Cited by 779Nanoparticle-Based Drug DeliveryCancer Treatment and PharmacologyProtein Interaction Studies and Fluorescence Analysis

Protein nanoparticles as drug carriers in clinical medicine

Hawkins, Michael J., Soon-Shiong, Patrick, Desai, Neil·2008·Advanced Drug Delivery Reviews

Abstract

Solvent-based delivery vehicles for chemotherapy agents have been instrumental in providing a means for hydrophobic agents to be administered intravenously. These solvents, however, have been associated with serious and dose-limiting toxicities. Solvent-based formulations of taxanes, a highly active class of cytotoxic agents, are associated with hypersensitivity reactions, neutropenia, and neuropathy. Nanoparticle technology utilizing the human protein albumin exploits natural pathways to selectively deliver larger amounts of drug to tumors while avoiding some of the toxicities of solvent-based formulations. 130 nM albumin-bound (nab) paclitaxel (nab-paclitaxel; Abraxane) was recently approved for use in patients with metastatic breast cancer who have failed combination therapy. In a randomized, phase III study in metastatic breast cancer, nab-paclitaxel was found to have improved efficacy and safety compared with conventional, solvent-based paclitaxel. Preliminary data also suggest roles for nab-paclitaxel as a single agent and in combination therapy for first-line treatment of metastatic breast cancer as well as in other solid tumors, including non-small-cell lung cancer, ovarian cancer, and malignant melanoma. The nab technology promises to have broad utility in cancer therapy, and clinical trials are underway using nab formulations of other water-insoluble anticancer agents such as docetaxel and rapamycin.

Integrity signals

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Crossref · 10.1016/j.addr.2007.08.044

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  • Protein can interact with the glycoprotein receptor and facilitate the transcytosis of molecules that are bound to albumin.

    “Additionally, protein can interact with the glycoprotein receptor and facilitate the transcytosis of molecules that are bound to albumin.63”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [63]

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Authors
Hawkins, M. J., Soon-Shiong, P., & Desai, N.
Affiliations
Abraxis (United States) (US)
Corresponding author
Hawkins, Michael J.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2008-05
Volume
60
Issue
8
Pages
876-885
ISSN
0169-409X (ISSN-L)
OpenAlex
W2030173263
Cited by
779
References
64
Citations by year
2026: 20 · 2025: 25 · 2024: 36 · 2023: 40 · 2022: 44 · 2021: 40 · 2020: 52 · 2019: 58 · 2018: 54 · 2017: 46 · 2016: 63 · 2015: 57 · 2014: 52 · 2013: 55 · 2012: 39
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Comprehensive Cancer Network
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
Keywords
nab-paclitaxel, protein nanoparticles, albumin, drug carriers, taxanes, chemotherapy toxicity, metastatic breast cancer, non-small cell lung cancer, ovarian cancer, melanoma, docetaxel, rapamycin, targeted drug delivery
MeSH terms
Albumin-Bound Paclitaxel, Albumins, Antineoplastic Agents, Phytogenic, Clinical Trials as Topic, Drug Carriers, Humans, Neoplasms, Paclitaxel, Nanotechnology, Nanoparticles

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