Efficient Simultaneous Tumor Targeting Delivery of All-Trans Retinoid Acid and Paclitaxel Based on Hyaluronic Acid-Based Multifunctional Nanocarrier
Abstract
An amphiphilic hyaluronic acid (HA)-g-all-trans retinoid acid (HRA) conjugate was successfully developed as a tumor-targeting nanocarrier for potentially synergistic combination chemotherapy of all-trans retinoid acid (ATRA) and paclitaxel (PTX). The HRA conjugate was synthesized by an imine reaction between HA-COOH and ATRA-NH2. PTX-loaded HRA nanoparticles possessed a high loading capacity, nanoscale particle sizes, and good biocompatible characteristics. Cell viability assays indicated that PTX-loaded HRA nanoparticles exhibited concentration- and time-dependent cytotoxicity. Moreover, they displayed obvious superiority in inducing the apoptosis of tumor cells. Cellular uptake analysis suggested that HRA nanoparticles could be efficiently taken up by cells via endocytic pathway and transport into the nucleus, contributing to HA receptor-mediated endocytosis and ATRA-induced nuclear translocation, respectively. Moreover, in vivo imaging analysis indicated that the accumulation of DiR-loaded HRA nanoparticles in tumor was increased obviously after intravenous administration as compared to free DiR solution, which confirmed that the HRA nanoparticles could assist the drugs targeting to the tumor. Furthermore, PTX-loaded HRA nanoparticles exhibited greater tumor growth inhibition effect in vivo with reducing the toxicity. Therefore, HRA nanoparticles can be considered as a promising targeted codelivery system for combination cancer chemotherapy.
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Some progress has been made in the last 5 years regarding formulations with the ability to release RA in combination with other agents.
“Although some progress has been made in the last 5 years regarding formulations with the ability to release RA in combination with other agents54,112”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [54]
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- Authors
- Yao, J., Zhang, L., Zhou, J., Liu, H., & Zhang, Q.
- Affiliations
- China Pharmaceutical University (CN)
- Peking University (CN)
- Corresponding author
- Yao, Jing
- Zhou, Jianping
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-01-31
- Volume
- 10
- Issue
- 3
- Pages
- 1080-1091
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2145962904
- Cited by
- 87
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 17 · 2014: 12 · 2013: 4
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- hyaluronic acid, all-trans retinoic acid, paclitaxel, anticancer drug delivery, multifunctional nanocarriers, combination chemotherapy, nanoparticle drug loading, apoptosis, tumor accumulation, tumor growth inhibition, cytotoxicity
- MeSH terms
- Animals, Cells, Cultured, Drug Carriers, Female, Flow Cytometry, Hemolysis, Humans, Hyaluronic Acid, Melanoma, Experimental, Mice, Inbred BALB C, Rabbits, Tretinoin, Apoptosis, Paclitaxel, Mice, Nanoparticles, Hep G2 Cells
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