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Temperature and pH Double Responsive Hybrid Cross-Linked Micelles Based on P(NIPAAm-co-MPMA)-b-P(DEA): RAFT Synthesis and “Schizophrenic” Micellization
Abstract
Poly( N -isopropylacrylamide- co -3-(trimethoxysilyl)propyl methacrylate)- b -poly(2-(diethylamino)ethyl methacrylate) (P(NIPAAm- co -MPMA)- b -P(DEA)) copolymer was synthesized by reversible addition−fragmentation chain transfer (RAFT) polymerization. The temperature and pH responsive schizophrenic micellization behaviors of P(NIPAAm- co -MPMA)- b -P(DEA) and the cross-linking of P(NIPAAm- co -MPMA) blocks using inorganic silica-based cross-linking strategy were investigated in detail. Transmission electron microscopy (TEM) showed that the resultant core cross-linked (CCL) and shell cross-linked (SCL) micelles displayed regular spherical shapes with different sizes in N, N ′-dimethylformamide (DMF) and aqueous media. The structure changes of CCL and SCL micelles at different pHs and temperatures were characterized by 1 H NMR. Optical absorption measurements showed that the lower critical solution temperatures (LCSTs) of the CCL and SCL micelles were 37.5 and 40.5 °C, respectively. In vitro drug release study showed that the drug-loaded CCL and SCL micelles displayed thermoresponsive and pH double responsive release behaviors.
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DLS showed its usefulness in defining micelles structural modifications in response to temperature, pH, enzymes, and light.
“Concerning stimuli-responsive micelles, DLS showed its usefulness in defining micelles structural modifications in response to temperature [141][142][143], pH [143,144], enzymes [145,146] and light [141,147].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [142]
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Self-citation
Metadata
- Authors
- Chang, C., Wei, H., Feng, J., Wang, Z.-C., Wu, X.-J., Wu, D.-Q., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X.
- Affiliations
- Wuhan University (CN)
- Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
- Corresponding author
- Zhang, Xian-Zheng
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-06-17
- Volume
- 42
- Issue
- 13
- Pages
- 4838-4844
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2094937805
- Cited by
- 114
- References
- 38
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecules (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- core cross-linked micelles, poly(N-isopropylacrylamide), poly(2-(diethylamino)ethyl methacrylate), RAFT polymerization, pH-responsive micelles, lower critical solution temperature, drug release, stimuli-responsive drug delivery
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