Immunological properties of engineered nanomaterials

In vivo cancer targeting and imaging with semiconductor quantum dots

Gao, X., Cui, Y., Levenson, R. M., Chung, L. W. K., & Nie, S. (2004) · Nature Biotechnology · doi:10.1038/nbt994 · Cited by 4,775 · see citing works

Regulated portals of entry into the cell

Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,816 · see citing works

Long-Circulating and Target-Specific Nanoparticles: Theory to Practice

Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works

Biodegradable Long-Circulating Polymeric Nanospheres

Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V. S., Torchilin, V. P., & Langer, R. (1994) · Science · doi:10.1126/science.8128245 · Cited by 2,924 · see citing works

Mechanisms of phagocytosis in macrophages

Aderem, A., & Underhill, D. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.593 · Cited by 2,854 · see citing works

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

Gradishar, W. J., Tjulandin, S., Davidson, N. G. P., Shaw, H., Desai, N. P., Bhar, P., Hawkins, M., & O’Shaughnessy, J. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.04.937 · Cited by 2,159 · see citing works

Role of target geometry in phagocytosis

Champion, J. A., & Mitragotri, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600997103 · Cited by 2,082 · see citing works

‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption

Gref, R., Lück, M., Quellec, P., Marchand, M., Dellacherie, E., Harnisch, S., Blunk, T., & Müller, R. H. (2000) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(99)00156-3 · Cited by 1,725 · see citing works

Biocompatibility of Gold Nanoparticles and Their Endocytotic Fate Inside the Cellular Compartment: A Microscopic Overview

Shukla, R., Bansal, V., Chaudhary, M., Basu, A., Bhonde, R. R., & Sastry, M. (2005) · Langmuir · doi:10.1021/la0513712 · Cited by 1,689 · see citing works

Quantum Dots as Cellular Probes

Alivisatos, A. P., Gu, W., & Larabell, C. A. (2005) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.7.060804.100432 · Cited by 1,368 · see citing works

Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Reddy, S. T., van der Vlies, A. J., Simeoni, E., Angeli, V., Randolph, G. J., O’Neil, C. P., Lee, L. K., Swartz, M. A., & Hubbell, J. A. (2007) · Nature Biotechnology · doi:10.1038/nbt1332 · Cited by 1,355 · see citing works

Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

Shvedova, A. A., Kisin, E. R., Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. I., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., et al. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00084.2005 · Cited by 1,312 · see citing works

Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties

Moghimi, S. M., & Szebeni, J. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00033-x · Cited by 1,228 · see citing works

Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery

Paciotti, G. F., Myer, L. D., Weinreich, D. M., Goia, D. V., Pavel, N., McLaughlin, R. E., & Tamarkin, L. (2004) · Drug Delivery · doi:10.1080/10717540490433895 · Cited by 1,184 · see citing works

Vaccine adjuvants: Current state and future trends

Petrovsky, N., & Aguilar, J. C. (2004) · Immunology and Cell Biology · doi:10.1111/j.0818-9641.2004.01272.x · Cited by 1,006 · see citing works

Carbon nanotubes show no sign of acute toxicity but induce intracellular reactive oxygen species in dependence on contaminants

Pulskamp, K., Diabaté, S., & Krug, H. F. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.11.001 · Cited by 1,003 · see citing works

Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles

Xu, Y., & Du, Y. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00548-3 · Cited by 819 · see citing works

Parameters influencing the stealthiness of colloidal drug delivery systems

Vonarbourg, A., Passirani, C., Saulnier, P., & Benoit, J.-P. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.039 · Cited by 740 · see citing works

PLGA Nanoparticles in Drug Delivery: The State of the Art;

Bala, I., Hariharan, S., & Kumar, M. R. (2004) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v21.i5.20 · Cited by 739 · see citing works

Size-Dependent Immunogenicity: Therapeutic and Protective Properties of Nano-Vaccines against Tumors

Fifis, T., Gamvrellis, A., Crimeen‐Irwin, B., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3148 · Cited by 664 · see citing works

Nanoparticle‐induced platelet aggregation and vascular thrombosis

Radomski, A. S., Jurasz, P., Alonso‐Escolano, D., Drews, M., Morandi, M. T., Maliñski, T., & Radomski, M. W. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706386 · Cited by 636 · see citing works

Nanotechnology for the biologist

McNeil, S. E. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0205074 · Cited by 622 · see citing works

Pathogen recognition and development of particulate vaccines: Does size matter?

