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Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents
Abstract
Gold nanocages of <40 nm in dimension have been synthesized using the galvanic replacement reaction between Ag nanocubes and HAuCl4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800 nm, a wavelength commonly used in optical coherence tomography (OCT) imaging. OCT measurements on phantom samples indicate that these gold nanocages have a moderate scattering cross-section of approximately 8.10 x 10(-16) m2 but a very large absorption cross-section of approximately 7.26 x 10(-15) m2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells.
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Cited by
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Shape‐Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?
Xia, Y., Xiong, Y., Lim, B., & Skrabalak, S. E. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802248 · Cited by 5,702
Self-citationShape Control of Colloidal Metal Nanocrystals
Tao, A. R., Habas, S., & Yang, P. (2008) · Small · doi:10.1002/smll.200701295 · Cited by 2,408
Longmire, M., Choyke, P. L., & Kobayashi, H. (2008) · Nanomedicine · doi:10.2217/17435889.3.5.703 · Cited by 2,149
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,921
Metadata
- Authors
- Chen, J., Saeki, F., Wiley, B. J., Cang, H., Cobb, M. J., Li, Z.-Y., Au, L., Zhang, H., Kimmey, M. B., Li, X., & Xia, Y.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-02-08
- Volume
- 5
- Issue
- 3
- Pages
- 473-477
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2045723481
- Cited by
- 977
- References
- 0
- FWCI
- 28.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, J., Saeki, F., Wiley, B. J., Cang, H., Cobb, M. J., Li, Z.-Y., Au, L., Zhang, H., Kimmey, M. B., Li, X., & Xia, Y. (2005). Gold Nanocages: Bioconjugation and Their Potential Use as Optical Imaging Contrast Agents. Nano Letters. https://doi.org/10.1021/nl047950t
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