Cited by 114Advanced Polymer Synthesis and CharacterizationHydrogels: synthesis, properties, applicationsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Temperature and pH Double Responsive Hybrid Cross-Linked Micelles Based on P(NIPAAm-co-MPMA)-b-P(DEA): RAFT Synthesis and “Schizophrenic” Micellization

Chang, Cong, Wei, Hua, Feng, Jun, Wang, Zong-Chun, Wu, Xiao-Jun, Wu, De-Qun, Cheng, Si-Xue, Zhang, Xian-Zheng, Zhuo, Ren-Xi·2009·Macromolecules

Abstract

Poly( N -isopropylacrylamide- co -3-(trimethoxysilyl)propyl methacrylate)- b -poly(2-(diethylamino)ethyl methacrylate) (P(NIPAAm- co -MPMA)- b -P(DEA)) copolymer was synthesized by reversible addition−fragmentation chain transfer (RAFT) polymerization. The temperature and pH responsive schizophrenic micellization behaviors of P(NIPAAm- co -MPMA)- b -P(DEA) and the cross-linking of P(NIPAAm- co -MPMA) blocks using inorganic silica-based cross-linking strategy were investigated in detail. Transmission electron microscopy (TEM) showed that the resultant core cross-linked (CCL) and shell cross-linked (SCL) micelles displayed regular spherical shapes with different sizes in N, N ′-dimethylformamide (DMF) and aqueous media. The structure changes of CCL and SCL micelles at different pHs and temperatures were characterized by 1 H NMR. Optical absorption measurements showed that the lower critical solution temperatures (LCSTs) of the CCL and SCL micelles were 37.5 and 40.5 °C, respectively. In vitro drug release study showed that the drug-loaded CCL and SCL micelles displayed thermoresponsive and pH double responsive release behaviors.

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Crossref · 10.1021/ma900492v

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Research works printed but not linked: 2

  1. Xu X., 2008, Macromolecules, 41, 8249
  2. Li Y., 2006, Macromolecules, 39, 81, 10.1021/ma052116r · DOI

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Metadata

Authors
Chang, C., Wei, H., Feng, J., Wang, Z.-C., Wu, X.-J., Wu, D.-Q., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X.
Affiliations
  • Wuhan University (CN)
  • Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
Corresponding author
Zhang, Xian-Zheng
Venue
Macromolecules
Published
2009-06-17
Volume
42
Issue
13
Pages
4838-4844
ISSN
  • 0024-9297 (ISSN-L)
  • 1520-5835
OpenAlex
W2094937805
Cited by
114
References
38
Citations by year
2025: 3 · 2024: 2 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 3 · 2014: 8 · 2013: 10 · 2012: 12
FWCI
7.42
Type
journal article
Language
en
Open access
closed
Locations
Macromolecules (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
core cross-linked micelles, poly(N-isopropylacrylamide), poly(2-(diethylamino)ethyl methacrylate), RAFT polymerization, pH-responsive micelles, lower critical solution temperature, drug release, stimuli-responsive drug delivery

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