Cited by 125Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers

Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery

Wu, Jinhui, Song, Chenchen, Jiang, Chenxiao, Shen, Xin, Qiao, Qian, Hu, Yiqiao·2013·Molecular Pharmaceutics

Abstract

Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers' attentions. To improve the antitumor efficacy, we developed a nucleolin targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used as drug carrier and a DNA aptamer named AS1411, which had high affinity to nucleolin, was used as a bullet. The HSA nanoparticles (NPs-PTX) were fabricated by a novel self-assembly method and then modified with AS1411 (Apt-NPs-PTX). The resulted Apt-NPs-PTX were spherical. Compared with NPs-PTX, the uptake of Apt-NPs-PTX displayed a significant increase in MCF-7 cells while there was a decrease in nontumor cell lines such as MCF-10A and 3T3 cells. In a cytotoxic study, Apt-NPs-PTX displayed an enhanced cytotoxicity in MCF-7 tumor cells while there was almost no cytotoxicity in MCF-10A cells. Endostatin, a nucleolin inhibitor, could significantly decrease the internalization of Apt-NPs-PTX, suggesting nucleolin mediates the transmembrane process of Apt-NPs-PTX. Therefore, the AS1411 modified NTPN delivery system might be a promising targeted drug delivery system.

Integrity signals

Registry

Crossref · 10.1021/mp300686g

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Wu, J., Song, C., Jiang, C., Shen, X., Qiao, Q., & Hu, Y.
Affiliations
State Key Laboratory of Pharmaceutical Biotechnology (CN)
Corresponding author
  • Wu, Jinhui
  • Hu, Yiqiao
Venue
Molecular Pharmaceutics
Published
2013-08-28
Volume
10
Issue
10
Pages
3555-3563
ISSN
  • 1543-8384 (ISSN-L)
  • 1543-8392
OpenAlex
W2004023680
Cited by
125
References
32
Citations by year
2026: 5 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 14 · 2020: 16 · 2019: 10 · 2018: 13 · 2017: 15 · 2016: 12 · 2015: 14 · 2014: 5 · 2012: 1
FWCI
3.94
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
nucleolin, protein nanoparticles, human serum albumin, targeted drug delivery, paclitaxel, MCF-7 cells, endostatin, nanoparticle uptake, self-assembly, tumor targeting
MeSH terms
Nucleolin, Animals, Antineoplastic Agents, Cell Line, Cell Membrane, Cell Survival, Humans, Phosphoproteins, 3T3 Cells, RNA-Binding Proteins, Paclitaxel, Endostatins, Mice, Nanoparticles, MCF-7 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review