Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery
Abstract
Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers' attentions. To improve the antitumor efficacy, we developed a nucleolin targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used as drug carrier and a DNA aptamer named AS1411, which had high affinity to nucleolin, was used as a bullet. The HSA nanoparticles (NPs-PTX) were fabricated by a novel self-assembly method and then modified with AS1411 (Apt-NPs-PTX). The resulted Apt-NPs-PTX were spherical. Compared with NPs-PTX, the uptake of Apt-NPs-PTX displayed a significant increase in MCF-7 cells while there was a decrease in nontumor cell lines such as MCF-10A and 3T3 cells. In a cytotoxic study, Apt-NPs-PTX displayed an enhanced cytotoxicity in MCF-7 tumor cells while there was almost no cytotoxicity in MCF-10A cells. Endostatin, a nucleolin inhibitor, could significantly decrease the internalization of Apt-NPs-PTX, suggesting nucleolin mediates the transmembrane process of Apt-NPs-PTX. Therefore, the AS1411 modified NTPN delivery system might be a promising targeted drug delivery system.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AS1411 possesses a specific interaction with nucleolin, an important biomarker in various cancer cells that promotes tumor growth and metastasis.
“Recently, AS1411 was reported to possess a specific interaction with nucleolin, an important biomarker in various cancer cells to promote the tumor growth and metastasis.48,49”
Cites
Effect of Surface Properties on Nanoparticle–Cell Interactions
Verma, A., & Stellacci, F. (2009) · Small · doi:10.1002/smll.200901158 · Cited by 2,621 · see citing works
Taxol stabilizes microtubules in mouse fibroblast cells.
Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971 · see citing works
[11] Calculation of protein conformation from circular dichroism
Yang, J. T., Wu, C. C., & Martínez, H. M. (1986) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(86)30013-2 · Cited by 1,644 · see citing works
Albumin-based nanoparticles as potential controlled release drug delivery systems
Elzoghby, A. O., Samy, W. M., & Elgindy, N. A. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.031 · Cited by 1,526 · see citing works
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101 · see citing works
Taxol: A Novel Investigational Antimicrotubule Agent
Rowinsky, E. K., Cazenave, L. A., & Donehower, R. C. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.15.1247 · Cited by 1,096 · see citing works
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer
Bates, P. J., Laber, D. A., Miller, D. M., Thomas, S. D., & Trent, J. O. (2009) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2009.01.004 · Cited by 874 · see citing works
Protein nanoparticles as drug carriers in clinical medicine
Hawkins, M. J., Soon-Shiong, P., & Desai, N. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.044 · Cited by 779 · see citing works
Aptamer-functionalized PEG–PLGA nanoparticles for enhanced anti-glioma drug delivery
Guo, J., Gao, X., Su, L., Xia, H., Gu, G., Pang, Z., Jiang, X., Yao, L., Chen, J., & Chen, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.004 · Cited by 567 · see citing works
Sheddable Coatings for Long-Circulating Nanoparticles
Romberg, B., Hennink, W. E., & Storm, G. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9348-7 · Cited by 554 · see citing works
Gianni, L., Kearns, C. M., Giani, A., Capri, G., Viganò, L., Lacatelli, A., Bonadonna, G., & Egorin, M. J. (1995) · Journal of Clinical Oncology · doi:10.1200/jco.1995.13.1.180 · Cited by 553 · see citing works
Molecular dissection of nucleolin's role in growth and cell proliferation: new insights
Srivastava, M., & Pollard, H. B. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.14.1911 · Cited by 495 · see citing works
Discovery and development of anticancer aptamers
Ireson, C. R., & Kèlland, L. R. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0172 · Cited by 481 · see citing works
Fang, C., Shi, B., Pei, Y., Hong, M., Wu, J., & Chen, H. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.002 · Cited by 424 · see citing works