Xiang, S. D., Scholzen, A., Minigo, G., David, C. T., Apostolopoulos, V., Mottram, P. L., & Plebanski, M. (2006) · Methods · doi:10.1016/j.ymeth.2006.05.016 · Cited by 602 · see citing works

Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles

Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.05.022 · Cited by 586 · see citing works

Preliminary biological evaluation of polyamidoamine (PAMAM) StarburstTM dendrimers

Roberts, J. C., Bhalgat, M. K., & Zera, R. T. (1996) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199601)30:1 · Cited by 581 · see citing works

Complement activation and protein adsorption by carbon nanotubes

Salvador-Morales, C., Emmanuel Flahaut, B., Sim, E., Sloan, J., HGREEN, M., & Sim, R. B. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.02.006 · Cited by 433 · see citing works

In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size

Fang, C., Shi, B., Pei, Y., Hong, M., Wu, J., & Chen, H. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.002 · Cited by 424 · see citing works

Nanoparticles with decreasing surface hydrophobicities: influence on plasma protein adsorption

Gessner, A., Waicz, R., Lieske, A., Paulke, B. ‐., Mäder, K., & Müller, R. H. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00432-9 · Cited by 358 · see citing works

Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis

Gessner, A., Lieske, A., Paulke, B., & Müller, R. H. (2002) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(02)00081-4 · Cited by 356 · see citing works

Preclinical safety evaluation of biotechnology-derived pharmaceuticals

Cavagnaro, J. A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd822 · Cited by 340 · see citing works

Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation

Shaunak, S., Thomas, S., Gianasi, E., Godwin, A., Jones, E., Teo, I. A., Mireskandari, K., Luthert, P. J., Duncan, R., Patterson, S., et al. (2004) · Nature Biotechnology · doi:10.1038/nbt995 · Cited by 331 · see citing works

Macrophage Uptake of Core−Shell Nanoparticles Surface Modified with Poly(ethylene glycol)

Zahr, A. S., Davis, C. A., & Pishko, M. V. (2006) · Langmuir · doi:10.1021/la060951b · Cited by 324 · see citing works

On regulation of phagosome maturation and antigen presentation

Blander, J. M., & Medzhitov, R. M. (2006) · Nature Immunology · doi:10.1038/ni1006-1029 · Cited by 310 · see citing works

Current Status and Future Prospects

Wood, C. E., Baker, G., & Trounson, A. (1984) · Springer eBooks · doi:10.1007/978-1-4471-3317-9_2 · Cited by 306 · see citing works

Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns

Göppert, T. M., & Müller, R. H. (2005) · Journal of drug targeting · doi:10.1080/10611860500071292 · Cited by 299 · see citing works

Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice

Oyewumi, M. O., Yokel, R. A., Jay, M., Coakley, T., & Mumper, R. J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.01.002 · Cited by 296 · see citing works

Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent

Enochs, W. S., Harsh, G. R., Hochberg, F. H., & Weissleder, R. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199902)9:2 · Cited by 247 · see citing works

Detoxification of Gold Nanorods by Treatment with Polystyrenesulfonate

Leonov, A. P., Zheng, J., Clogston, J. D., et al. (2008) · ACS Nano · doi:10.1021/nn800466c · Cited by 247 · see citing works

Functional groups on polystyrene model nanoparticles: Influence on protein adsorption

Gessner, A., Lieske, A., Paulke, B., & Müller, R. H. (2003) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.10371 · Cited by 239 · see citing works

The Importance of an Endotoxin-Free Environment during the Production of Nanoparticles Used in Medical Applications

Vallhov, H., Qin, J., Johansson, S. M., Ahlborg, N., Muhammed, M. A., Scheynius, A., & Gabrielsson, S. (2006) · Nano Letters · doi:10.1021/nl060860z · Cited by 238 · see citing works

Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro

Müller, K. H., Skepper, J. N., Pósfai, M., Trivedi, R. A., Howarth, S. P. S., Corot, C., Lancelot, E., Thompson, P. W., Brown, A. P., & Gillard, J. H. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.12.003 · Cited by 237 · see citing works

Nanotechnology for Cancer Therapy

Narayan, M., & Pathak, V. (2006) · CRC Press eBooks · doi:10.1201/9781420006636 · Cited by 236 · see citing works

The Inhibitory Role of CpG Immunostimulatory Motifs in Cationic Lipid Vector-Mediated Transgene Expression in Vivo

Tan, Y., Li, S., Pitt, B. R., & Huang, L. (1999) · Human Gene Therapy · doi:10.1089/10430349950017149 · Cited by 235 · see citing works

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics

Nagayama, S., Ogawara, K., Fukuoka, Y., Higaki, K., & Kimura, T. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.04.036 · Cited by 225 · see citing works

