems.
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Cites
Nanocarriers as an emerging platform for cancer therapy
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Hawker, C. J., & Wooley, K. L. (2005) · Science · doi:10.1126/science.1109778 · Cited by 1,298
Cited by
Design of polymeric nanoparticles for biomedical delivery applications
Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717
Structure, function, self-assembly, and applications of bottlebrush copolymers
Verduzco, R., Li, X., Pesek, S. L., & Stein, G. E. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00329b · Cited by 676
Designing Smart Polymer Conjugates for Controlled Release of Payloads
Seidi, F., Jenjob, R., & Crespy, D. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00006 · Cited by 316
Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging
Sowers, M. A., McCombs, J. R., Wang, Y., Paletta, J. T., Morton, S. W., Dreaden, E. C., Boska, M. D., Ottaviani, M. F., Hammond, P. T., Rajca, A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6460 · Cited by 279
Self-citationClick chemistry strategies for the accelerated synthesis of functional macromolecules
Geng, Z., Shin, J. J., Xi, Y., & Hawker, C. J. (2021) · Journal of Polymer Science · doi:10.1002/pol.20210126 · Cited by 269
Metadata
- Authors
- Johnson, J. A., Lu, Y. Y., Burts, A. O., Xia, Y., Durrell, A. C., Tirrell, D. A., & Grubbs, R. H.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-12-02
- Volume
- 43
- Issue
- 24
- Pages
- 10326-10335
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2015467604
- Cited by
- 343
- References
- 3
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- green
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