The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Solid State Amorphization of Pharmaceuticals
Abstract
Amorphous solids are conventionally formed by supercooling liquids or by concentrating noncrystallizing solutes (spray-drying and freeze-drying). However, a lot of pharmaceutical processes may also directly convert compounds from crystal to noncrystal which may have desired or undesired consequences for their stability. The purpose of this short review paper is (i) to illustrate the possibility to amorphize one compound by several different routes (supercooling, dehydration of hydrate, milling, annealing of metastable crystalline forms), (ii) to examine factors that favor crystal to glass rather than crystal to crystal transformations, (iii) to discuss the role of possible amorphous intermediates in solid-solid conversions induced by milling, (iv) to address the issue of chemical stability in the course of solid state amorphization, (v) to discuss the nature of the amorphous state obtained by the nonconventional routes, (vi) to show the effect of milling conditions on glasses properties, and (vii) to attempt to rationalize the observed transformations using the concepts of effective temperature introduced in nonequilibrium physics.
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Citations
Cites
On the Temperature Dependence of Cooperative Relaxation Properties in Glass-Forming Liquids
Adam, G., & Gibbs, J. H. (1965) · The Journal of Chemical Physics · doi:10.1063/1.1696442 · Cited by 5,836
Supercooled liquids and the glass transition
Debenedetti, P. G., & Stillinger, F. H. (2001) · Nature · doi:10.1038/35065704 · Cited by 4,643
Relaxation in glassforming liquids and amorphous solids
Angell, C. A., Ngai, K. L., McKenna, G. B., McMillan, P. F., & Martin, S. W. (2000) · Journal of Applied Physics · doi:10.1063/1.1286035 · Cited by 2,238
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Hancock, B. C., & Zografi, G. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js9601896 · Cited by 1,922
Metastable Liquids: Concepts and Principles
Debenedetti, P. G. (1996) · Cited by 1,468
A kinetic treatment of glass formation
Uhlmann, D. R. (1972) · Journal of Non-Crystalline Solids · doi:10.1016/0022-3093(72)90269-4 · Cited by 825
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Kelton, K. F. (1991) · Solid State Physics · doi:10.1016/s0081-1947(08)60144-7 · Cited by 766
Structure and order in thermal dehydrations of crystalline solids
Galwey, A. K. (2000) · Thermochimica Acta · doi:10.1016/s0040-6031(00)00448-2 · Cited by 235
How does grinding produce co-crystals? Insights from the case of benzophenone and diphenylamine
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Interpretation of Relaxation Time Constants for Amorphous Pharmaceutical Systems
Shamblin, S. L., Hancock, B. C., Dupuis, Y., & Pikal, M. J. (2000) · Journal of Pharmaceutical Sciences · doi:10.1002/(sici)1520-6017(200003)89:3<417::aid-jps12>3.0.co;2-v · Cited by 152
Cited by
Review: physical chemistry of solid dispersions
Janssens, S., & Van den Mooter, G. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.12.0001 · Cited by 580
Wang, M., Wang, J., Zhang, Y., Xia, Q., Bi, W., Yang, X., & Chen, D. D. Y. (2016) · Journal of Chromatography A · doi:10.1016/j.chroma.2016.03.061 · Cited by 108
Smith, G., Hussain, A., Bukhari, N. I., & Ermolina, I. (2015) · Journal of Thermal Analysis and Calorimetry · doi:10.1007/s10973-015-4469-4 · Cited by 18
Metadata
- Authors
- Willart, J. F., & Descamps, M.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-10-28
- Volume
- 5
- Issue
- 6
- Pages
- 905-920
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W1965469157
- Cited by
- 332
- References
- 19
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