Self-citationAntiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding
Bates, P. J., Kahlon, J. B., Thomas, S. D., Trent, J. O., & Miller, D. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26369 · Cited by 407 · see citing works
Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes
Cao, Z. C., Tong, R., Mishra, A., Xu, W., Wong, G. C. L., Cheng, J., & Lu, Y. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901452 · Cited by 372 · see citing works
Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin
Shi, H., Huang, Y., Zhou, H., Song, X., Yuan, S., Fu, Y., & Luo, Y. (2007) · Blood · doi:10.1182/blood-2007-01-064428 · Cited by 257 · see citing works
The Cell-Surface-Expressed Nucleolin Is Associated with the Actin Cytoskeleton
Hovanessian, A. G., Puvion-dutilleul, F., Nisole, S., Svab, J., Perret, E., Deng, J., & Krust, B. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.5071 · Cited by 244 · see citing works
Inhibition of DNA Replication and Induction of S Phase Cell Cycle Arrest by G-rich Oligonucleotides
Xu, X., Hamhouyia, F., Thomas, S. D., Burke, T. J., Girvan, A. C., McGregor, W. G., Trent, J. O., Miller, D. M., & Bates, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104446200 · Cited by 167 · see citing works
Development of aptamer therapeutics
Bunka, D. H. J., Platonova, O., & Stockley, P. G. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.06.009 · Cited by 152 · see citing works
Évora, C., Soriano, I., Rogers, R. A., Shakesheff, K. M., Hanes, J. S., & Langer, R. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00149-1 · Cited by 147 · see citing works
Đapić, V., Bates, P. J., Trent, J. O., Rodger, A., Thomas, S. D., & Miller, D. M. (2002) · Biochemistry · doi:10.1021/bi0119520 · Cited by 140 · see citing works
Janssens, S., Zeure, A. D., Paudel, A., Humbeeck, J. V., Rombaut, P., & den Mooter, G. V. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0069-y · Cited by 126 · see citing works
Masuya, D., Huang, C., Liu, D., Kameyama, K., Hayashi, E., Yamauchi, A., Kobayashi, S., Haba, R., & Yokomise, H. (2001) · Cancer · doi:10.1002/1097-0142(20011115)92:10 · Cited by 122 · see citing works
Paclitaxel in Cancer Treatment: Perspectives and Prospects of its Delivery Challenges
Singh, S., & Dash, A. K. (2009) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v26.i4.10 · Cited by 102 · see citing works
Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals
Orava, E. W., Cicmil, N., & Gariépy, J. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.02.004 · Cited by 89 · see citing works
Aptamer Applications for Targeted Cancer Therapy
Barbas, A. S., Mi, J., Clary, B. M., & White, R. R. (2010) · Future Oncology · doi:10.2217/fon.10.67 · Cited by 88 · see citing works
Gong, G., Xu, Y., Zhou, Y., Meng, Z., Ren, G., Zhao, Y., Zhang, X., Wu, J., & Hu, Y. (2011) · Biomacromolecules · doi:10.1021/bm201401s · Cited by 76 · see citing works
Self-citationXue, Z., Shan, X., Lapeyre, B., & Mélèse, T. (1993) · PubMed · Cited by 49 · see citing works
Liu, X., Lei, L., Hou, J., Tang, M.-F., Guo, S., Wang, Z., & Chen, K. (2011) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-010-4213-3 · Cited by 47 · see citing works
Phase I trial of cremophor EL with bolus doxorubicin.
Millward, M., Webster, L., Rischin, D., Stokes, K. H., Toner, G. C., Bishop, J. F., Olver, I., Linahan, B. Μ., Linsenmeyer, M. E., & Woodcock, D. M. (1998) · PubMed · Cited by 37 · see citing works
Enhanced antitumor efficacy of cisplatin by tirapazamine–transferrin conjugate
Wu, L., Wu, J., Zhou, Y., Tang, X., Du, Y., & Hu, Y. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.04.032 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Sheng, Z., Hu, D., Zheng, M., Zhao, P., Liu, H., Gao, D., Gong, P., Gao, G., Zhang, P., Ma, Y., et al. (2014) · ACS Nano · doi:10.1021/nn5062386 · Cited by 719 · see citing works
Nimjee, S. M., White, R. R., Becker, R. C., & Sullenger, B. A. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104558 · Cited by 616 · see citing works