Evaluation of pegylated lipid nanocapsules versus complement system activation and macrophage uptake

Vonarbourg, A., Passirani, C., Saulnier, P., Simard, P., Leroux, J., & Benoît, J. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30711 · Cited by 216 · see citing works

Antigenicity of fullerenes: Antibodies specific for fullerenes and their characteristics

Chen, B.-X., Wilson, S. R., Das, M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10809 · Cited by 211 · see citing works

Visualization of in vitro protein-rejecting properties of PEGylated stealth® polycyanoacrylate nanoparticles

Peracchia, M. T., Harnisch, S., Pinto‐Alphandary, H., Gulik, A., Dedieu, J., Desmaële, D., d’Angelo, J., Müller, R. H., & Couvreur, P. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00021-6 · Cited by 208 · see citing works

Methylation of the phosphate oxygen moiety of phospholipid‐methoxy(polyethylene glycol) conjugate prevents PEGylated liposome‐mediated complement activation and anaphylatoxin production

Moghimi, S. M., Hamad, I. M., Andresen, T. L., Jørgensen, K., & Szebeni, J. (2006) · The FASEB Journal · doi:10.1096/fj.06-6186fje · Cited by 201 · see citing works

Binding of an Anti-Fullerene IgG Monoclonal Antibody to Single Wall Carbon Nanotubes

Erlanger, B. F., Chen, B.-X., Zhu, M. H., & Brus, L. E. (2001) · Nano Letters · doi:10.1021/nl015570r · Cited by 192 · see citing works

Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery

Chong, C. S. W., Cao, M., Wong, W. W., Fischer, K. P., Addison, W. R., Kwon, G. S., Tyrrell, D. L., & Samuel, J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.014 · Cited by 191 · see citing works

Monitoring Cell Therapy Using Iron Oxide MR Contrast Agents

Bulte, J. W. M., & Kraitchman, D. L. (2004) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201043376526 · Cited by 172 · see citing works

Mannosylated chitosan nanoparticle–based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells

Kim, T. H., Jin, H., Kim, H. W., et al. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0540 · Cited by 165 · see citing works

Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice

Wang, J., Chen, C., Li, B., Yu, H., Zhao, Y., Sun, J. L., Li, Y., Xing, G., Yuan, H. Y., Tang, J., et al. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.001 · Cited by 160 · see citing works

Toxicity and Biocompatibility of Carbon Nanoparticles

Fiorito, S., Serafino, A., Andreola, F., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.125 · Cited by 158 · see citing works

Chemical modification of poly(vinyl chloride) resin using poly(ethylene glycol) to improve blood compatibility

Balakrishnan, B., Kumar, D. S., Yoshida, Y., & Jayakrishnan, A. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.09.032 · Cited by 157 · see citing works

PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques.

Francis, G. E. (1998) · International Journal of Hematology · doi:10.1016/s0925-5710(98)00039-5 · Cited by 150 · see citing works

PEGylation of microspheres generates a heterogeneous population of particles with differential surface characteristics and biological performance

Gbadamosi, J. K., Hunter, A. C., & Moghimi, S. M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03710-9 · Cited by 150 · see citing works

Treatment of experimental arthritis with poly(d, l-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate

Higaki, M., Ishihara, T., Izumo, N., et al. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.030759 · Cited by 150 · see citing works

Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles

Kwon, Y. J., Standley, S. M., Goh, S. L., et al. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.02.027 · Cited by 149 · see citing works

Protein adsorption patterns on poloxamer- and poloxamine-stabilized solid lipid nanoparticles (SLN)

Göppert, T. M., & Müller, R. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2005.02.006 · Cited by 141 · see citing works

X-ray crystal structure of an anti-Buckminsterfullerene antibody Fab fragment: Biomolecular recognition of C 60

Braden, B. C., Goldbaum, F. A., Chen, B.-X., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210396197 · Cited by 132 · see citing works

Intraocular injection of tamoxifen‐loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis

de Kozak, Y., Andrieux, K., Villarroya, H., Klein, C., Thillaye‐Goldenberg, B., Naud, M., Garcia, E., & Couvreur, P. (2004) · European Journal of Immunology · doi:10.1002/eji.200425022 · Cited by 130 · see citing works

A Murine Scavenger Receptor MARCO Recognizes Polystyrene Nanoparticles

Kanno, S., Furuyama, A., & Hirano, S. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm050 · Cited by 126 · see citing works

