The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Dendrimers as Drugs: Discovery and Preclinical and Clinical Development of Dendrimer-Based Microbicides for HIV and STI Prevention
Abstract
Starpharma focuses on the use of dendrimers as drugs in their own right, in contrast to dendrimers as drug delivery vehicles or diagnostics. This contextual review describes how dendrimers offer a unique platform for exploring chemical diversity on the nanoscale and how the production of dendrimer libraries covering a diverse array of macromolecular structures can be used in drug discovery and development. Using Starpharma's work on the prevention of HIV and sexually transmitted infections (STIs) through the development of microbicide candidates as an example, the process from which SPL7013 emerged as a development candidate is described. Following a range of preclinical studies, Starpharma submitted an investigational new drug application (IND) for SPL7013 gel (VivaGel) to the United States Food and Drug Administration (FDA) in June 2003, the first such submission for a dendrimer-based drug. The first clinical trial under this IND was completed in 2004.
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Fast and Convenient Divergent Synthesis of Aliphatic Ester Dendrimers by Anhydride Coupling
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Self-citationDendrimer-based Macromolecular MRI Contrast Agents: Characteristics and Application
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Polymer–drug conjugate therapeutics: advances, insights and prospects
Ekladious, I., Colson, Y. L., & Grinstaff, M. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0005-0 · Cited by 855
Clinical Translation of Nanomedicine
Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00116 · Cited by 772
Khandel, P., Yadaw, R. K., Soni, D. K., Kanwar, L., & Shahi, S. K. (2018) · Journal of Nanostructure in Chemistry · doi:10.1007/s40097-018-0267-4 · Cited by 452
New Modalities for Challenging Targets in Drug Discovery
Valeur, E., Guéret, S. M., Adihou, H., Gopalakrishnan, R., Lemurell, M., Waldmann, H., Grossmann, T. N., & Plowright, A. T. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201611914 · Cited by 382
Nanoparticle Technologies for Cancer Therapy
Alexis, F., Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2010) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-00477-3_2 · Cited by 364
Biodegradable, polymeric nanoparticle delivery systems for cancer therapy
Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2007) · Nanomedicine · doi:10.2217/17435889.2.5.669 · Cited by 249
Drug delivery using multifunctional dendrimers and hyperbranched polymers
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2010.534981 · Cited by 156
Metadata
- Authors
- McCarthy, T. D., Karellas, P., Henderson, S. A., Giannis, M., O'Keefe, D. F., Heery, G., Paull, J. R. A., Matthews, B. R., & Holan, G.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-06-22
- Volume
- 2
- Issue
- 4
- Pages
- 312-318
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2019120007
- Cited by
- 314
- References
- 19
- FWCI
- 18.90
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