Breast Cancer: Conventional Diagnosis and Treatment Modalities and Recent Patents and Technologies
Nounou, M. I., ElAmrawy, F., Ahmed, N., Abdelraouf, K., Goda, S., & Qhattal, H. S. S. (2015) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s29420 · Cited by 374 · see citing works
Li, L., Hou, J., Liu, X., Guo, Y., Wu, Y., Zhang, L., & Yang, Z. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.019 · Cited by 286 · see citing works
Li, F., Lu, J. G., Liu, J., Liang, C., Wang, M., Wang, L., Li, D., Yao, H., Zhang, Q., Wen, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01565-6 · Cited by 280 · see citing works
RetractedJiang, C., Cheng, H., Yuan, A., Tang, X., Wu, J., & Hu, Y. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.11.041 · Cited by 256 · see citing works
Self-citationCapture-SELEX for aptamer selection: A short review
Lyu, C., Khan, I. M., & Wang, Z. (2021) · Talanta · doi:10.1016/j.talanta.2021.122274 · Cited by 254 · see citing works
Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing
Ku, T., Zhang, T., Luo, H., Yen, T., Chen, P., Han, Y., & Lo, Y. (2015) · Sensors · doi:10.3390/s150716281 · Cited by 242 · see citing works
Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy
Zhou, J., & Rossi, J. J. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.21 · Cited by 234 · see citing works
Liu, J., Wei, T., Zhao, J., Huang, Y., Deng, H., Kumar, A., Wang, C., Liang, Z., Ma, X., & Liang, X. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.013 · Cited by 208 · see citing works
Aptamers and Their Applications in Nanomedicine
Sun, H., & Zu, Y. (2015) · Small · doi:10.1002/smll.201403073 · Cited by 181 · see citing works
Li, Z., Wang, Y., Shen, Y., Qian, C., Oupický, D., & Sun, M. (2020) · Science Advances · doi:10.1126/sciadv.aaz9240 · Cited by 171 · see citing works
Taghavi, S., Nia, A. H., Abnous, K., & Ramezani, M. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.11.027 · Cited by 152 · see citing works
Translatable High Drug Loading Drug Delivery Systems Based on Biocompatible Polymer Nanocarriers
Chen, W., Zhou, S., Ge, L., Wu, W., & Jiang, X. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00218 · Cited by 144 · see citing works
Impact of albumin based approaches in nanomedicine: Imaging, targeting and drug delivery.
Bhushan, B., Khanadeev, V., Khlebtsov, B., Khlebtsov, N., & Gopinath, P. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.06.012 · Cited by 112 · see citing works
Lale, S. V., Girija, A. R., Aravind, A., Kumar, D. S., & Koul, V. (2014) · Biomacromolecules · doi:10.1021/bm5001263 · Cited by 125 · see citing works
Zhao, J., Liu, P., Ma, J., Li, D., Yang, H., Chen, W., & Jiang, Y. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s224160 · Cited by 120 · see citing works
Aptamers as an approach to targeted cancer therapy
Mahmoudian, F., Ahmari, A., Shabani, S., Sadeghi, B., Fahimirad, S., & Fattahi, F. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03295-4 · Cited by 124 · see citing works
AS1411-conjugated gold nanospheres and their potential for breast cancer therapy
Malik, M. T., O’Toole, M. G., Casson, L. K., Thomas, S. D., Bardi, G. T., Reyes‐Reyes, E. M., Ng, C. K., Kang, K. A., & Bates, P. J. (2015) · Oncotarget · doi:10.18632/oncotarget.4207 · Cited by 116 · see citing works
Ren, H., Liu, J., Su, F., Ge, S., Yuan, A., Dai, W., Wu, J., & Hu, Y. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b14885 · Cited by 112 · see citing works
Self-citationAnti-nucleolin aptamer AS1411: an advancing therapeutic
den Avont, A. V., & Sharma-Walia, N. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1217769 · Cited by 112 · see citing works
Zhu, X., Zhou, H., Liu, Y., Wen, Y., Wei, C., Yu, Q., & Liu, J. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.10.012 · Cited by 104 · see citing works
Romano, S., Fonseca, N. A., Simões, S., Gonçalves, J., & Moreira, J. N. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.06.018 · Cited by 104 · see citing works
Advances in aptamer-mediated targeted delivery system for cancer treatment
