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Synthesis and Characterization of Enzymatically-Cross-Linked Poly(ethylene glycol) Hydrogels
Abstract
We demonstrate formation of a hydrogel network by cross-linking functionalized poly(ethylene glycol) (PEG) and a lysine-containing polypeptide through the action of a natural tissue enzyme, transglutaminase. The enzyme reaction rate using a PEG-modified peptide substrate is the same as the reaction rate for free substrate. Both the ratio and total concentration of the two macromers determine whether gelation will occur and the nature of the gel which forms. Under suitable conditions, clear gels form and swell to give a final composition which is 90% water. Diffusion coefficients of small proteins and albumin in the gel are comparable to those in free solution. Gelation proceeds under mild conditions and thus these gels hold potential for forming highly hydrated networks around living cells.
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Cited by
Lutolf, M. P., & Hubbell, J. A. (2003) · Biomacromolecules · doi:10.1021/bm025744e · Cited by 679
A mini review on hydrogels classification and recent developments in miscellaneous applications
Varaprasad, K., Raghavendra, G. M., Jayaramudu, T., Yallapu, M. M., & Sadiku, R. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2017.05.096 · Cited by 534
In situ cell manipulation through enzymatic hydrogel photopatterning
Mosiewicz, K. A., Kolb, L., van der Vlies, A. J., Martino, M. M., Lienemann, P. S., Hubbell, J. A., Ehrbar, M., & Lutolf, M. P. (2013) · Nature Materials · doi:10.1038/nmat3766 · Cited by 308
Lee, F., Chung, J. E., & Kurisawa, M. (2008) · Soft Matter · doi:10.1039/b719557e · Cited by 300
Hydrogels for Musculoskeletal Tissue Engineering
Varghese, S., & Elisseeff, J. H. (2006) · Advances in Polymer Science · doi:10.1007/12_072 · Cited by 173
Fu, P.-S., Wang, J.-C., Lai, P.-L., Liu, S.-M., Chen, Y.-S., Chen, W.-C., & Hung, C.-C. (2021) · Polymers · doi:10.3390/polym13060938 · Cited by 25
Metadata
- Authors
- Sperinde, J. J., & Griffith, L. G.
- Venue
- Macromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-09-01
- Volume
- 30
- Issue
- 18
- Pages
- 5255-5264
- ISSN
- 0024-9297 (ISSN-L)
- 1520-5835
- OpenAlex
- W2040011847
- Cited by
- 212
- References
- 0
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- closed
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