Blood Compatibility of Cetyl Alcohol/Polysorbate-Based Nanoparticles

Koziara, J. M., Oh, J. J., Akers, W. S., Ferraris, S. P., & Mumper, R. J. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-7547-7 · Cited by 123 · see citing works

Dose Sparing of CpG Oligodeoxynucleotide Vaccine Adjuvants by Nanoparticle Delivery

Diwan, M., Elamanchili, P., Cao, M., et al. (2004) · Current Drug Delivery · doi:10.2174/1567201043334597 · Cited by 119 · see citing works

Fullerene derivatives protect against oxidative stress in RAW 264.7 cells and ischemia-reperfused lungs

Chen, Y., Hwang, K. C., Yen, C., & Lai, Y. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00310.2003 · Cited by 118 · see citing works

Biodegradable Nanoparticle Mediated Antigen Delivery to Human Cord Blood Derived Dendritic Cells for Induction of Primary T Cell Responses

Diwan, M., Elamanchili, P., Lane, H. C., Gainer, A. L., & Samuel, J. (2003) · Journal of drug targeting · doi:10.1080/10611860410001670026 · Cited by 116 · see citing works

Systemic administration of LPD prepared with CpG oligonucleotides inhibits the growth of established pulmonary metastases by stimulating innate and acquired antitumor immune responses

Whitmore, M., Li, S., Falo, L. D., & Huang, L. (2001) · Cancer Immunology Immunotherapy · doi:10.1007/s002620100227 · Cited by 101 · see citing works

Immunostimulation Mechanism of LPD Nanoparticle as a Vaccine Carrier

Cui, Z., Han, S., Vangasseri, D. P., & Huang, L. (2004) · Molecular Pharmaceutics · doi:10.1021/mp049907k · Cited by 99 · see citing works

Plasma protein adsorption on biodegradable microspheres consisting of poly(d,l-lactide-co-glycolide), poly(l-lactide) or ABA triblock copolymers containing poly(oxyethylene)

Lück, M., Pistel, K. F., Li, Y., Blunk, T., Müller, R. H., & Kissel, T. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00030-3 · Cited by 98 · see citing works

Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques

Mühlen, C. V. Z., von Elverfeldt, D., Bassler, N., Neudorfer, I., Steitz, B., Petri‐Fink, A., Hofmann, H., Bode, C., & Peter, K. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.048 · Cited by 97 · see citing works

Inhibition of Group A Streptococcus Infection by Carboxyfullerene

Tsao, N., Luh, T., Chou, C., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.6.1788-1793.2001 · Cited by 95 · see citing works

Physical Characterization and Macrophage Cell Uptake of Mannan-Coated Nanoparticles

Cui, Z., Hsu, C.-H., & Mumper, R. J. (2003) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120021318 · Cited by 94 · see citing works

Evaluation of Methods to Detect and Characterize Antibodies against Recombinant Human Erythropoietin

Swanson, S. J., Ferbas, J., Mayeux, P., et al. (2004) · Nephron Clinical Practice · doi:10.1159/000076746 · Cited by 94 · see citing works

Biodegradable nanoparticle delivery of a Th2-biased peptide for induction of Th1 immune responses

Lutsiak, M. E. C., Kwon, G. S., & Samuel, J. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.6.0004 · Cited by 89 · see citing works

Distribution and Elimination of Coated Polymethyl [2-14C]Methacrylate Nanoparticles After Intravenous Injection in Rats

Leu, D., Manthey, B., Kreuter, J., Speiser, P. P., & Delucax, P. P. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600731028 · Cited by 88 · see citing works

Liposome-Mediated Triggering of Complement Cascade

Moghimi, S. M., & Hamad, I. M. (2008) · Journal of Liposome Research · doi:10.1080/08982100802309552 · Cited by 86 · see citing works

Activation of the Human Complement System by Cholesterol-Rich and PEGylated Liposomes—Modulation of Cholesterol-Rich Liposome-Mediated Complement Activation by Elevated Serum LDL and HDL Levels

Moghimi, S. M., Hamad, I. M., Bünger, R., Andresen, T. L., Jørgensen, K., Hunter, A. C., Baranji, L., Rosivall, L., & Szebeni, J. (2006) · Journal of Liposome Research · doi:10.1080/08982100600848801 · Cited by 79 · see citing works

Neutralizing and binding anti‐interferon‐β (IFN‐β) antibodies. A comparison between IFN‐β‐1a and IFN‐β‐1b treatment in multiple sclerosis

Kivisäkk, P., Alm, G. V., Fredrikson, S., & Link, H. (2000) · European Journal of Neurology · doi:10.1046/j.1468-1331.2000.00002.x · Cited by 76 · see citing works