He, S., Du, Y., Tao, H., & Duan, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124173 · Cited by 99 · see citing works
Ghahremani, F. H., Shahbazi‐Gahrouei, D., Kefayat, A., Motaghi, H., Mehrgardi, M. A., & Javanmard, S. H. (2018) · RSC Advances · doi:10.1039/c7ra11116a · Cited by 96 · see citing works
Raţă, D. M., Cadinoiu, A. N., Atanase, L. I., Popa, M., Mihai, C. T., Solcan, C., Ochiuz, L., & Vochița, G. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111591 · Cited by 92 · see citing works
Lin, Z., Goswami, N., Xue, T., Chai, O. J. H., Xu, H., Liu, Y., Su, Y., & Xie, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202105662 · Cited by 89 · see citing works
Luo, Z., Yan, Z., Jin, K., Pang, Q., Jiang, T., Lu, H., Liu, X., Pang, Z., Yu, L., & Jiang, X. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2016.12.004 · Cited by 87 · see citing works
Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer
Park, J. Y., Cho, Y. L., Chae, J. R., Moon, S. H., Cho, W. G., Choi, Y. J., Lee, S., & Kang, W. J. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.06.003 · Cited by 87 · see citing works
Zhang, Y., Song, T., Feng, T., Wan, Y., Blum, N. T., Liu, C., Zheng, C., Zhao, Z., Jiang, T., Wang, J., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100987 · Cited by 80 · see citing works
Human anti-nucleolin recombinant immunoagent for cancer therapy
Palmieri, D., Richmond, T. K., Piovan, C., Sheetz, T. J., Zanesi, N. A. O., Troise, F., James, C. L., Wernicke, D., Nyei, F., Gordon, T. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507087112 · Cited by 80 · see citing works
Zhang, J., Chen, R., Fang, X., Chen, F., Wang, Y., & Chen, M. (2015) · Nano Research · doi:10.1007/s12274-014-0619-4 · Cited by 78 · see citing works
Yu, K., Hai, X., Yue, S., Song, W., & Bi, S. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.129535 · Cited by 76 · see citing works
Aptamer-functionalized albumin-based nanoparticles for targeted drug delivery
Xu, L., He, X., Liu, B., Xu, C., Ai, S., Zhuo, R., & Cheng, S. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.07.008 · Cited by 73 · see citing works
Recent Advances on the Development of Pharmacotherapeutic Agents on the Basis of Human Serum Albumin
Liu, F., Mu, J., & Xing, B. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150302115411 · Cited by 70 · see citing works
Ghahremani, F., Kefayat, A., Shahbazi-Gahrouei, D., Motaghi, H., Mehrgardi, M. A., & Haghjooy-Javanmard, S. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0180 · Cited by 70 · see citing works
Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery
Cai, Y., Xu, Z., Shuai, Q., Zhu, F., Xu, J. H., Gao, X., & Sun, X. (2020) · Biomaterials Science · doi:10.1039/c9bm02036e · Cited by 69 · see citing works
Yang, S.-D., Ren, Z., Chen, M., Wang, Y., You, B., Chen, W., Qu, C., Liu, Y., & Zhang, X. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b01093 · Cited by 66 · see citing works
Lale, S. V., Kumar, A., Naz, F., Bharti, A. C., & Koul, V. (2015) · Polymer Chemistry · doi:10.1039/c4py01698j · Cited by 64 · see citing works
Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy
Ma, Y., Yu, S., Ni, S., Zhang, B., Kung, A. C. F., Gao, J., Lü, A., & Zhang, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.626910 · Cited by 64 · see citing works
Applications of aptamers for chemistry analysis, medicine and food security
Huang, R., Xi, Z., & He, N. (2015) · Science China Chemistry · doi:10.1007/s11426-015-5344-7 · Cited by 62 · see citing works
Aptamers as smart ligands for nano-carriers targeting
Mokhtarzadeh, A., Tabarzad, M., Ranjbari, J., de la Guárdia, M., Hejazi, M., & Ramezani, M. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2016.06.018 · Cited by 60 · see citing works
Hassanin, I. A., & Elzoghby, A. O. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1813713 · Cited by 56 · see citing works
Battogtokh, G., Kang, J. H., & Ko, Y. T. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.07.013 · Cited by 54 · see citing works
Nucleolin‑based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review)
