The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Regulating Immune Response Using Polyvalent Nucleic Acid−Gold Nanoparticle Conjugates
Open accessAbstract
The immune response of macrophage cells to internalized polyvalent nucleic acid-functionalized gold nanoparticles has been studied. This study finds that the innate immune response (as measured by interferon-beta levels) to densely functionalized, oligonucleotide-modified nanoparticles is significantly less (up to a 25-fold decrease) when compared to a lipoplex carrying the same DNA sequence. The magnitude of this effect is inversely proportional to oligonucleotide density. It is proposed that the enzymes involved in recognizing foreign nucleic acids and triggering the immune response are impeded due to the local surface environment of the particle, in particular high charge density. The net effect is an intracelluar gene regulation agent that elicits a significantly lower cellular immune response than conventional DNA transfection materials.
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Citations
Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Nanostructures in Biodiagnostics
Rosi, N. L., & Mirkin, C. A. (2005) · Chemical Reviews · doi:10.1021/cr030067f · Cited by 4,603
Self-citationThe effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
Targeted Delivery of Small Interfering RNA: Approaching Effective Cancer Therapies
Pirollo, K. F., & Chang, E. H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5810 · Cited by 121
Cited by
Gold Nanoparticles for Nucleic Acid Delivery
Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., & Rotello, V. M. (2014) · Molecular Therapy · doi:10.1038/mt.2014.30 · Cited by 521
The landscape of nanoparticle-based siRNA delivery and therapeutic development
Moazzam, M., Zhang, M., Hussain, A., Yu, X., Huang, J., & Huang, Y. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.005 · Cited by 230
Metadata
- Authors
- Massich, M. D., Giljohann, D. A., Seferos, D. S., Ludlow, L. E., Horvath, C. M., & Mirkin, C. A.
- Venue
- Molecular Pharmaceutics
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-10-07
- Volume
- 6
- Issue
- 6
- Pages
- 1934-1940
- ISSN
- 1543-8384 (ISSN-L)
- 1543-8392
- OpenAlex
- W2010447672
- Cited by
- 163
- References
- 5
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- green
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