Complement activation on surfaces modified with ethylene glycol units

Arima, Y., Toda, M., & Iwata, H. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.015 · Cited by 76 · see citing works

Determination of Plasma Protein Adsorption on Magnetic Iron Oxides: Sample Preparation

Thode, K., Lück, M., Semmler, W., Müller, R. H., & Kresse, M. (1997) · Pharmaceutical Research · doi:10.1023/a:1012104017761 · Cited by 74 · see citing works

A Workshop Report

Sielert, M. E., & Miller, D. (1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801600602 · Cited by 73 · see citing works

Plasma protein adsorption patterns on liposomes: Establishment of analytical procedure

Diederichs, J. E. (1996) · Electrophoresis · doi:10.1002/elps.1150170332 · Cited by 71 · see citing works

Lipid–protamine–DNA-mediated antigen delivery to antigen-presenting cells results in enhanced anti-tumor immune responses

Dileo, J., Banerjee‬‬‬‬‬‬‬‬‬, R., Whitmore, M., et al. (2003) · Molecular Therapy · doi:10.1016/s1525-0016(03)00064-9 · Cited by 69 · see citing works

Fetuin mediates hepatic uptake of negatively charged nanoparticles via scavenger receptor

Nagayama, S., Ogawara, K., Minato, K., Fukuoka, Y., Takakura, Y., Hashida, M., Higaki, K., & Kimura, T. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.025 · Cited by 68 · see citing works

Concentration Dependent Structural Ordering of Poloxamine 908 on Polystyrene Nanoparticles and Their Modulatory Role on Complement Consumption

Al-Hanbali, O. A., Rutt, K. J., Sarker, D. K., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.406 · Cited by 67 · see citing works

Development of Phosphorylated Glucomannan-Coated Chitosan Nanoparticles as Nanocarriers for Protein Delivery

Cuña, M., Alonso-Sande, M., Remuñán‐López, C., et al. (2006) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2006.435 · Cited by 66 · see citing works

Immunogenic Properties of Colloidal Gold

Dykman, L. A., Sumaroka, M. V., Staroverov, S. A., et al. (2004) · Biology Bulletin · doi:10.1023/b:bibu.0000014358.98422.9c · Cited by 63 · see citing works

Strong T cell type-1 immune responses to HIV-1 Tat (1–72) protein-coated nanoparticles

Cui, Z., Patel, J. D., Tuzova, M. N., et al. (2004) · Vaccine · doi:10.1016/j.vaccine.2003.12.013 · Cited by 62 · see citing works

Evaluation of novel aggregate structures as adjuvants: composition, toxicity studies and humoral responses

Rajananthanan, P., Attard, G. S., Sheikh, N. A., et al. (1999) · Vaccine · doi:10.1016/s0264-410x(98)00256-4 · Cited by 62 · see citing works

Cholesteryl butyrate solid lipid nanoparticles inhibit adhesion of human neutrophils to endothelial cells

Dianzani, C., Cavalli, R., Zara, G. P., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706761 · Cited by 61 · see citing works

Coating of cationized protein on engineered nanoparticles results in enhanced immune responses

Cui, Z., & Mumper, R. J. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00079-0 · Cited by 60 · see citing works

Nanoparticles as Adjuvants for Vaccines

Kreuter, J. (1995) · Pharmaceutical biotechnology · doi:10.1007/978-1-4615-1823-5_19 · Cited by 58 · see citing works

Discovery of a potent nanoparticle P‐selectin antagonist with anti‐inflammatory effects in allergic airway disease

John, A. E., Lukacs, N. W., Berlin, A. A., et al. (2003) · The FASEB Journal · doi:10.1096/fj.03-0166fje · Cited by 58 · see citing works

High antibody titres in mice with polymethylmethacrylate nanoparticles as adjuvant for HIV vaccines

Stieneker, F., Kreuter, J., & Löwer, J. (1991) · AIDS · doi:10.1097/00002030-199104000-00012 · Cited by 53 · see citing works

Preclinical Characterization of Engineered Nanoparticles Intended for Cancer Therapeutics

Patri, A. K., Dobrovolskaia, M. A., Stern, S. T., & McNeil, S. E. (2006) · CRC Press eBooks · doi:10.1201/9781420006636-7 · Cited by 51 · see citing works

Adjuvant activity of particulate pollutants in different mouse models

van Zijverden, M., & Granum, B. B. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00293-6 · Cited by 49 · see citing works

Protective efficiency of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy

Balenga, N. A. B., Zahedifard, F., Weiss, R., Sarbolouki, M. N., Thalhamer, J., & Rafati, S. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.01.014 · Cited by 46 · see citing works