Thongchot, S., Aksonnam, K., Thuwajit, P., Yenchitsomanus, P., & Thuwajit, C. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5284 · Cited by 53 · see citing works
Self‐Assembled Aptamer‐Nanomedicine for Targeted Chemotherapy and Gene Therapy
Zhao, N., Zeng, Z., & Zu, Y. (2017) · Small · doi:10.1002/smll.201702103 · Cited by 53 · see citing works
T1–T2 molecular magnetic resonance imaging of renal carcinoma cells based on nano-contrast agents
Li, J., You, J., Wu, C., Dai, Y., Shi, M., Dong, L., & Xu, K. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s168660 · Cited by 52 · see citing works
DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors
Shishparenok, A. N., Furman, V. V., & Zhdanov, D. D. (2023) · Cancers · doi:10.3390/cancers15072151 · Cited by 50 · see citing works
Battogtokh, G., & Ko, Y. T. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.10.014 · Cited by 47 · see citing works
A two-component active targeting theranostic agent based on graphene quantum dots
Wang, X., Sun, X., He, H., Yang, H., Lao, J., Song, Y., Xia, Y., Xu, H., Zhang, X., & Huang, F. L. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00211g · Cited by 46 · see citing works
Kang, J. H., & Ko, Y. T. (2019) · Biomaterials Science · doi:10.1039/c9bm00403c · Cited by 46 · see citing works
Wei, Z., Yu, Y., Hu, S., Yi, X., & Wang, J. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c21109 · Cited by 45 · see citing works
Dobrovolskaia, M. A., & McNeil, S. E. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1042857 · Cited by 44 · see citing works
Meeting the needs of breast cancer: A nucleolin’s perspective
Gregório, A. C., Lacerda, M., Figueiredo, P., Simões, S., Dias, S., & Moreira, J. N. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.03.008 · Cited by 44 · see citing works
Liang, X., Wang, Y., Shi, H., Dong, M., Han, H., & Li, Q. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s304526 · Cited by 41 · see citing works
The influencing factors and functions of DNA G‐quadruplexes
Yuan, W.-F., Wan, L.-Y., Peng, H., Zhong, Y., Cai, W.-L., Zhang, Y.-Q., Ai, W.-B., & Wu, J.-F. (2020) · Cell Biochemistry and Function · doi:10.1002/cbf.3505 · Cited by 32 · see citing works
Self-citationA novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy
Zhao, Y., Chen, G., Meng, Z., Gong, G., Zhao, W., Wang, K., & Liu, T. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1639846 · Cited by 40 · see citing works
Aptamer-Based In Vivo Therapeutic Targeting of Glioblastoma
Cesarini, V., Scopa, C., Silvestris, D. A., Scafidi, A., Petrera, V., Baldo, G. D., & Gallo, A. (2020) · Molecules · doi:10.3390/molecules25184267 · Cited by 39 · see citing works
Sun, Y., Wang, Y., Liu, Y., Weng, B., Yang, H., Xiang, Z., Ran, J., Wang, H., & Yang, C. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c17642 · Cited by 39 · see citing works
Nehate, C., Raynold, A. A. M., & Koul, V. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b11716 · Cited by 38 · see citing works
Fabrication of aptamer modified TiO2 nanofibers for specific capture of circulating tumor cells
Liu, H., Sun, N., Ding, P., Chen, C., Wu, Z., Zhu, W., Liu, L., Wang, Z., & Pei, R. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110985 · Cited by 38 · see citing works
Wang, X., Gao, W., Fan, H., Ding, D., Lai, X.-F., Zou, Y., Chen, L., Chen, Z., & Tan, W. (2016) · Nanoscale · doi:10.1039/c6nr00369a · Cited by 32 · see citing works
Nehate, C., Raynold, A. A. M., Haridas, V., & Koul, V. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00178 · Cited by 32 · see citing works
Sun, X., Liu, B., Chen, X., Lin, H., Peng, Y., Li, Y., Zheng, H., Xu, Y., Ou, X., Yan, S., et al. (2019) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-019-6278-y · Cited by 32 · see citing works
Xiong, H., Yan, J., Cai, S., He, Q., Wen, N., Wang, Y., Hu, Y., Peng, D., Liu, Y., & Liu, Z. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00335 · Cited by 32 · see citing works
Self-citationNehate, C., Alex, M. R. A., Kumar, A., & Koul, V. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.024 · Cited by 29 · see citing works
