Cited by 156Dendrimers and Hyperbranched PolymersNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Drug delivery using multifunctional dendrimers and hyperbranched polymers

Paleos, Constantinos M, Tsiourvas, Dimitris, Sideratou, Zili, Tziveleka, Leto-Aikaterini·2010·Expert Opinion on Drug Delivery

Abstract

IMPORTANCE OF THE FIELD: The review presents the design strategy and synthesis of multifunctional dendrimers and hyperbranched polymers with the objective to develop effective drug delivery systems. AREAS COVERED IN THIS REVIEW: Well-characterized, commercially available dendritic polymers were subjected to functionalization for preparing drug delivery systems of low toxicity, high loading capacity, ability to target specific cells and transport through their membranes. This has been achieved by surface targeting ligands, which render the carriers specific to certain cells and polyethylene glycol groups, securing water solubility, stability and prolonged circulation. Moreover, transport agents facilitate transport through cell membranes while fluorescent probes detect their intracellular localization. A common feature of surface groups is multivalency, which considerably enhances their binding strength with complementary cell receptors. To these properties, one should also add the property of attaining high loading of active ingredients coupled with controlled and/or triggered release. WHAT THE READER WILL GAIN: Readers will be exposed to the strategy of synthesizing multifunctional polymers, aimed at the development of effective drug delivery systems. TAKE HOME MESSAGE: Multifunctional systems upgrade the therapeutic potential of drugs and, in certain cases, may even lead to the application of new bioactive compounds that would otherwise not be feasible.

Integrity signals

Registry

Crossref · 10.1517/17425247.2010.534981

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Liposomes application and lipid-based drug delivery systems have been narrowed due to attained drug resistance and poor targeting.

    “Nevertheless, liposomes application and lipid-based drug delivery systems have been narrowed due to attained drug resistance and poor targeting [98,99].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [99]

Cites

Flagged first, then by citations

1 of the 113 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Paleos, C. M., Tsiourvas, D., Sideratou, Z., & Tziveleka, L.-A.
Affiliations
National Centre of Scientific Research "Demokritos" (GR)
Venue
Expert Opinion on Drug Delivery
Published
2010-11-17
Volume
7
Issue
12
Pages
1387-1398
ISSN
  • 1742-5247 (ISSN-L)
  • 1744-7593
OpenAlex
W2075479570
Cited by
156
References
113
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 6 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 11 · 2014: 12 · 2013: 19 · 2012: 14
FWCI
11.37
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Delivery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
dendrimers, hyperbranched polymers, drug delivery systems, surface functionalization, targeting ligands, polyethylene glycol, multivalency, cell membrane transport, fluorescent probes, controlled release, triggered release, drug loading capacity, polymer synthesis
MeSH terms
Animals, Drug Carriers, Humans, Polymers, Solubility, Drug Design, Gene Transfer Techniques, Dendrimers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review