Delivery of Therapeutic Proteins

Recent advances with liposomes as pharmaceutical carriers

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Effect of pegylation on pharmaceuticals

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PEGylation, successful approach to drug delivery

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Chemistry for peptide and protein PEGylation

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Formulation of functionalized PLGA-PEG Nanoparticles for in vivo targeted drug delivery

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Peptide and protein PEGylation

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Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives

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Pharmacokinetic and biodistribution properties of poly(ethylene glycol)–protein conjugates

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Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS

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Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology

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Pegylation

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Antibody Pharmacokinetics and Pharmacodynamics

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Pathogenesis, Natural History, Treatment, and Prevention of Hepatitis C

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Solid lipid nanoparticles as a drug delivery system for peptides and proteins☆

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Biodegradable microspheres for protein delivery

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Responsive polymeric delivery systems

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PLGA–lecithin–PEG core–shell nanoparticles for controlled drug delivery

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A Randomized, Double–Blind Trial Comparing Pegylated Interferon Alfa–2B to Interferon Alfa–2B As Initial Treatment for Chronic Hepatitis C

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Polymer–drug conjugation, recent achievements and general strategies

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PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats

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Diversity in cell surface sialic acid presentations: implications for biology and disease

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Preparation and characterization of cationic PLGA nanospheres as DNA carriers

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Which polymers can make nanoparticulate drug carriers long-circulating?

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The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics

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Lipid-based systemic delivery of siRNA

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Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins

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PEG conjugates in clinical development or use as anticancer agents: An overview

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The uses and properties of PEG-linked proteins.

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Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

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Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles.

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Suggestions for “safe” residue substitutions in site-directed mutagenesis

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Lymphatic uptake and biodistribution of liposomes after subcutaneous injection.

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Recombinant expression systems in the pharmaceutical industry

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Steric exclusion is the principal source of the preferential hydration of proteins in the presence of polyethylene glycols

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Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

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Development and characterization of novel erythropoiesis stimulating protein (NESP)

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Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

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Mono-N-terminal poly(ethylene glycol)–protein conjugates

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Enzymatic conversion of proteins to glycoproteins.

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Pharmacokinetic aspects of biotechnology products.

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The therapeutic value of poly(ethylene glycol)-modified proteins

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Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

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A Branched Monomethoxypoly(ethylene glycol) for Protein Modification

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Liposome circulation time and tumor targeting: implications for cancer chemotherapy

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Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase

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Introduction and overview of peptide and protein pegylation

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Site-specific PEGylation of a lysine-deficient TNF-α with full bioactivity

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Improving the therapeutic efficacy of peptides and proteins: A role for polysialic acids

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Enzymatic procedure for site-specific pegylation of proteins

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PEGylation: An Approach for Drug Delivery. A Review

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Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective

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The safety and efficacy of B‐domain deleted recombinant factor VIII concentrate in patients with severe haemophilia A

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Polysialic acid: three-dimensional structure, biosynthesis and function

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Functional Characterization of an Endosome-disruptive Peptide and Its Application in Cytosolic Delivery of Immunoliposome-entrapped Proteins

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PEG-ADA replacement therapy for adenosine deaminase deficiency: an update after 8.5 years

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Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat

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Enzymatic degradation behavior and mechanism of Poly(lactide-co-glycolide) foams by trypsin

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PLGA nanoparticles of different surface properties: Preparation and evaluation of their body distribution

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Nanostructured lipid carrier-based hydrogel formulations for drug delivery: A comprehensive review

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Site-Directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site

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%Thermogelling Biodegradable Copolymer Aqueous Solutions for Injectable Protein Delivery and Tissue Engineering

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Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study

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Efficacy and safety of liposomal anthracyclines in Phase I/II clinical trials

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Proteins and Peptides: Strategies for Delivery to and Across the Skin

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Tocol emulsions for drug solubilization and parenteral delivery

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Polysialylated insulin: synthesis, characterization and biological activity in vivo

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Polymers for controlled parenteral delivery of peptides and proteins

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The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: implication in its pharmacokinetics

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Lipid Carriers: A Versatile Delivery Vehicle for Proteins and Peptides

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