Novel aggregate structure adjuvants modulate lymphocyte proliferation and Th1 and Th2 cytokine profiles in ovalbumin immunized mice

Rajananthanan, P., Attard, G. S., Sheikh, N. A., et al. (1999) · Vaccine · doi:10.1016/s0264-410x(99)00213-3 · Cited by 46 · see citing works

Assessing immunotoxicity: guidelines

Putman, E., van der Laan, J. W., & Loveren, H. V. (2003) · Fundamental and Clinical Pharmacology · doi:10.1046/j.1472-8206.2003.00181.x · Cited by 42 · see citing works

Immunotoxicology assessment in the pharmaceutical industry

Dean, J. H., Hincks, J. R., & Remandet, B. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)00314-2 · Cited by 41 · see citing works

Identification of plasma proteins facilitated by enrichment on particulate surfaces: Analysis by two‐dimensional electrophoresis and N‐terminal microsequencing

Lück, M., Schröder, W., Harnisch, S., Thode, K., Blunk, T., Paulke, B., Kresse, M., & Müller, R. H. (1997) · Electrophoresis · doi:10.1002/elps.1150181538 · Cited by 39 · see citing works

Real‐time evidence of surface modification at polystyrene lattices by poloxamine 908 in the presence of serum: in vivo conversion of macrophage‐prone nanoparticles to stealth entities by poloxamine 908

Moghimi, S. M., Pavey, K. D., & Hunter, A. C. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00707-5 · Cited by 35 · see citing works

Recognition and clearance of methoxypoly(ethyleneglycol)2000-grafted liposomes by macrophages with enhanced phagocytic capacity Implications in experimental and clinical oncology

Laverman, P. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(01)00142-8 · Cited by 34 · see citing works

Magnetic Resonance Imaging of Activated Proliferating Rhesus Macaque T Cells Labeled With Superparamagnetic Monocrystalline Iron Oxide Nanoparticles

Sundstrom, J. B., Mao, H. Z., Santoianni, R. A., Villinger, F. J., Little, D. M., Huynh, T. T., Mayne, A. E., Hao, E., & Ansari, A. A. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200401010-00002 · Cited by 33 · see citing works

Phase I study of 24-hour continuous intravenous infusion of recombinant human tumor necrosis factor.

Steinmetz, T., Schaadt, M., Gähl, R., et al. (1988) · PubMed · Cited by 32 · see citing works

An overview of scientific and regulatory issues for the immunogenicity of biological products.

Chamberlain, P., & Mire‐Sluis, A. R. (2003) · PubMed · Cited by 31 · see citing works

A new family of carriers (biovectors) enhances the immunogenicity of rabies antigens

Castignolles, N., Morgeaux, S., Gontier-Jallet, C., et al. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00043-6 · Cited by 27 · see citing works

Assessment of the Immunotoxic Potential of Human Pharmaceuticals: A Workshop Report

Putman, E., Loveren, H. V., Bode, G., et al. (2002) · Drug Information Journal · doi:10.1177/009286150203600221 · Cited by 27 · see citing works

Regulatory immunotoxicology: does the published evidence support mandatory nonclinical immune function screening in drug development?

Snodin, D. J. (2004) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2004.08.007 · Cited by 26 · see citing works

Functionalized dendrimers as endotoxin sponges

Cromer, J. R., Wood, S. J., Miller, K. A., Nguyen, T. B., & David, S. A. (2005) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2005.01.026 · Cited by 26 · see citing works

The role of proteins in the nucleation and formation of calcium-containing deposits on biomaterial surfaces

Vasin, S. L., Rosanova, I. B., & Sevastianov, V. I. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980305)39:3 · Cited by 26 · see citing works

Protein rejecting properties of PEG-grafted nanoparticles: influence of PEG-chain length and surface density evaluated by two-dimensional electrophoresis and bicinchoninic acid (BCA)-proteinassay.

Gessner, A., Paulke, B. ‐., Müller, R. H., et al. (2006) · PubMed · Cited by 22 · see citing works

Immunogenic and allergenic properties of fulleren conjugates with aminoacids and proteins.