Wang, K., Yuan, A., Yu, J., Wu, J., & Hu, Y. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2015.12.007 · Cited by 27 · see citing works
Self-citationGou, Y., Zhang, Y., Zhang, Z., Wang, J., Zhou, Z., Liang, H., & Yang, F. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b01074 · Cited by 27 · see citing works
Self-assembly of an aptamer-decorated chimeric peptide nanocarrier for targeted cancer gene delivery
Dehghani, S., Alibolandi, M., Amiri‐Tehranizadeh, Z., Oskuee, R. K., Nosrati, R., Soltani, F., & Ramezani, M. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112047 · Cited by 27 · see citing works
Han, S. Y., Sun, R., Su, H. H., Lv, J., Xu, H., Zhang, D., & Fu, Y. (2018) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2018.07.005 · Cited by 26 · see citing works
Mie, M., Matsumoto, R., Mashimo, Y., Cass, A. E. G., & Kobatake, E. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4467-2 · Cited by 26 · see citing works
He, L., Zeng, L., Mai, X., Shi, C., Luo, L., & Chen, T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c6tb03365b · Cited by 25 · see citing works
Aptamer-mediated selective delivery of a cytotoxic cationic NHC-Au( i ) complex to cancer cells
Niu, W., Teng, I., Chen, X., Tan, W., & Veige, A. S. (2017) · Dalton Transactions · doi:10.1039/c7dt02616a · Cited by 25 · see citing works
Cao, Y., Yang, Y., Feng, S., & Wan, Y. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103698 · Cited by 24 · see citing works
Nucleolin-Targeting AS1411 Aptamer-Conjugated Nanospheres for Targeted Treatment of Glioblastoma
Seo, K., Hwang, K., Nam, K. M., Kim, M. J., Shin, S., SONG, Y.-K., & Kim, C. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040566 · Cited by 24 · see citing works
Organic additives stabilize RNA aptamer binding of malachite green
Zhou, Y., Chi, H., Wu, Y., Marks, R. S., & Steele, T. W. J. (2016) · Talanta · doi:10.1016/j.talanta.2016.06.067 · Cited by 23 · see citing works
Novel Complex of PD-L1 Aptamer and Holliday Junction Enhances Antitumor Efficacy in Vivo
Li, T., Yao, F., An, Y., Li, X., Duan, J., & Yang, X. (2021) · Molecules · doi:10.3390/molecules26041067 · Cited by 23 · see citing works
Chen, R., Sun, P., Chu, X., Pu, X., Yang, Y., Zhang, N., & Zhao, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s225142 · Cited by 23 · see citing works
Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets
Murphy, E. M., Centner, C. S., Bates, P. J., Malik, M. T., & Kopechek, J. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233466 · Cited by 23 · see citing works
Zhang, R., Wang, S.-B., Wu, W.-G., Kankala, R. K., Chen, A.-Z., Liu, Y.-G., & Fan, J.-Q. (2017) · Journal of Nanoparticle Research · doi:10.1007/s11051-017-3913-8 · Cited by 22 · see citing works
DNA Walker‐Regulated Cancer Cell Growth Inhibition
Li, F., Cha, T., Pan, J., Özçelikkale, A., Han, B., & Choi, J. H. (2016) · ChemBioChem · doi:10.1002/cbic.201600052 · Cited by 22 · see citing works
Folic acid-modified fluorescent dye-protein nanoparticles for the targeted tumor cell imaging
Xu, L., Jiang, G., Chen, H., Zan, Y., Hong, S., Zhang, T., Zhang, Y., & Pei, R. (2018) · Talanta · doi:10.1016/j.talanta.2018.10.094 · Cited by 21 · see citing works
Dynamics of delivering aptamer targeted nano-drugs into cells
Liu, Y., Yang, Y., Zhang, Q., Lu, D., Li, S., Li, J., Yang, G., & Shan, Y. (2021) · Journal of Materials Chemistry B · doi:10.1039/d0tb02527e · Cited by 21 · see citing works
Hybrid Cell-Penetrating Foldamer with Superior Intracellular Delivery Properties and Serum Stability
Douat, C., Bornerie, M., Antunes, S., Guichard, G., & Kichler, A. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00075 · Cited by 20 · see citing works
Targeting Host Cell Surface Nucleolin for RSV Therapy: Challenges and Opportunities
Mastrangelo, P., Norris, M. J., Duan, W., Barrett, E. G., Moraes, T. J., & Hegele, R. G. (2017) · Vaccines · doi:10.3390/vaccines5030027 · Cited by 19 · see citing works
Naz, F., Dinda, A. K., Kumar, A., & Koul, V. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118561 · Cited by 19 · see citing works
