Protein nanoparticles as drug carriers in clinical medicine
Abstract
Solvent-based delivery vehicles for chemotherapy agents have been instrumental in providing a means for hydrophobic agents to be administered intravenously. These solvents, however, have been associated with serious and dose-limiting toxicities. Solvent-based formulations of taxanes, a highly active class of cytotoxic agents, are associated with hypersensitivity reactions, neutropenia, and neuropathy. Nanoparticle technology utilizing the human protein albumin exploits natural pathways to selectively deliver larger amounts of drug to tumors while avoiding some of the toxicities of solvent-based formulations. 130 nM albumin-bound (nab) paclitaxel (nab-paclitaxel; Abraxane) was recently approved for use in patients with metastatic breast cancer who have failed combination therapy. In a randomized, phase III study in metastatic breast cancer, nab-paclitaxel was found to have improved efficacy and safety compared with conventional, solvent-based paclitaxel. Preliminary data also suggest roles for nab-paclitaxel as a single agent and in combination therapy for first-line treatment of metastatic breast cancer as well as in other solid tumors, including non-small-cell lung cancer, ovarian cancer, and malignant melanoma. The nab technology promises to have broad utility in cancer therapy, and clinical trials are underway using nab formulations of other water-insoluble anticancer agents such as docetaxel and rapamycin.
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Protein can interact with the glycoprotein receptor and facilitate the transcytosis of molecules that are bound to albumin.
“Additionally, protein can interact with the glycoprotein receptor and facilitate the transcytosis of molecules that are bound to albumin.63”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [63]
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- Authors
- Hawkins, M. J., Soon-Shiong, P., & Desai, N.
- Affiliations
- Abraxis (United States) (US)
- Corresponding author
- Hawkins, Michael J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 60
- Issue
- 8
- Pages
- 876-885
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2030173263
- Cited by
- 779
- References
- 64
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 36 · 2023: 40 · 2022: 44 · 2021: 40 · 2020: 52 · 2019: 58 · 2018: 54 · 2017: 46 · 2016: 63 · 2015: 57 · 2014: 52 · 2013: 55 · 2012: 39
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Comprehensive Cancer Network
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- nab-paclitaxel, protein nanoparticles, albumin, drug carriers, taxanes, chemotherapy toxicity, metastatic breast cancer, non-small cell lung cancer, ovarian cancer, melanoma, docetaxel, rapamycin, targeted drug delivery
- MeSH terms
- Albumin-Bound Paclitaxel, Albumins, Antineoplastic Agents, Phytogenic, Clinical Trials as Topic, Drug Carriers, Humans, Neoplasms, Paclitaxel, Nanotechnology, Nanoparticles
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