Andreev, S. M., Babakhin, A. A., Petrukhina, A. O., et al. (2002) · PubMed · Cited by 22 · see citing works

Passive Transfer of Polyethylene Glycol to Liposomal-Recombinant Human FVIII Enhances its Efficacy in a Murine Model for Hemophilia A

Ramani, K., Purohit, V. S., Miclea, R. D., Gaitonde, P., Straubinger, R. M., & Balu‐Iyer, S. V. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21266 · Cited by 20 · see citing works

PRODUCTION OF ANTI-PLATELET-ACTIVATING FACTOR ANTIBODIES BY THE USE OF COLLOIDAL GOLD AS CARRIER

TOMII, A., & Masugi, F. (1991) · Japanese Journal of Medical Science and Biology · doi:10.7883/yoken1952.44.75 · Cited by 14 · see citing works

[Immunostimulating effect of water-soluble fullerene derivatives--perspective adjuvants for a new generation of vaccine].

Masalova, O. V., Av, S., Sn, A., et al. (1999) · PubMed · Cited by 14 · see citing works

Alternatives to blood in the 21st century.

Cohn, S. M. (2004) · Critical Care · doi:10.1186/cc2412 · Cited by 9 · see citing works

Dendrimer drugs prevent scar tissue formation.

Shaunak, S. (2004) · PubMed · Cited by 5 · see citing works

Understanding biophysicochemical interactions at the nano–bio interface

Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083 · see citing works

Strategies in the design of nanoparticles for therapeutic applications

Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651 · see citing works

Progress and challenges towards targeted delivery of cancer therapeutics

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220 · see citing works

Engineered Nanoparticles for Drug Delivery in Cancer Therapy

Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164 · see citing works

Design of polymeric nanoparticles for biomedical delivery applications

Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717 · see citing works

Challenges in Development of Nanoparticle-Based Therapeutics

Desai, N. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9339-4 · Cited by 1,173 · see citing works

The big picture on nanomedicine: the state of investigational and approved nanomedicine products

Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.05.013 · Cited by 1,088 · see citing works

Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution

Dobrovolskaia, M. A., Aggarwal, P., Hall, J. B., & McNeil, S. E. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800032f · Cited by 1,022 · see citing works

Minireview: Nanoparticles and the Immune System

Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914 · see citing works

Enzyme-responsive nanoparticles for drug release and diagnostics

de la Rica, R., Aili, D., & Stevens, M. M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.002 · Cited by 765 · see citing works

Design considerations for tumour-targeted nanoparticles

Choi, H. S., Liu, W., Liu, F., Nasr, K., Misra, P., Bawendi, M. G., & Frangioni, J. V. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.314 · Cited by 754 · see citing works

Nanodelivery of nucleic acids

Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00104-y · Cited by 719 · see citing works

Nanotoxicology: An Interdisciplinary Challenge

Krug, H. F., & Wick, P. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201001037 · Cited by 556 · see citing works

Nanomaterials for Neural Interfaces

Kotov, N. A., Winter, J. O., Clements, I. P., Jan, E., Timko, B. P., Campidelli, S., Pathak, S., Mazzatenta, A., Lieber, C. M., Prato, M., et al. (2009) · Advanced Materials · doi:10.1002/adma.200801984 · Cited by 504 · see citing works

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Casalini, T., Rossi, F., Castrovinci, A., & Perale, G. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00259 · Cited by 500 · see citing works

The progress of silver nanoparticles in the antibacterial mechanism, clinical application and cytotoxicity

You, C., Han, C., Wang, X., Zheng, Y., Li, Q., Hu, X., & Sun, H. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1792-8 · Cited by 447 · see citing works

Perspectives and opportunities for nanomedicine in the management of atherosclerosis

Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works

Non-viral delivery systems for CRISPR/Cas9-based genome editing: challenges and opportunities

Li, L., Hu, S., & Chen, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.031 · Cited by 415 · see citing works

Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles

Arvizo, R. R., Miranda, O. R., Moyano, D. F., Walden, C. A., Giri, K., Bhattacharya, R., Robertson, J. D., Rotello, V. M., Reid, J. M., & Mukherjee, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024374 · Cited by 403 · see citing works

Role of integrated cancer nanomedicine in overcoming drug resistance

Iyer, A. K., Singh, A., Ganta, S., & Amiji, M. M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.012 · Cited by 343 · see citing works

Breaking Down the Barriers to Precision Cancer Nanomedicine

von Roemeling, C., Jiang, W., Chan, C. K., Weissman, I. L., & Kim, B. Y. S. (2017) · Trends in Biotechnology · doi:10.1016/j.tibtech.2016.07.006 · Cited by 330 · see citing works

A Raman-based endoscopic strategy for multiplexed molecular imaging

Zavaleta, C. L., Garai, E., Liu, J. T. C., Sensarn, S., Mandella, M. J., Van de Sompel, D., Friedland, S., Van Dam, J., Contag, C. H., & Gambhir, S. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211309110 · Cited by 238 · see citing works

Nanotechnology—novel therapeutics for CNS disorders

Srikanth, M., & Kessler, J. A. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.76 · Cited by 198 · see citing works

Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos?