Novel nanosized AS1411–chitosan–BODIPY conjugate for molecular fluorescent imaging
Taki, S., & Ardestani, M. S. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s202561 · Cited by 18 · see citing works
Shim, G., Park, J.-W., Kim, M., Yang, G., Lee, Y. J., & Oh, Y. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102053 · Cited by 18 · see citing works
AS1411-functionalized delivery nanosystems for targeted cancer therapy
Kozani, P. S., Kozani, P. S., & Malik, M. T. (2021) · Exploration of Medicine · doi:10.37349/emed.2021.00039 · Cited by 18 · see citing works
Gandhi, S., Sethuraman, S., & Krishnan, U. M. (2012) · Dalton Transactions · doi:10.1039/c2dt30853c · Cited by 17 · see citing works
Zakharova, L. Y., Pashirova, T. N., Kashapov, R. R., Gabdrakhmanov, D. R., & Sinyashin, O. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46143-6.00024-5 · Cited by 17 · see citing works
AS1411 aptamer based nanomaterials: A novel approach for breast cancer therapy
Verma, Y., Khan, I., Dongsar, T. T., Alsayari, A., Wahab, S., Sahebkar, A., & Kesharwani, P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.145125 · Cited by 16 · see citing works
Saidi, D., Obeidat, M., Alsotari, S. T., Ibrahim, A. A., Albuqain, R., Wehaibi, S., Alqudah, D. A., Nsairat, H., Alshaer, W., & Alkilany, A. M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30743 · Cited by 16 · see citing works
Advances in nanoparticle mediated targeting of RNA binding protein for cancer
Kashikar, R., Kotha, A. K., Shah, S., Famta, P., Singh, S. B., Srivastava, S., & Chougule, M. B. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114257 · Cited by 16 · see citing works
Sharma, G., Jagtap, J. M. M., Parchur, A. K., Gogineni, V. R., Ran, S., Bergom, C. R., White, S. B., Flister, M. J., & Joshi, A. (2020) · Theranostics · doi:10.7150/thno.41171 · Cited by 15 · see citing works
Nanoparticles Functionalized with Ligands of Cell Surface Nucleolin for Cancer Therapy and Diagnosis
Sader, M. (2015) · Journal of Nanomedicine & Nanotechnology · doi:10.4172/2157-7439.1000310 · Cited by 14 · see citing works
Leaderer, D., Cashman, S., & Kumar-Singh, R. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.02.009 · Cited by 12 · see citing works
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection
Pålsson, S. A., Dondalska, A., Bergenstråhle, J., Rolfes, C., Björk, A., Sedano, L., Power, U. F., Rameix‐Welti, M., Lundeberg, J., Wahren‐Herlenius, M., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.580547 · Cited by 12 · see citing works
Paclitaxel modified Fe 3 O 4 loaded albumin nanoparticles as drug delivery vehicles by self-assembly
Tang, X., Ben-lan, L., Cui, S., Zhang, X., Yang, Z., Wu, Q., Zhang, X., Shen, X., & Wang, T. (2016) · RSC Advances · doi:10.1039/c6ra04659b · Cited by 11 · see citing works
Self-citationAptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells
Leandro, L. D., Giansanti, F., Mei, S., Ponziani, S., Colasante, M., Ardini, M., Angelucci, F., Pitari, G., d’Angelo, M., Cimini, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.588306 · Cited by 11 · see citing works
- Authors
- Wu, J., Song, C., Jiang, C., Shen, X., Qiao, Q., & Hu, Y.
- Affiliations
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Corresponding author
- Wu, Jinhui
- Hu, Yiqiao
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-08-28
- Volume
- 10
- Issue
- 10
- Pages
- 3555-3563
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2004023680
- Cited by
- 125
- References
- 32
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 14 · 2020: 16 · 2019: 10 · 2018: 13 · 2017: 15 · 2016: 12 · 2015: 14 · 2014: 5 · 2012: 1
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- nucleolin, protein nanoparticles, human serum albumin, targeted drug delivery, paclitaxel, MCF-7 cells, endostatin, nanoparticle uptake, self-assembly, tumor targeting
- MeSH terms
- Nucleolin, Animals, Antineoplastic Agents, Cell Line, Cell Membrane, Cell Survival, Humans, Phosphoproteins, 3T3 Cells, RNA-Binding Proteins, Paclitaxel, Endostatins, Mice, Nanoparticles, MCF-7 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review