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Cited by 336

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Nanoscale Operation of a Living Cell Using an Atomic Force Microscope with a Nanoneedle

Obataya, Ikuo, Nakamura, Chikashi, Han, Nakamura, Noriyuki, Miyake, Jun·2005·Nano Letters
DOI 10.1021/nl0485399
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Abstract

We have developed a tool for performing surgical operations on living cells at nanoscale resolution using atomic force microscopy (AFM) and a modified AFM tip. The AFM tips are sharpened to ultrathin needles of 200-300 nm in diameter using focused ion beam etching. Force-distance curves obtained by AFM using the needles indicated that the needles penetrated the cell membrane following indentation to a depth of 1-2 microm. The force increase during the indentation process was found to be consistent with application of the Hertz model. A three-dimensional image generated by laser scanning confocal microscopy directly revealed that the needle penetrated both the cellular and nuclear membranes to reach the nucleus. This technique enables the extended application of AFM to analyses and surgery of living cells.

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Metadata

Authors
Obataya, I., Nakamura, C., Han, Nakamura, N., & Miyake, J.
Venue
Nano Letters
Publisher
American Chemical Society (ACS)
Published
2004-11-25
Volume
5
Issue
1
Pages
27-30
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
DOI
10.1021/nl0485399
OpenAlex
W2059413398
Cited by
336
References
0
FWCI
8.40
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Nanoscale Operation of a Living Cell Using an Atomic Force Microscope with a Nanoneedle. https://app.cochat.ai/papers/10.1021/nl0485399
The paper
Obataya, I., Nakamura, C., Han, Nakamura, N., & Miyake, J. (2005). Nanoscale Operation of a Living Cell Using an Atomic Force Microscope with a Nanoneedle. Nano Letters. https://doi.org/10.1021/nl0485399

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.