Sanchez, V. C., Pietruska, J. R., Miselis, N. R., Hurt, R. H., & Kane, A. B. (2009) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.41 · Cited by 186 · see citing works

Platelet-mimicking nanoparticles co-loaded with W18O49 and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy

Zuo, H., Tao, J., Shi, H., He, J., Zhou, Z., & Zhang, C. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.017 · Cited by 170 · see citing works

Polyethylenimine-coated SPIONs trigger macrophage activation through TLR-4 signaling and ROS production and modulate podosome dynamics

Mulens-Arias, V., Rojas, J. M., Pérez-Yagüe, S., Morales, M. P., & Barber, D. F. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.068 · Cited by 150 · see citing works

The role of surface chemistry in determining in vivo biodistribution and toxicity of CdSe/ZnS core–shell quantum dots

Tang, Y., Han, S., Liu, H., Chen, X., Huang, L., Li, X., & Zhang, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.087 · Cited by 147 · see citing works

Modulation of foreign body reaction and macrophage phenotypes concerning microenvironment

Chu, C., Liu, L., Rung, S., Wang, Y., Ma, Y., Hu, C., Zhao, X., Man, Y., & Qu, Y. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36798 · Cited by 131 · see citing works

Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications

Remya, N. S., Syama, S., Sabareeswaran, A., & Mohanan, P. V. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.119 · Cited by 97 · see citing works

Biomedical nanoparticles modulate specific CD4⁺T cell stimulation by inhibition of antigen processing in dendritic cells

Blank, F., Gerber, P., Rothen-Rutishauser, B., Sakulkhu, U., Salaklang, J., De Peyer, K., Gehr, P., Nicod, L. P., Hofmann, H., Geiser, T., et al. (2011) · Nanotoxicology · doi:10.3109/17435390.2010.541293 · Cited by 97 · see citing works

Modulation of Macrophage Phenotype by Biodegradable Polyurethane Nanoparticles: Possible Relation between Macrophage Polarization and Immune Response of Nanoparticles

Huang, Y.-J., Hung, K.-C., Hung, H.-S., & Hsu, S.-H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b04718 · Cited by 89 · see citing works

Liposomes with cyclic RGD peptide motif triggers acute immune response in mice

Wang, X., Wang, H., Jiang, K., Zhang, Y., Zhan, C., Ying, M., Zhang, M., Lu, L., Wang, R., Wang, S., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.003 · Cited by 56 · see citing works

Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages

Dong, P.-X., Wan, B., Wang, Z.-X., Guo, L.-H., Yang, Y., & Zhao, L. (2013) · Nanotoxicology · doi:10.3109/17435390.2012.694487 · Cited by 42 · see citing works

Summary report of PQRI workshop on nanomaterial in drug products: current experience and management of potential risks

Bartlett, J. A., Brewster, M., Brown, P., Cabral-Lilly, D., Cruz, C. N., David, R., Eickhoff, W. M., Haubenreisser, S., Jacobs, A., Malinoski, F., et al. (2015) · The AAPS Journal · doi:10.1208/s12248-014-9701-9 · Cited by 25 · see citing works

Covalent immobilization of MSC-affinity peptide on poly(L-lactide-co-ε-caprolactone) copolymer to enhance stem cell adhesion and retention for tissue engineering applications

Shafiq, M., & Kim, S. H. (2016) · Macromolecular Research · doi:10.1007/s13233-016-4138-x · Cited by 20 · see citing works

Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms

Pisanic, T. R., Jin, S., & Shubayev, V. I. (2009) · doi:10.1002/9780470747803.ch20 · Cited by 42 · see citing works

Application of Embryonic and Adult Zebrafish for Nanotoxicity Assessment

Wang, J., Zhu, X., Chen, Y., et al. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-002-1_20 · Cited by 12 · see citing works

Nanotoxicity Assessment: A Necessity

Joshi, M., & Prabhakar, B. R. (2019) · Nanoscience &amp Nanotechnology-Asia · doi:10.2174/2210681209666190228142315 · Cited by 2 · see citing works

Controllable one dimensional FePt nanomaterials synthesized by chemical method

Pei, W., Zhang, Y., Wu, C. H., et al. (2015) · IEEE International Magnetics Conference · doi:10.1109/intmag.2015.7156929

Application of nanoparticles size analyzer to study inorganic function materials

Ouyang, J. (2008) · Journal of Functional Biomaterials