The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Protein Encapsulation via Polypeptide Complex Coacervation
Abstract
Proteins have gained increasing success as therapeutic agents; however, challenges exist in effective and efficient delivery. In this work, we present a simple and versatile method for encapsulating proteins via complex coacervation with oppositely charged polypeptides, poly(l-lysine) (PLys) and poly(d/l-glutamic acid) (PGlu). A model protein system, bovine serum albumin (BSA), was incorporated efficiently into coacervate droplets via electrostatic interaction up to a maximum loading of one BSA per PLys/PGlu pair and could be released under conditions of decreasing pH. Additionally, encapsulation within complex coacervates did not alter the secondary structure of the protein. Lastly the complex coacervate system was shown to be biocompatible and interact well with cells in vitro. A simple, modular system for encapsulation such as the one presented here may be useful in a range of drug delivery applications.
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Cites
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
PEGylation of therapeutic proteins
Jevševar, S., Kunstelj, M., & Porekar, V. G. (2010) · Biotechnology Journal · doi:10.1002/biot.200900218 · Cited by 681
Delivery of Therapeutic Proteins
Pisal, D. S., Kosloski, M. P., & Balu-Iyer, S. V. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22054 · Cited by 532
Outpatient Insulin Therapy in Type 1 and Type 2 Diabetes Mellitus: Scientific Review
DeWitt, D. E., & Hirsch, I. B. (2003) · JAMA · doi:10.1001/jama.289.17.2254 · Cited by 502
Cited by
Recent progress in synthesis and application of mussel-inspired adhesives
Guo, Q., Chen, J., Wang, J., Zeng, H., & Yu, J. (2020) · Nanoscale · doi:10.1039/c9nr09780e · Cited by 370
Phase Behavior and Salt Partitioning in Polyelectrolyte Complex Coacervates
Li, L., Srivastava, S., Andreev, M., Marciel, A. B., de Pablo, J. J., & Tirrell, M. V. (2018) · Macromolecules · doi:10.1021/acs.macromol.8b00238 · Cited by 357
Self-citationComplex coacervate‐based materials for biomedicine
Blocher, W. C., & Perry, S. L. (2017) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1442 · Cited by 312
Self-citationAwada, H. K., Johnson, N. R., & Wang, Y. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.034 · Cited by 138
Metadata
- Authors
- Black, K. A., Priftis, D., Perry, S. L., Yip, J., Byun, W. Y., & Tirrell, M.
- Venue
- ACS Macro Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-10-09
- Volume
- 3
- Issue
- 10
- Pages
- 1088-1091
- ISSN
- 2161-1653 (ISSN-L)
- OpenAlex
- W2335336849
- Cited by
- 316
- References
- 4
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Black, K. A., Priftis, D., Perry, S. L., Yip, J., Byun, W. Y., & Tirrell, M. (2014). Protein Encapsulation via Polypeptide Complex Coacervation. ACS Macro Letters. https://doi.org/10.1021/mz500529v
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